Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 539 - 562
Published: Feb. 13, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
134
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)
Published: Feb. 14, 2024
Abstract Microfluidic chips play crucial roles while lack satisfactory controllability and comprehensive functionality. Inspired by biological systems, this study proposes a method utilizing rolling microneedles (RMNs) to generate muti‐structured templates, realizing photonic crystal membrane (PC) based meta microfluidic microneedle chip (MMM) for efficient wound management. This approach offers advantages in terms of speed cost‐effectiveness, achieving dual‐sided permeation patterned design directly RMNs at desired locations, serving as both template tools fabrication. The integration with PC results the 3D multilayer channels, effectively addressing issues related spontaneous fluid flow. As reaches membrane, it generates distinctive structural colors exhibits fluorescence enhancement, enabling monitoring inflammatory factors mouse wounds facilitating In summary, preparation involving paves way control chips. bioinspired patch holds significant potential not only management but also areas such clinical drug delivery point‐of‐care testing (POCT).
Language: Английский
Citations
24
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 210, P. 115326 - 115326
Published: April 30, 2024
Transdermal administration remains an active research and development area as alternative route for long-acting drug delivery. It avoids major drawbacks of conventional oral (gastrointestinal side effects, low bioavailability, multiple dosing) or parenteral routes (invasiveness, pain, psychological stress bio-hazardous waste generated from needles), thereby increasing patient appeal compliance. This review focuses on the current state transdermal delivery, including adhesive patches, microneedles, molecularly imprinted polymeric systems. Each subsection describes approach key considerations in formulation development, design, process parameters with schematics. An overview commercially available (adhesive) patches delivery (longer than 24 h), well advanced formulations such core-shell, nanoformulations-incorporated stimuli-responsive 3D-printed polymers is also provided. Finally, we elaborated translational aspects, challenges patch future directions clinical advancement new products
Language: Английский
Citations
17
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 43 - 66
Published: May 22, 2024
Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or single needle. These MNs offer a minimally invasive approach to ocular drug delivery due their micron size (reducing tissue damage compared that of hypodermic needles) and overcoming significant barriers administration. While various types have been extensively researched, progress has made the use hollow (HMNs) for delivery, specifically through suprachoroidal injections. The space, situated between sclera choroid, targeted using optical coherence tomography-guided injections HMNs treatment uveitis. Unlike other MNs, can deliver larger volumes formulations eye. This review primarily focuses on explores anatomy distribution following potential HMN administration routes. Additionally, this influence formulation characteristics (e.g., solution viscosity, particle size), properties bore lumen diameter, MN length), routes periocular transscleral, suprachoroidal, intravitreal) drugs. Overall, paper highlights distinctive HMNs, which make them promising technology improving efficiency, precision, patient outcomes diseases.
Language: Английский
Citations
16
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Abstract High‐tension site wounds are frequently accompanied by challenges associated with hypertrophic scarring. The key to achieving scar‐free healing is the creation of a mechanical environment conducive skin regeneration. Herein, simple rolling punctures utilized on angle transform molds develop cat tongue prick bionic angle‐adjustable microneedles (TPMNs) maintain firm grip periwound skin, thereby reducing tissue tension. integration TPMNs triboelectric nanogenerators (TENGs) enables excellent conductive and properties. system can provide stable spatial electric field around wound promote cell migration. As microfluid reaches TPMNs, self‐driving force enhanced unique design control flow rate. Sufficient evidence has shown that expedite contraction regeneration while concurrently scar formation in mouse trauma model experiments. innovative TPMNs‐TENGs synergistically provides highly functional platform for tension relief, which suitable treatment this study potentially extends construction regulation smart wearable devices.
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 786 - 796
Published: Jan. 25, 2025
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124071 - 124071
Published: March 29, 2024
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used these to mimic human skin conditions accurately. However, when focusing on protein and peptide transdermal delivery, utilising biological can complicate analysis quantification processes. This study aims explore Parafilm®M Strat-M® as alternatives dermatomed porcine for evaluating delivery from dissolving microarray patch (MAP) platforms. Initially, various MAPs loaded with different proteins (ovalbumin, bovine serum albumin amniotic mesenchymal stem cell metabolite products) were prepared. These underwent evaluation insertion properties profiles combined membranes, skin, Parafilm®M, Strat-M®. Insertion indicated that both showed comparable depths (in range of 360-430 µm), suggesting promise membrane substitutes studies. studies, synthetic such demonstrated the ability bypass protein-derived interference, providing more reliable results compared neonatal skin. Consequently, findings present valuable tools preliminary screening across MAP formulations, especially peptides.
Language: Английский
Citations
15
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
15
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 237 - 237
Published: Feb. 6, 2024
Microneedle (MN) technology is an optimal choice for the delivery of drugs via transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine and disease diagnostics. The biomedical device that offers many advantages including but not limited to painless experience, being time-effective, real-time sensing. This research implements additive manufacturing (AM) fabricate arrays advanced therapeutic applications. Stereolithography (SLA) was used six designs three aspect ratios. array included conical-shaped 100 needles (10 × 10 needle) in each array. microneedles were characterized using optical scanning electron microscopy evaluate dimensional accuracy. Further, mechanical insertion tests performed analyze strength skin penetration capabilities polymeric MN. MNs higher ratios had deformation characteristics suitable deeper levels beyond stratum corneum. both 0.3 mm 0.4 base diameters displayed consistent force–displacement behavior during skin-equivalent test. establishes guidelines fabricating high-accuracy low-cost 3D printing.
Language: Английский
Citations
14
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 161, P. 213889 - 213889
Published: May 9, 2024
Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly prescribed for managing osteoarthritis, rheumatoid arthritis, and post-surgical pain. However, oral administration of diclofenac often leads to adverse effects. This study introduces an innovative nano-in-micro approach create nanoparticle-loaded microneedle patches aimed at localised, sustained pain relief, circumventing the drawbacks delivery. The nanoparticles were produced via wet-milling, achieving average size 200 nm, then incorporated into patches. These showed improved skin penetration in ex vivo tests using Franz-cell setups compared traditional formulations. In on rats revealed that allowed quick drug uptake prolonged release, maintaining levels tissues up 72 h. With systemic bioavailability 57 %, these prove be effective means transdermal highlights potential this novel delivery system enhancing treatment chronic with reduced side
Language: Английский
Citations
13