International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15352 - 15352
Published: Oct. 19, 2023
Ocular
diseases
profoundly
impact
patients’
vision
and
overall
quality
of
life
globally.
However,
effective
ocular
drug
delivery
presents
formidable
challenges
within
clinical
pharmacology
biomaterial
science,
primarily
due
to
the
intricate
anatomical
physiological
barriers
unique
eye.
In
this
comprehensive
review,
we
aim
shed
light
on
features
eye,
emphasizing
natural
it
administration.
Our
goal
is
provide
a
thorough
overview
various
characteristics
inherent
each
nano-based
system.
These
encompass
nanomicelles,
nanoparticles,
nanosuspensions,
nanoemulsions,
microemulsions,
nanofibers,
dendrimers,
liposomes,
niosomes,
nanowafers,
contact
lenses,
hydrogels,
microneedles,
innovative
gene
therapy
approaches
employing
techniques.
We
delve
into
biology
methodology
these
systems,
introducing
their
applications
over
past
decade.
Furthermore,
discuss
advantages
illuminated
by
recent
studies.
While
systems
for
ophthalmic
formulations
are
gaining
increasing
attention,
further
research
imperative
address
potential
safety
toxicity
concerns.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Novel
biomaterials
are
becoming
more
crucial
in
treating
human
diseases.
However,
many
materials
require
complex
artificial
modifications
and
synthesis,
leading
to
potential
difficulties
preparation,
side
effects,
clinical
translation.
Recently,
significant
progress
has
been
achieved
terms
of
direct
self-assembly
natural
products
from
herbal
medicine
(NPHM),
an
important
source
for
novel
medications,
resulting
a
wide
range
bioactive
supramolecular
including
gels,
nanoparticles.
The
NPHM-based
produced
renewable
resources,
simple
prepare,
have
demonstrated
multi-functionality
slow-release,
smart-responsive
release,
especially
possess
powerful
biological
effects
treat
various
In
this
review,
revealed
as
emerging,
revolutionary,
promising
strategy.
development,
advantages,
limitations
NPHM,
well
the
advantageous
position
materials,
first
reviewed.
Subsequently,
systematic
comprehensive
analysis
strategies
specific
seven
major
classes
NPHM
is
highlighted.
Insights
into
influence
structural
features
on
formation
also
provided.
Finally,
drivers
preparations
summarized,
emphasizing
biomedical
applications,
future
scientific
challenges,
opportunities,
with
hope
igniting
inspiration
research
applications.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
371, P. 43 - 66
Published: May 22, 2024
Microneedles
(MNs)
are
micron-sized
needles,
typically
<2
mm
in
length,
arranged
either
as
an
array
or
single
needle.
These
MNs
offer
a
minimally
invasive
approach
to
ocular
drug
delivery
due
their
micron
size
(reducing
tissue
damage
compared
that
of
hypodermic
needles)
and
overcoming
significant
barriers
administration.
While
various
types
have
been
extensively
researched,
progress
has
made
the
use
hollow
(HMNs)
for
delivery,
specifically
through
suprachoroidal
injections.
The
space,
situated
between
sclera
choroid,
targeted
using
optical
coherence
tomography-guided
injections
HMNs
treatment
uveitis.
Unlike
other
MNs,
can
deliver
larger
volumes
formulations
eye.
This
review
primarily
focuses
on
explores
anatomy
distribution
following
potential
HMN
administration
routes.
Additionally,
this
influence
formulation
characteristics
(e.g.,
solution
viscosity,
particle
size),
properties
bore
lumen
diameter,
MN
length),
routes
periocular
transscleral,
suprachoroidal,
intravitreal)
drugs.
Overall,
paper
highlights
distinctive
HMNs,
which
make
them
promising
technology
improving
efficiency,
precision,
patient
outcomes
diseases.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
High‐tension
site
wounds
are
frequently
accompanied
by
challenges
associated
with
hypertrophic
scarring.
The
key
to
achieving
scar‐free
healing
is
the
creation
of
a
mechanical
environment
conducive
skin
regeneration.
Herein,
simple
rolling
punctures
utilized
on
angle
transform
molds
develop
cat
tongue
prick
bionic
angle‐adjustable
microneedles
(TPMNs)
maintain
firm
grip
periwound
skin,
thereby
reducing
tissue
tension.
integration
TPMNs
triboelectric
nanogenerators
(TENGs)
enables
excellent
conductive
and
properties.
system
can
provide
stable
spatial
electric
field
around
wound
promote
cell
migration.
