Neuronal guanine nucleotide exchange factor promotes the axonal growth and cancer cell proliferation via Ephrin-A3/EphA2 axis in lung adenocarcinoma DOI Creative Commons
Jie Mi, Wentian Zhang,

Yijiu Ren

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Neural infiltration has been found in various cancers and the infiltrating nerves influence tumor growth dissemination. In non-small cell lung cancer, pan-neuronal marker PGP9.5 was detected by immunohistochemical staining its high expression correlated with poor prognosis. However, existence of nerve fibers mechanism driving neural remains unclear. We first used to assess density patients adenocarcinoma different sizes. Following that, we performed differential analysis univariate Cox prognostic analysis, using public datasets experiments identify gene that triggers is associated cancer progression unfavorable Finally, molecular biology a subcutaneous model were deeply analyze regulates progression. patients, positive within tumors larger than 2 cm diameter significantly higher smaller cm. Bioinformatics suggested NGEF, KIF4A, PABPC1 could be genes trigger are Subsequent co-culture neurons showed increased NGEF cells enhanced axonal neurons. Meanwhile, GSE30219 indicated exhibiting levels sizes, lymph node involvement, reduced overall survival rates. At level mechanisms, knockdown Ephrin-A3 ND7/23 or use ALW-II-41-27 resulted significant decrease neurite outgrowth when co-cultured LA795 cells. animal model, overexpression promoted fibers, these effects inhibited ALW-II-41-27. facilitates through Ephrin-A3/EphA2 pathway, suggesting promising target for disrupting interactions between tumors. Biomaterials focus on anticipated potential treatment option cancer.

Language: Английский

Dendrimers for drug delivery: An overview of its classes, synthesis, and applications DOI
Rahul Sarode, Hitendra S. Mahajan

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105896 - 105896

Published: June 15, 2024

Language: Английский

Citations

17
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Coumarins as versatile therapeutic phytomolecules: A systematic review DOI
Mohd Kamil Hussain,

Shahnaaz Khatoon,

Mohammad Faheem Khan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155972 - 155972

Published: Aug. 30, 2024

Language: Английский

Citations

14
SILVER NANOPARTICLES FROM ASCORBIC ACID: BIOSYNTHESIS, CHARACTERIZATION, IN VITRO SAFETY PROFILE, ANTIMICROBIAL ACTIVITY AND PHYTOTOXICITY DOI
Lailla Daianna Soltau Missio Pinheiro,

GABRIELA GERALDO SANGOI,

Bruno Stefanello Vizzotto

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 325, P. 129715 - 129715

Published: July 14, 2024

Language: Английский

Citations

13
Ultrastructural investigation of iron oxide nanoparticles accumulation in the liver of common carp (Cyprinus carpio Linnaeus, 1758) DOI
Aysel Hajiyeva, Chingiz A. Mamedov, Eldar Gasımov

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 272, P. 106961 - 106961

Published: May 16, 2024

Language: Английский

Citations

12
CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer DOI Creative Commons
Yanna Li, Zhixiong Wang,

Peng Gao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 30, 2024

Circular RNAs (circRNAs) have been implicated in the development and progression of gastric cancer (GC). However, it remains unclear whether dysregulated circRNA affects immune escape efficacy immunotherapy GC. Our aim is to investigate molecular mechanism affecting GC identify effective therapeutic targets.

Language: Английский

Citations

11
Green-Synthesized Characterization, Antioxidant and Antibacterial Applications of CtAC/MNPs-Ag Nanocomposites DOI Creative Commons

Ayşe Baran,

Erdal Ertaş, Mehmet Fırat Baran

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 772 - 772

Published: June 13, 2024

The emergence of antibiotic resistance, caused by the improper use antibiotics, is a significant challenge in combating infectious diseases, leading to millions annual fatalities. occurrence antimicrobial side effects catalyzes investigation novel compounds and sources drugs. Consequently, research on biological activity that conducted plants, plant extracts, are produced from components utmost significance. In this study, CtAC/MNPs were obtained reaction activated carbon (AC) fruits Celtis tournefortii (Ct) magnetic nanoparticles (MNPs), CtAC/MNPs-Ag nanocomposite was synthesized reduction silver ions added reaction. nanocomposites analyzed spectroscopically (FTIR, XRD), microscopically (SEM, EDX), optically (DLS), electrochemically (zeta potential) magnetically (VSM). antibacterial activities against S. aureus E. coli investigated microdilution method using minimal inhibitory concentration (MIC) disk diffusion methods. Antioxidant including total phenolic content DPPH cuprac assays, revealed remarkable effect nanocomposite. This study has advantages obtaining short time without requiring energy, most importantly, takes place any toxic substances. addition, according data thought shed light biomedical research.

Language: Английский

Citations

10
Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway DOI Creative Commons

Sajad Fakhri,

Seyed Zachariah Moradi,

Seyed Yahya Moradi

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 2, 2024

Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy have significant adverse effects. Therefore, it is essential establish novel strategies for combating cancer. Phytochemicals, which possess multiple biological activities, such as antioxidant, anti-inflammatory, antimutagenic, immunomodulatory, antiproliferative, anti-angiogenesis, antimetastatic properties, can regulate interfere various stages of development by suppressing signaling pathways. The systematic comprehensive review was conducted based on Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) criteria, using electronic databases, including PubMed, Scopus, Science Direct, until end December 2023. After excluding unrelated articles, 111 related articles were included this review. In review, major pathways metabolism are highlighted with promising anticancer role phytochemicals. This through their ability AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) pathway. AMPK/PGC-1α pathway plays a crucial cell via targeting energy homeostasis mitochondria biogenesis, glucose oxidation, fatty acid thereby generating ATP growth. As result, may represent approach treatment. Accordingly, alkaloids, phenolic compounds, terpene/terpenoids, miscellaneous phytochemicals been introduced agents regulating Novel delivery systems also

Language: Английский

Citations

7
Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes DOI
Jiaqi Li,

Dezhi Chen,

Jialiang Suo

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 399, P. 111130 - 111130

Published: July 2, 2024

Language: Английский

Citations

6
Advancing cancer research through organoid technology DOI Creative Commons
Zeng Ge, Yifan Yu, Meiting Wang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 8, 2024

The complexity of tumors and the challenges associated with treatment often stem from limitations existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumor research. This bioengineering approach enables researchers to simulate, vitro, interactions between their microenvironment, thereby enhancing intricate interplay cells surroundings. Organoids also integrate multidimensional data, providing a novel paradigm understanding development progression while facilitating precision therapy. Furthermore, advancements imaging genetic editing techniques have significantly augmented potential organoids review explores application more precise simulations its specific contributions cancer research advancements. Additionally, we discuss evolving trends developing comprehensive utilizing technology.

Language: Английский

Citations

6