Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 206 - 206

Published: Jan. 10, 2024

Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, minimal side effects. Here, we present an overview with updated information on natural degradable where a brief account different polysaccharides, proteins, viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant has provided. The various approaches transformation of these by physical/chemical means cross-linking, as polyblends, nanocomposites/hybrid composites, interpenetrating complexes, interpolymer/polyion functionalization, polymer conjugates, block graft copolymers, are described. degradation mechanism, drug loading profiles, toxicological aspects polymeric nanoparticles formed also defined. Biomedical polymer-based biomaterials wound dressing/healing, biosensors, delivery systems, tissue engineering, regenerative medicine, etc., highlighted. In addition, use such nano systems solve current problems is briefly reviewed.

Language: Английский

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Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5145 - 5145

Published: June 30, 2023

Cancer continues to pose a severe threat global health, making pursuing effective treatments more critical than ever. Traditional therapies, although pivotal in managing cancer, encounter considerable challenges, including drug resistance, poor solubility, and difficulties targeting tumors, specifically limiting their overall efficacy. Nanomedicine's application cancer therapy signals new epoch, distinguished by the improvement of specificity, efficacy, tolerability treatments. This review explores mechanisms advantages nanoparticle-mediated delivery, highlighting passive active strategies. Furthermore, it transformative potential nanomedicine tumor therapeutics, delving into its applications across various treatment modalities, surgery, chemotherapy, immunotherapy, radiotherapy, photodynamic photothermal therapy, gene as well diagnosis imaging. Meanwhile, outlook therapeutics is discussed, emphasizing need for addressing toxicity concerns, improving delivery strategies, enhancing carrier stability controlled release, simplifying nano-design, exploring novel manufacturing technologies. Overall, integrating holds immense revolutionizing patient outcomes.

Language: Английский

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Controlling the biodistribution and clearance of nanomedicines

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(3), P. 214 - 232

Published: Dec. 20, 2023

Language: Английский

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Cancer signaling, cell/gene therapy, diagnosis and role of nanobiomaterials

Advances in Biology & Earth Sciences, Journal Year: 2024, Volume and Issue: 9(Special Issue), P. 11 - 34

Published: April 11, 2024

An important characteristic of cancer is aberrant metabolism. Drug resistance, stem cells, metastasis and tumorigenesis are all significantly impacted by abnormal metabolism, which includes enhanced anabolic pathways aerobic glycolysis. The Hippo pathway, Myc PI3K/AKT recognized oncogenic signaling networks that control the expression metabolic genes increase level activity enzymes. On other hand, result in disruptions to internal signal transduction providing energy, building blocks redox capabilities necessary for uncontrolled cell proliferation. Studies clinical trials being carried out investigate impact minute substances or dietary modifications, such as calorie restriction, fasting intermittent fasting, on inhibition phenotypes malignancies remarkably diverse, much like genetic variability. Genetic abnormalities a variety signals found tumor microenvironment contribute this Therefore, one main objectives contemporary therapies overcome plasticity. This overview explains relationships between biochemical emphasizes recent research properties cancer. We also present fresh justifications upcoming class medications target an our latest studies progress nanomedicine disease detection at tiny nano-bio interactions biological systems nanoparticles. Significant field has been accomplished last 20 years. However, absence thorough knowledge situation makes it difficult improve overall patient survival with nanomedicine.

Language: Английский

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Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2102 - 2102

Published: Aug. 9, 2023

Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene oxide) (PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to their low molecular weight polymer and greater number PEO segments, induce micelle formation gelation at critical concentrations temperatures. F-68 F-127 the only United States (U.S.) FDA-approved classes have been extensively used as materials for living bodies. fascinating characteristics Pluronics, many studies suggested role in biomedical applications, such drug delivery systems, tissue regeneration scaffolders, biosurfactants. As result, various performed using tool nanomedicine targeted systems. This review sought describe therapeutic cargos Pluronic F-127-based cancer nanomedicines composites combination therapy.