As
microfluid
reaches
TPMNs,
self‐driving
force
enhanced
unique
design
control
flow
rate.
Sufficient
evidence
has
shown
that
expedite
contraction
regeneration
while
concurrently
scar
formation
in
mouse
trauma
model
experiments.
innovative
TPMNs‐TENGs
synergistically
provides
highly
functional
platform
for
tension
relief,
which
suitable
treatment
this
study
potentially
extends
construction
regulation
smart
wearable
devices.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(10)
Published: March 7, 2025
Microneedles
directly
penetrating
into
the
cornea
inevitably
cause
pain,
corneal
structure
damage,
and
reduced
light
transmittance.
In
this
work,
a
minimally
invasive
annular
microneedle
(A-MN)
patch
was
developed
avoiding
direct
puncture
central
for
ophthalmic
drug
delivery.
The
feasible
mechanical
strength
of
A-MNs
achieved
by
adjusting
ratio
PVP-β-CD
PVA
to
barrier.
Through
effective
diffusion
stroma,
bioavailability
hydrophilic
small-molecule
drugs,
hydrophobic
macromolecular
protein
drugs
through
an
A-MN
24.36,
17.47,
5.36
times
higher
than
that
free
administration.
effectively
maintained
transmittance
with
96.33
100%,
which
S-MNs.
Furthermore,
avoided
tissue
nerve
damage
along
pain.
efficiency
safety
were
also
examined
both
in
vitro
cell
experiment
vivo
animal
experimental
model,
showed
great
potential
clinical
application.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
658, P. 124195 - 124195
Published: May 3, 2024
Microneedles
(MN)
have
emerged
as
an
innovative
technology
for
drug
delivery,
offering
a
minimally
invasive
approach
to
administer
therapeutic
agents.
Recent
applications
included
ocular
requiring
the
manufacture
of
sub-millimeter
needle
arrays
in
reproducible
and
reliable
manner.
The
development
3D
printing
technologies
has
facilitated
fabrication
MN
via
mold
production,
although
there
is
paucity
information
available
regarding
how
parameters
may
influence
crucial
issues
such
sharpness
penetration
efficacy.
In
this
study,
we
developed
optimized
3D-printed
micro-mold
using
stereolithography
(SLA)
prepare
dissolving
patch.
effects
range
including
aspect
ratio,
layer
thickness,
length,
shape
orientation
been
examined
with
regard
both
architecture
accuracy
micro-mold,
while
angle
on
fidelity
was
also
basic
shapes
(conical,
pyramidal
triangular
pyramidal).
Mechanical
strength
vitro
polymeric
(PVP/PVA)
patch
produced
from
reverse
molds
fabricated
height,
ratios
were
assessed,
followed
by
ex
vivo
studies
into
excised
scleral
corneal
tissues.
optimization
process
identified
required
produce
sharpest
tips
highest
dimensional
fidelity,
indicated
that
these
systems
would
penetrate
tissue
minimal
applied
pressure,
thereby
allowing
ease
patient
self-administration.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 237 - 237
Published: Feb. 6, 2024
Microneedle
(MN)
technology
is
an
optimal
choice
for
the
delivery
of
drugs
via
transdermal
route,
with
a
minimally
invasive
procedure.
MN
applications
are
varied
from
drug
delivery,
cosmetics,
tissue
engineering,
vaccine
and
disease
diagnostics.
The
biomedical
device
that
offers
many
advantages
including
but
not
limited
to
painless
experience,
being
time-effective,
real-time
sensing.
This
research
implements
additive
manufacturing
(AM)
fabricate
arrays
advanced
therapeutic
applications.
Stereolithography
(SLA)
was
used
six
designs
three
aspect
ratios.
array
included
conical-shaped
100
needles
(10
×
10
needle)
in
each
array.
microneedles
were
characterized
using
optical
scanning
electron
microscopy
evaluate
dimensional
accuracy.
Further,
mechanical
insertion
tests
performed
analyze
strength
skin
penetration
capabilities
polymeric
MN.
MNs
higher
ratios
had
deformation
characteristics
suitable
deeper
levels
beyond
stratum
corneum.
both
0.3
mm
0.4
base
diameters
displayed
consistent
force–displacement
behavior
during
skin-equivalent
test.
establishes
guidelines
fabricating
high-accuracy
low-cost
3D
printing.
