Long-acting microneedle formulations

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 201, P. 115055 - 115055

Published: Aug. 17, 2023

The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into dermal ocular space, but they can also control release profile active compound over a desired period. To enable prolonged delivery payloads, various MN types have been proposed evaluated, including dissolving MNs, polymeric loaded or coated nanoparticles, fast-separable hollow hydrogel MNs. These intricate yet intelligent platforms provide an attractive approach decrease side effects administration frequency, thus offer potential increase patient compliance. In this review, formulations that are for long-acting address clinical needs myriad diseases discussed. We highlight design aspects, such as polymer selection geometry, in addition computational mathematical modeling necessary help streamline develop high translational value impact. Finally, up-scale manufacturing regulatory hurdles along avenues require further research bring market carefully considered. It is hoped review will insight formulators clinicians judicious materials tandem refined may elegant achieve sustained payloads through simple patch.

Language: Английский

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The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116894 - 116894

Published: Aug. 14, 2023

Language: Английский

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Lyotropic liquid crystalline phases: Drug delivery and biomedical applications

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 647, P. 123546 - 123546

Published: Oct. 25, 2023

Language: Английский

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Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 256, P. 128488 - 128488

Published: Dec. 2, 2023

Language: Английский

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Amorphous Roxithromycin Loaded in-situ Gel for the Treatment of Staphylococcus aureus Induced Upper Respiratory Tract Infection

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 1471 - 1483

Published: March 1, 2025

Upper respiratory tract infections are among the most prevalent diseases, imposing both financial and physical burdens on affected individuals. Roxithromycin (ROX), a primary drug for treating bacterial-induced infections, is typically administered orally due to its hydrophobic nature. However, non-specific distribution resulting from oral administration reduces bioavailability can cause side effects such as diarrhea. In this study, we prepared thermo-sensitive in-situ gel using facile highly reproducible method by simply mixing two types of poloxamers with ROX. The ROX be well dissolved in poloxamer matrix amorphous state give solution. Upon intranasal administration, solution undergoes phase transition form under body temperature. This remains nasal cavity an extended period, releasing directly site infection minimizing distribution. Pharmacokinetic experiments revealed that, compared local increased 1.5 times, concentration 8 times. contrast, concentrations liver small intestine did not significantly differ those following administration. vivo antibacterial also showed that has superior efficacy excellent biocompatibility. These results suggest promising formulation bacterial upper infections.

Language: Английский

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Prostate cancer chemotherapy by intratumoral administration of Docetaxel-Mesoporous silica nanomedicines

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124623 - 124623

Published: Aug. 25, 2024

Docetaxel (DTX) is a recommended treatment in patients with metastasic prostate cancer (PCa), despite its therapeutic efficacy limited by strong systemic toxicity. However, localized PCa, intratumoral (IT) administration of DTX could be an alternative to consider that may help overcome the disadvantages conventional intravenous (IV) therapy. In this context, we here present first vivo preclinical study PCa therapy nanomedicines mesoporous silica nanoparticles (MSN) and IT injection over xenograft mouse model bearing human adenocarcinoma tumors. The tolerability, biodistribution histopathology after have been investigated for nanomedicine free drug, compared IV DTX. obtained results demonstrate allows precise selective non-metastatic minimize diffusion showing superior activity than route. This reducing dose one order widens substantially window drug. Furthermore, use as promotes antitumor drug accumulation at tumor site, improving same

Language: Английский

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Stimuli-Responsive Drug Delivery Systems for Inflammatory Skin Conditions

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 1 - 19

Published: Aug. 28, 2024

Inflammatory skin conditions highly influence the quality of life patients suffering from these disorders. Symptoms include red, itchy and painful lesions, which are visible to rest world, causing stigmatization a significantly lower mental health patients. Treatment options often unsatisfactory, as they suffer either low patient adherence or risk severe side effects. Considering this, there is need for new treatments, notably ways delivering drugs. Stimuli-responsive drug delivery systems able deliver their cargo in response given stimulus are, thus, promising treatment inflammatory conditions. For example, use external stimuli such ultraviolet light, near infrared radiation, alteration magnetic field enables release be precisely controlled space time. On other hand, internal induced by pathological condition, including pH upregulation reactive oxygen species enzymes, can utilized create that specifically target diseased achieve better efficacy safety. In latter context, however, it key importance match trigger mechanism system actual features specific condition. Hence, focus this article placed not only on reviewing stimuli-responsive developed treat conditions, but also critically evaluating context diseases. STATEMENT OF SIGNIFICANCE: Skin diseases affect one-third world's population, lowering patients, who deal with symptoms well due visibility symptoms. Current treatments hampered serious Therefore, more emphasis should developing innovative formulations provide safety hold considerable promise regard, where when needed, reducing adverse effects potentially offering outcomes.

Language: Английский

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QbD- Driven Development and Characterization of Lactoferrin-Loaded Nanoparticles in In-Situ Gel for Treating Postmenopausal Osteoporosis

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100142 - 100142

Published: Jan. 1, 2025

Language: Английский

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Bottlebrush Pastes as a Platform for Solvent-Free, Injectable, and Shape-Persistent Materials with Tissue-Mimetic Viscoelasticity

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Architecturally hindered crystallization of bottlebrush graft copolymers offers a reaction- and solvent-free pathway for creating injectable elastomers with tissue-mimetic softness. Currently, materials involve solvents chemical reactions, leading to uncontrolled swelling, leaching unreacted moieties, side reactions tissue. To address this issue, poly(ethylene glycol) (PEG) amorphous block crystallizable poly(lactic acid) (PLA) grafted chains (A-g-B) were synthesized, controlled length arranged along the backbone at spacing. The densely PEG brush is leveraged architecturally control both rate degree PLA grafts, offering tunability mechanical properties as function architecture time in single-component system covering broad range aggregation states comprising fluid-, paste-, elastomer-like behaviors modulus ranging from 1 50 kPa. PLA-g-PEG pastes are particularly interesting, they combine injectability time-controlled formation shape-persistent constant temperature. This molecular paste platform may advance reconstructive surgery, drug depots, tissue engineering.

Language: Английский

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Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 31, 2025

Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.

Language: Английский

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