International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125504 - 125504
Published: March 1, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114770 - 114770
Published: March 7, 2023
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.
Language: Английский
Citations
154
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 825 - 844
Published: Jan. 1, 2024
Abstract: Nanosuspensions have garnered recent attention as a promising strategy for mitigating the bioavailability challenges of hydrophobic drugs, particularly those characterized by poor solubility in both aqueous and organic environments. Addressing issues associated with poorly water-soluble drugs has largely resolved need to enhance drug absorption bioavailability. As mucosal formulations topical administration progress future, nanosuspension delivery, straightforward formulation techniques, versatile applications will continue be subjects interest. undergone extensive scrutiny preparation applications, encompassing ocular, pulmonary, dermal usage. Among numerous methods aimed at improving cutaneous application, nanocrystals represent relatively yet profoundly intriguing approach. Despite increasing availability various products, primarily designed oral administration, only limited number studies explored skin permeability accumulation context nanosuspensions. Nevertheless, scant published research unequivocally underscores potential this approach enhancing bioavailability, active ingredients low medium solubility. Nanocrystals exhibit increased adhesiveness addition heightened saturation dissolution rate, thereby augmenting distribution. The article provides comprehensive overview nanosuspensions application. methodology employed is robust, well-defined experimental design; however, sample size raises concerns about generalizability findings. While results demonstrate outcomes terms enhanced discussion falls short addressing certain limitations. Additionally, references focus on studies, but more diverse inclusion historical perspectives could offer holistic view subject. Keywords: nanosuspension, nanotechnology, topical,
Language: Английский
Citations
27
ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 11084 - 11102
Published: April 18, 2024
Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress–inflammation vicious cycle and complicated intercellular crosstalk within ocular microenvironment. Here, nanozyme-based drop, namely nanoceria loading cyclosporin A (Cs@P/CeO2), developed, which possesses long-term antioxidative anti-inflammatory capacities due to its regenerative activity sustained release (CsA). In vitro studies showed that dual-functional Cs@P/CeO2 not only inhibits cellular reactive oxygen species production, sequentially maintaining mitochondrial integrity, but also downregulates inflammatory processes repolarizes macrophages. Moreover, using flow cytometric single-cell sequencing data, in vivo therapeutic effect was systemically demonstrated, rebalances immune–epithelial communication corneal microenvironment less macrophage polarization, restrained stress, enhanced epithelium regeneration. Collectively, our data proved may provide insights into management.
Language: Английский
Citations
24
Science Advances, Journal Year: 2025, Volume and Issue: 11(10)
Published: March 7, 2025
Microneedles directly penetrating into the cornea inevitably cause pain, corneal structure damage, and reduced light transmittance. In this work, a minimally invasive annular microneedle (A-MN) patch was developed avoiding direct puncture central for ophthalmic drug delivery. The feasible mechanical strength of A-MNs achieved by adjusting ratio PVP-β-CD PVA to barrier. Through effective diffusion stroma, bioavailability hydrophilic small-molecule drugs, hydrophobic macromolecular protein drugs through an A-MN 24.36, 17.47, 5.36 times higher than that free administration. effectively maintained transmittance with 96.33 100%, which S-MNs. Furthermore, avoided tissue nerve damage along pain. efficiency safety were also examined both in vitro cell experiment vivo animal experimental model, showed great potential clinical application.
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 1 - 15
Published: Nov. 18, 2023
Language: Английский
Citations
24
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148576 - 148576
Published: Jan. 6, 2024
Language: Английский
Citations
17
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 8, 2024
Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing development of dry eye disease (DED). The currently available drops DED treatment are palliative, short-lived and frequently administered due to short precorneal residence time. Here, we developed nanozyme-based exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) poly(vinyl alcohol) (PVA) overcome these problems. resultant formulation (PBnZ), which has dual-ROS scavenging abilities prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect alleviate DED. In vitro in vivo experiments revealed that PBnZ could eliminate ROS through both its multienzyme-like activity ROS-scavenging borate bonds. positively charged displayed longer time physical adhesion bonds phenyboronic acid PVA or o-diol with mucin. results showed These dual-function provide insights into novel strategies other ROS-mediated inflammatory diseases rationale application nanomaterials clinical settings. Graphical
Language: Английский
Citations
17
Smart Molecules, Journal Year: 2024, Volume and Issue: 2(1)
Published: March 1, 2024
Abstract This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, classification hydrogels, explores synthesis responsive capabilities. Specific examined encompass topical drug delivery, contact lenses, intravitreal ocular adhesives, vitreous substitutes, cell‐based therapy. A methodical analysis, including an overview relevant structures comparative evaluation hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, research areas are identified. Our approach, guided by extensive literature from 2017 to 2023, illuminates unprecedented opportunities offered along pinpointing for further inquiry facilitate transition clinical practice.
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)
Published: Feb. 26, 2024
As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among diseases, fundus neovascularization diseases (FNDs) are prominent etiologies impairment worldwide. Intravitreal injection anti-vascular endothelial growth factor drugs remains primary therapy but is hurdled by common complications incomplete potency. To renovate current therapeutic modalities, nanomedicine emerged as times required, which endowed with advanced capabilities, able fulfill effective drug delivery achieve precise release control, thus further improving effect. This review provides a comprehensive summary advances in for FND management from state-of-the-art studies. First, modalities FNDs thoroughly introduced, focusing on key challenges delivery. Second, nanocarriers comprehensively reviewed posterior based nanostructures: polymer-based nanocarriers, lipid-based inorganic nanoparticles. Thirdly, characteristics microenvironment, their pathological changes during FNDs, corresponding strategies constructing smart elaborated. Furthermore, prospects discussed.
Language: Английский
Citations
11
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26616 - e26616
Published: Feb. 18, 2024
A multitude of sight-threatening retinal diseases, affecting hundreds millions around the globe, lack effective pharmacological treatments due to ocular barriers and common drug delivery limitations. Polymeric nanoparticles (PNPs) are versatile carriers with sustained release profiles tunable physicochemical properties which have been explored for both anterior posterior tissues. PNPs can incorporate a wide range drugs overcome challenges conventional delivery. Moreover, be engineered respond specific stimuli such as ultraviolet, visible, or near-infrared light, allow precise spatiotemporal control release, enabling tailored treatment regimens reducing number required administrations. The objective this study is emphasize therapeutic potential light-triggered drug-loaded polymeric treat diseases through an exploration pathologies, in delivery, current production methodologies recent applications. Despite challenges, light-responsive hold promise substantially enhancing landscape aiming improved quality life patients.
Language: Английский
Citations
10