Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(5), P. 100948 - 100948
Published: Sept. 7, 2024
As
the
third
essential
trace
element
in
human
body,
copper
plays
a
crucial
role
various
physiological
processes,
which
lays
foundation
for
its
broad
applications
cancer
treatments.
The
overview
of
copper,
including
pharmacokinetics,
signaling
pathways,
and
homeostasis
dysregulation,
is
hereby
discussed.
Additionally,
cuproptosis,
as
newly
proposed
cell
death
mechanism
associated
with
accumulation,
analyzed
further
developed
efficient
treatment.
Different
forms
Cu-based
nanoparticles
their
advantages,
well
limiting
factors,
are
introduced.
Moreover,
unique
characteristics
give
rise
to
imaging
modalities.
In
addition,
nanomaterials
featured
by
excellent
photothermal
property
ROS-associated
tumor-killing
potential,
widely
explored
diverse
therapies
combined
therapies.
Reducing
concentration
Cu
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
124(2), P. 554 - 628
Published: Nov. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(32)
Published: May 23, 2024
Clear
delineation
of
tumor
margins
is
essential
for
accurate
resection
and
decreased
recurrence
rate
in
the
clinic.
Fluorescence
imaging
emerging
as
a
promising
alternative
to
traditional
visual
inspection
by
surgeons
intraoperative
imaging.
However,
probes
lack
accuracy
diagnosis,
making
it
difficult
depict
boundaries
accurately.
Herein,
we
proposed
an
offensive
defensive
integration
(ODI)
strategy
based
on
"attack
systems
(invasive
peptidase)
defense
(reductive
microenvironment)"
multi-dimensional
characteristics
design
activatable
fluorescent
precisely.
Screened
out
from
series
ODI
strategy-based
probes,
ANQ
performed
better
than
unilateral
correlation
distinguishing
between
cells
normal
minimizing
false-positive
signals
living
metabolic
organs.
To
further
improve
signal-to-background
ratio
vivo,
derivatized
FANQ,
was
prepared
successfully
applied
distinguish
orthotopic
hepatocellular
carcinoma
tissues
adjacent
mice
models
clinical
samples.
This
work
highlights
innovative
develop
rapid
diagnosis
tumors
high-precision
boundaries,
providing
more
efficient
tools
future
applications
assisted
resection.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Jan. 18, 2024
Molecular
imaging
is
a
non-invasive
method
that
widely
used
for
visualization
and
detection
of
biological
events
at
cellular
or
molecular
levels.
Stimuli-responsive
linkers
can
be
selectively
cleaved
by
specific
biomarkers
desired
sites
to
release
activate
agents
are
appealing
tools
improve
the
specificity,
sensitivity,
efficacy
imaging.
This
review
summarizes
recent
advances
stimuli-responsive
their
application
in
imaging,
highlighting
potential
these
design
activatable
probes.
It
hoped
this
could
inspire
more
research
interests
development
responsive
associated
applications.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(48)
Published: Oct. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
