Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery DOI Creative Commons
Satish Rojekar,

Swapnali Parit,

Amol D. Gholap

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1398 - 1398

Опубликована: Окт. 30, 2024

Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating diseases. This review explores its potential impact, recent advancements, and clinical uses. minimally invasive technique offers precise control of to the eye, with various microneedle types showing penetrate barriers cornea sclera, ensuring effective delivery. Recent advancements have improved safety efficacy, offering sustained controlled for conditions like age-related macular degeneration glaucoma. While promising, such as regulatory long-term biocompatibility persist. Overcoming these through interdisciplinary research is crucial. Ultimately, presents a revolutionary method significantly enhance disease treatment, marking new era eye care.

Язык: Английский

Strategies to develop polymeric microneedles for controlled drug release DOI
Bo Zhi Chen,

Yu Ting He,

Ze Qiang Zhao

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115109 - 115109

Опубликована: Окт. 30, 2023

Язык: Английский

Процитировано

58

Overview of Recent Advances in Nano-Based Ocular Drug Delivery DOI Open Access

L Liu,

Yi‐Hao Chen, Da‐Wen Lu

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15352 - 15352

Опубликована: Окт. 19, 2023

Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.

Язык: Английский

Процитировано

53

Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials DOI Creative Commons
Xiaohang Guo, Weikang Luo,

Lingyu Wu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

Процитировано

44

Hollow microneedles for ocular drug delivery DOI Creative Commons

Shilpkala Gade,

Katie Glover, Deepakkumar Mishra

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 43 - 66

Опубликована: Май 22, 2024

Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or single needle. These MNs offer a minimally invasive approach to ocular drug delivery due their micron size (reducing tissue damage compared that of hypodermic needles) and overcoming significant barriers administration. While various types have been extensively researched, progress has made the use hollow (HMNs) for delivery, specifically through suprachoroidal injections. The space, situated between sclera choroid, targeted using optical coherence tomography-guided injections HMNs treatment uveitis. Unlike other MNs, can deliver larger volumes formulations eye. This review primarily focuses on explores anatomy distribution following potential HMN administration routes. Additionally, this influence formulation characteristics (e.g., solution viscosity, particle size), properties bore lumen diameter, MN length), routes periocular transscleral, suprachoroidal, intravitreal) drugs. Overall, paper highlights distinctive HMNs, which make them promising technology improving efficiency, precision, patient outcomes diseases.

Язык: Английский

Процитировано

22

Recent advances in microneedles for drug delivery and theranostic application DOI
Mayuri Gupta,

Nimisha Srivastava,

Anil Rai

и другие.

European Polymer Journal, Год журнала: 2025, Номер 228, С. 113773 - 113773

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

4

Tongue Prick Bionic Angularly Adjustable Microneedles for Enhanced Scarless Wound Healing DOI Open Access

Ni Gan,

Xin Li,

Meng Wei

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract High‐tension site wounds are frequently accompanied by challenges associated with hypertrophic scarring. The key to achieving scar‐free healing is the creation of a mechanical environment conducive skin regeneration. Herein, simple rolling punctures utilized on angle transform molds develop cat tongue prick bionic angle‐adjustable microneedles (TPMNs) maintain firm grip periwound skin, thereby reducing tissue tension. integration TPMNs triboelectric nanogenerators (TENGs) enables excellent conductive and properties. system can provide stable spatial electric field around wound promote cell migration. As microfluid reaches TPMNs, self‐driving force enhanced unique design control flow rate. Sufficient evidence has shown that expedite contraction regeneration while concurrently scar formation in mouse trauma model experiments. innovative TPMNs‐TENGs synergistically provides highly functional platform for tension relief, which suitable treatment this study potentially extends construction regulation smart wearable devices.

Язык: Английский

Процитировано

3

Optimization of stereolithography 3D printing of microneedle micro-molds for ocular drug delivery DOI Creative Commons
Rawan Fitaihi, Shorooq Abukhamees,

Se Hun Chung

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124195 - 124195

Опубликована: Май 3, 2024

Microneedles (MN) have emerged as an innovative technology for drug delivery, offering a minimally invasive approach to administer therapeutic agents. Recent applications included ocular requiring the manufacture of sub-millimeter needle arrays in reproducible and reliable manner. The development 3D printing technologies has facilitated fabrication MN via mold production, although there is paucity information available regarding how parameters may influence crucial issues such sharpness penetration efficacy. In this study, we developed optimized 3D-printed micro-mold using stereolithography (SLA) prepare dissolving patch. effects range including aspect ratio, layer thickness, length, shape orientation been examined with regard both architecture accuracy micro-mold, while angle on fidelity was also basic shapes (conical, pyramidal triangular pyramidal). Mechanical strength vitro polymeric (PVP/PVA) patch produced from reverse molds fabricated height, ratios were assessed, followed by ex vivo studies into excised scleral corneal tissues. optimization process identified required produce sharpest tips highest dimensional fidelity, indicated that these systems would penetrate tissue minimal applied pressure, thereby allowing ease patient self-administration.

Язык: Английский

Процитировано

16

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications DOI Creative Commons
Faisal Khaled Aldawood, Santosh Kumar Parupelli, Abhay Andar

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 237 - 237

Опубликована: Фев. 6, 2024

Microneedle (MN) technology is an optimal choice for the delivery of drugs via transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine and disease diagnostics. The biomedical device that offers many advantages including but not limited to painless experience, being time-effective, real-time sensing. This research implements additive manufacturing (AM) fabricate arrays advanced therapeutic applications. Stereolithography (SLA) was used six designs three aspect ratios. array included conical-shaped 100 needles (10 × 10 needle) in each array. microneedles were characterized using optical scanning electron microscopy evaluate dimensional accuracy. Further, mechanical insertion tests performed analyze strength skin penetration capabilities polymeric MN. MNs higher ratios had deformation characteristics suitable deeper levels beyond stratum corneum. both 0.3 mm 0.4 base diameters displayed consistent force–displacement behavior during skin-equivalent test. establishes guidelines fabricating high-accuracy low-cost 3D printing.

Язык: Английский

Процитировано

15

Block copolymer micelles as ocular drug delivery systems DOI Creative Commons
Ahmad A. Assiri, Katie Glover, Deepakkumar Mishra

и другие.

Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104098 - 104098

Опубликована: Июль 10, 2024

Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier preparation, sterilization, superior solubilization, compared with other nanocarriers. Preclinical studies have shown promising results, advancing them toward clinical trials. Their mucoadhesive properties enhance prolong contact ocular surface, their small size allows deeper penetration through tissues, cornea. Additionally, copolymeric improve stability hydrophobic drugs, sustain release, allow for surface modifications to biocompatibility. Despite these benefits, long-term remains challenge. In this review, we highlight preclinical performance, structural frameworks, preparation techniques, physicochemical properties, current developments, prospects block delivery systems.

Язык: Английский

Процитировано

12

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases DOI Creative Commons

Qingdong Bao,

Xiaoting Zhang,

Zhankun Hao

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 13, 2024

Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.

Язык: Английский

Процитировано

11