Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114991 - 114991
Published: July 4, 2023
Language: Английский
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Language: Английский
Citations
42
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215654 - 215654
Published: Jan. 20, 2024
Language: Английский
Citations
22
Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: 64(4), P. 397 - 438
Published: Oct. 1, 2024
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 10, 2024
Abstract Radiotherapy (RT) is one of the important treatment modalities for non-small cell lung cancer (NSCLC). However, maximum radiation dose that NSCLC patient can receive varies little. Therefore, exploitation novel RT sensitization approaches a critical need clinical treatment. resistance in linked to tumor microenvironment (TME) hypoxia, cycle arrest and associated genetic alterations. Here, we designed method targeted delivery quercetin (QT) CeO 2 enhance sensitivity. We loaded QT into @ZIF-8-HA nanoparticles prevent its degradation circulatory system successfully delivered tumors. Under protection Zeolitic Imidazolate Framework-8 (ZIF-8), nanocomplexes exhibited excellent catalytic mimetic activity decomposing H O , thus significantly reversing hypoxia TME, while radiosensitizer caused DNA damage directly after RT. In subcutaneous model, overcame enhanced therapeutic efficacy. This multiple strategy combining nanozymes opens promising approach NSCLC.
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161412 - 161412
Published: March 1, 2025
Language: Английский
Citations
1
Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 122 - 129
Published: Feb. 5, 2024
Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is characterized by high rate of recurrence, resulting in a poor survival. Standard treatments are associated with significant toxicities that impact the patient's quality life, highlighting urgent need for novel therapies to improve patient outcomes. On this regard, noble metal nanoparticles (NPs) emerging as promising agents both drug carriers radiosensitizers. other hand, co-treatments based on NPs still at preclinical stage because metal-persistence.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: June 1, 2024
In this paper, we introduce a theoretical framework for optical trapping that integrates nonlinear polarization within the dipole approximation. This theory represents most comprehensive analytic model to date capable of resolving discrepancies between observed and simulated plasmonic nanoparticles. Our elucidates how two-photon absorption can account stable gold nanoparticles, including their longitudinal stability, especially near plasmon resonance. Furthermore, experimentally split potential wells in transverse plane, which are attributed absorption, close agreement with our model's predictions. Finally, study provides new insights into mechanism under conditions intense light-matter interactions.
Language: Английский
Citations
3
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Abstract The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by as antigens, inducing an reaction dependent on patient's immunological anamnesis and from several factors including size, shape, chemical nature of nanoparticles. Furthermore, nanomaterials‐driven immunomodulation might exploited therapeutic purposes, opening new horizons in oncology beyond. In this scenario, we present a critical review state art regarding preclinical evaluation effects most promising metals biomedical applications (gold, silver, copper) system. Because exploiting interactions between inorganic may result game changer management (non)communicable diseases, within encounter need to summarize organize plethora sometimes inconsistent information, analyzing challenges providing expected perspectives. field is still its infancy, our work emphasizes deep understanding influence features metal both cultured cells animal models pivotal safe translation nanotherapeutics clinical practice.
Language: Английский
Citations
0
The European Physical Journal Plus, Journal Year: 2025, Volume and Issue: 140(4)
Published: April 28, 2025
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: June 7, 2025
Exosomes, as natural intercellular messengers, are gaining prominence delivery vehicles in nanomedicine, offering a superior alternative to conventional synthetic nanoparticles for cancer therapeutics. Unlike lipid, polymer, or metallic nanoparticles, which often face challenges related immunogenicity, targeting precision, and off-tumor toxicity, exosomes can effectively encapsulate diverse range of therapeutic agents while exhibiting low favorable pharmacokinetics, organotropic properties. This review examines recent advancements exosome bioengineering over the past decade. Innovations such microfluidics-based platforms, nanoporation, fusogenic hybrids, genetic engineering have significantly improved loading efficiencies, production scalability, pharmacokinetics exosomes. These facilitate tumor-specific cargo delivery, resulting substantial improvements retention efficacy essential clinical success. Moreover, enhanced biodistribution, targeting, bioavailability-through strategies cell selection, surface modifications, membrane composition alterations, biomaterial integration-suggests promising future an ideal nanomedicine platform. We also highlight translational impact these through emerging trials. Additionally, we outline framework translation that focuses on: sourcing, precision methodologies, route-specific optimization. In summary, this emphasizes potential overcome pharmacokinetic safety long impeded oncology drug development, thus enabling safer more effective treatments.
Language: Английский
Citations
0