Language: Английский

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Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 25, 2023

Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate therapeutic effect. Surface modification these with target ligands can promote their cellular internalization, but modified may be subjected to unexpected recognition clearance. Herein, phenylboronic acid (PBA) group-shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)-inducing agent (epirubicin, Epi) indoleamine 2,3-dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for chemo-immunotherapy. This NLG919-loaded Epi-conjugated PEGylated dendrimers bridged boronate bonds (NLG919@Epi-DBP) maintains stable nanostructure during circulation. Under moderate acidic condition, PBA group exposes sialic residue on membrane enhance internalization penetration NLG919@Epi-DBP. At pH 5.0, NLG919@Epi-DBP rapidly disassembles release incorporated Epi NLG919. triggers robust ICD cells evokes strong response. In addition, inhibition IDO1 activity downregulates metabolism L-tryptophan kynurenine, leading reduction in recruitment modulation microenvironment. Collectively, this promising strategy has been demonstrated evoke as well remodel enhanced chemo-immunotherapeutic

Language: Английский

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Metal-based nanoparticle in cancer treatment: lessons learned and challenges

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 11, 2024

Cancer, being one of the deadliest diseases, poses significant challenges despite existence traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells effective treatment. In recent years, use metal nanoparticles (NPs) as promising alternative conventional therapies gained prominence in research. Metal NPs exhibit unique properties hold tremendous potential various applications Studies have demonstrated certain metals possess inherent or acquired anticancer capabilities through their surfaces. These make an attractive focus therapeutic development. this review, we will investigate applicability several distinct classes tumor targeting may include gold, silver, iron oxide, and other with can be exploited purposes. Additionally, provide comprehensive summary risk factors associated application NPs. Understanding addressing these crucial successful clinical translation mitigate any failures NP-based therapies. By exploring identifying factors, review aims contribute advancement strategies. The anticipated outcome is valuable insights pave way targeted utilizing patients.

Language: Английский

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Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 786 - 786

Published: Jan. 8, 2024

Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve therapy. Such play crucial role enhancing bioavailability substances, affecting therapy efficiency and precision. The targeted delivery drugs sites action minimization toxicity body is becoming possible through use these advanced carriers. Recent research has focused structures based biopolymers, including lipids, polysaccharides, proteins. This review paper description lipid-containing nanocomposite (including liposomes, lipid emulsions, nanoparticles, solid nanostructured carriers), polysaccharide-containing alginate cellulose), protein-containing (e.g., gelatin albumin). It was demonstrated many investigations that such show ability load therapeutic substances efficiently precisely control release. They also desirable biocompatibility, which promising sign for their potential application development indicates novel approach improving processes, contribute significant advances pharmacology, efficacy while minimizing side effects.

Language: Английский

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Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1076 - 1076

Published: Aug. 16, 2024

Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient unsafe delivery systems severe side effects, impeded the widespread use medicine. The purpose drug (DDSs) is to regulate time place release action. They aid enhancing equilibrium between medicinal efficacy on target hazardous effects off target. One promising approach biomaterial-assisted biotherapy, which takes advantage biomaterials’ special capabilities, high biocompatibility bioactive characteristics. When administered via different routes, molecules deal biological barriers; DDSs help them overcome these hurdles. With their adaptable features ample packing capacity, biomaterial-based allow for targeted, localised, prolonged medications. Additionally, they are being investigated more controlling interface host tissue implanted biomedical materials. This review discusses innovative nanoparticle designs non-personalised applications improve therapies. We prioritised design trends address heterogeneous barriers, because we believe intelligent can patient outcomes by enabling improving general efficacy. additionally reviewed most recent literature biomaterials used biotherapy vaccine development, covering delivery, stem cell therapy, gene other similar fields; also addressed difficulties future biotherapies.

Language: Английский

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Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9556 - 9556

Published: Sept. 3, 2024

Personal protective equipment (PPE) has attracted more attention since the outbreak of epidemic in 2019. Advanced nano techniques, such as electrospinning, can provide new routes for developing novel PPE. However, electrospun antibacterial PPE is not easily obtained. Fibers loaded with photosensitizers prepared using single-fluid electrospinning have a relatively low utilization rate due to influence embedding and their inadequate mechanical properties. For this study, monolithic nanofibers core–shell were compared. Monolithic F1 fibers comprising polyethylene oxide (PEO), poly(vinyl alcohol-co-ethylene) (PVA-co-PE), photo-antibacterial agent vitamin K3 (VK3) created blending process. Core–shell F2 coaxial which extensible material PEO was set core section, composite consisting PEO, PVA-co-PE, VK3 shell section. Both designed structural properties had an average diameter approximately 1.0 μm, determined scanning electron microscopy transmission microscopy. amorphously dispersed within polymeric matrices compatible manner, revealed X-ray diffraction Fourier transform infrared spectroscopy. higher tensile strength 2.917 ± 0.091 MPa, whereas longer elongation break 194.567 0.091%. Photoreaction tests showed that, adjustment, could produce 0.222 μmol/L ·OH upon illumination. slightly better performance than fibers, inhibition zones 1.361 0.012 cm 1.296 0.022 E. coli S. aureus, respectively, but less VK3. The intentional tailoring components compositions nanostructures improve process–structure–performance relationship potential sunlight-activated

Language: Английский

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