Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 22, 2023

Abstract Ocular drug delivery has constantly challenged ophthalmologists and scientists due to various anatomical physiological barriers. Static dynamic ocular barriers prevent the entry of exogenous substances impede therapeutic agents' active absorption. This review elaborates on anatomy eye associated constraints. Followed by an illustration some common diseases, including glaucoma their current clinical therapies, emphasizing significance therapy in treating diseases. Subsequently, advances modalities, especially nanotechnology-based systems, are recommended, typical research is highlighted. Based related research, systematic comprehensive characterizations nanocarriers summarized, hoping assist with future research. Besides, we summarize ophthalmic drugs currently market or still trials recent patents nanocarriers. Finally, inspired trends concepts, provide insight into challenges faced novel systems further put forward directions for We hope this can inspiration motivation better design development formulations. Graphical abstract

Language: Английский

---

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15352 - 15352

Published: Oct. 19, 2023

Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.

Language: Английский

---

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.

Language: Английский

---

Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 8, 2024

Abstract Dry eye disease (DED) is associated with ocular hyperosmolarity and inflammation. The marketed topical drops for DED treatment often lack bioavailability precorneal residence time. In this study, we investigated catechol-functionalized polyzwitterion p(MPC- co -DMA), composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) dopamine methacrylamide (DMA) monomers, as potential nanotherapeutics DED. copolymers were synthesized via random free-radical copolymerization, producing different proportions catecholic functionalization. All as-prepared polymer compositions displayed good biocompatibility. At a feeding ratio 1:1, p(MPC 1 - -DMA ) can facilitate robust mucoadhesion Michael addition and/or Schiff base reaction, thus prolonging time after 4 days instillation. hydration lubrication MPC radical-scavenging DMA endow the nano-agent to ease tear-film corneal A single dose (1 mg/mL) post-instillation protect cornea against reactive oxygen species, inhibiting cell apoptosis over-expression pro-inflammatory factors (IL-6 TNF-α). clinical assessment, DED-induced rabbit eyes receiving could increase lacrimal fluid secretion by 5-fold higher than cyclosporine A. enhanced lubricity, mucoadhesion, anti-oxidation/anti-inflammation properties has shown high promise bioactive drop formulation treating

Language: Английский

---

Nanoceria-Mediated Cyclosporin A Delivery for Dry Eye Disease Management through Modulating Immune–Epithelial Crosstalk

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 11084 - 11102

Published: April 18, 2024

Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress–inflammation vicious cycle and complicated intercellular crosstalk within ocular microenvironment. Here, nanozyme-based drop, namely nanoceria loading cyclosporin A (Cs@P/CeO2), developed, which possesses long-term antioxidative anti-inflammatory capacities due to its regenerative activity sustained release (CsA). In vitro studies showed that dual-functional Cs@P/CeO2 not only inhibits cellular reactive oxygen species production, sequentially maintaining mitochondrial integrity, but also downregulates inflammatory processes repolarizes macrophages. Moreover, using flow cytometric single-cell sequencing data, in vivo therapeutic effect was systemically demonstrated, rebalances immune–epithelial communication corneal microenvironment less macrophage polarization, restrained stress, enhanced epithelium regeneration. Collectively, our data proved may provide insights into management.

Language: Английский

---

Recent progress of nanomedicine in managing dry eye disease

Advances in Ophthalmology Practice and Research, Journal Year: 2024, Volume and Issue: 4(1), P. 23 - 31

Published: Jan. 29, 2024

Dry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5 % to 50 %, impacting substantial proportion individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for diseases, it suffers drawbacks such as low bioavailability, rapid metabolism, and frequent requirements. Fortunately, advancements nanomedicine offer effective solutions address aforementioned issues provide assistance treatment DED. considered multifactorial surface tear film, which integrity film function structure plays crucial role maintaining homeostasis surface. conventional involves utilization artificial products, cyclosporin, corticosteroids, mucin secretagogues, nonsteroidal anti-inflammatory drugs. Furthermore, presently field study, numerous clinical trials underway various nanotherapeutics including nanoemulsions, nanosuspensions, liposomes, micelles. Notably, some these innovative nanoformulations have already received FDA approval novel remedies DED, advancement poised enhanced prospects solve shortcomings existing treatments partially. This article provides an overview latest treatment, while expected witness remarkable breakthrough shortly development nanomedicine, bringing promising patients suffering conditions.

Language: Английский

---

Engineered Mesenchymal Stromal Cell Exosomes-Loaded Microneedles Improve Corneal Healing after Chemical Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20065 - 20082

Published: July 24, 2024

Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to induce blindness. The main contributing mechanisms include excessive inflammation and delayed wound healing. Existing clinical therapies have limitations, promoting exploration of alternative methods that offer improved efficacy reduced side effects. Adipose-derived stem cell-exosome (ADSC-Exo) has sustain immune homeostasis facilitate tissue regeneration. Nevertheless, natural ADSC-Exo lacks disease specificity exhibits limited bioavailability on ocular surface. In this study, we conjugated antitumor necrosis factor-α antibodies (aT) surface using matrix metalloproteinase-cleavable peptide chains create engineered aT–Exo synergistic both in vivo vitro assessments, demonstrated superior mitigating corneal injuries compared aT alone, unmodified exosomes, or simply mixed exosomes. cleavable conjugation notably enhanced healing alleviated more effectively. Simultaneously, developed poly(vinyl alcohol) microneedles (MNs) for precise sustained exosome delivery. results showcased therapeutic efficiency MNs conventional topical administration subconjunctival injection. Therefore, bioactive nanodrugs-loaded treatment presents promising strategy addressing diseases.

Language: Английский

---

Drug in Drug: Quorum Sensing Inhibitor in Star-Shaped Antibacterial Polypeptides for Inhibiting and Eradicating Corneal Bacterial Biofilms

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops often compromised because bacteria biofilms resist bactericide

Language: Английский

---

Nanotechnology-based non-invasive strategies in ocular therapeutics: Approaches, limitations to clinical translation, and safety concerns

Contact Lens and Anterior Eye, Journal Year: 2025, Volume and Issue: unknown, P. 102367 - 102367

Published: Jan. 1, 2025

Language: Английский

---

Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 907 - 932

Published: Jan. 1, 2025

The main purpose of the study was formulation development nanogels (NHs) composed chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as potential treatment for early-stage diabetic retinopathy. Different formulations NHs were prepared by varying polymer concentration, lCH ratio, pH and, then, characterized particle size, zeta potential, concentration (particles/mL) morphology. Cytotoxicity internalization assessed in vitro using Human Umbilical Vein Endothelial Cells (HUVEC). NAR/β-CD evaluated morphology, complexation efficiency, solubility. Finally, most promising NH prototype (NH@NAR/β-CD) further encapsulation loading capacity, opacity cytotoxicity on HUVEC; release test DPPH assay performed to investigate capability sustain NAR NH@NAR/β-CD antioxidant properties, respectively. properties influenced pH. N3 (0.5 mg/mL; lCH=1.5:1; = 5) N9 lCH=1:1; showed optimal characteristics, including small size (<350 nm) positive facilitating cellular uptake. 71% efficiency enhanced Since superior better biocompatibility, NAR/β-CD. N3@NAR/β-CD release, radical scavenging activity biocompatibility finally demonstrated. physico-chemical responsible their cell uptake, suggesting target retinal endothelial cells. high sustained over 72 hours could guarantee maintenance an effective drug at damage site while reducing injection number. Further studies about safety effectiveness intravitreal NHs@NAR/β-CD will be animal model.

Language: Английский

---