Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 16, 2024
Abstract
Stem
cell‐related
therapeutic
technologies
have
garnered
significant
attention
of
the
research
community
for
their
multi‐faceted
applications.
To
promote
effects
stem
cells,
strategies
cell
microencapsulation
in
hydrogel
microparticles
been
widely
explored,
as
potential
to
facilitate
oxygen
diffusion
and
nutrient
transport
alongside
ability
crucial
cell‐cell
cell‐matrix
interactions.
Despite
promise,
there
is
an
acute
shortage
automated,
standardized,
reproducible
platforms
further
research.
Microfluidics
offers
intriguing
platform
produce
cell‐laden
(SCHMs)
owing
its
manipulate
fluids
at
micrometer
scale
well
precisely
control
structure
composition
microparticles.
In
this
review,
typical
biomaterials
crosslinking
methods
microfluidic
encapsulation
cells
progress
droplet‐based
microfluidics
fabrication
SCHMs
are
outlined.
Moreover,
important
biomedical
applications
highlighted,
including
regenerative
medicine,
tissue
engineering,
scale‐up
production
microenvironmental
simulation
fundamental
studies.
Overall,
holds
tremendous
enabling
diverse
worthy
various
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 9, 2025
Cardiac
fibrosis
plays
a
critical
role
in
the
progression
of
various
forms
heart
disease,
significantly
increasing
risk
sudden
cardiac
death.
However,
currently,
there
are
no
therapeutic
strategies
available
to
prevent
onset
fibrosis.
Here,
biomimetic
ATP-responsive
nanozymes
based
on
genetically
engineered
cell
membranes
adapted
specifically
recognize
activated
fibroblasts
(CFs)
for
treatment
By
fusing
anti-FAP
CAR
membrane
zeolitic
imidazole
frameworks-90
(zif-90)
cores
loaded
with
antioxidant
CeO2
and
siCTGF
(siRNA
targeting
CTGF),
these
nanoparticles,
called
FM@zif-90/Ce/siR
NPs,
demonstrated
effectively
reduce
accumulation
myofibroblasts
formation
fibrotic
tissue,
while
restoring
function.
These
findings
demonstrate
that
combination
has
beneficial
curative
effect
fibrosis,
significant
translational
potential.
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: July 11, 2024
Abstract
Bacteria
extracellular
vesicles
(BEVs),
characterized
as
the
lipid
bilayer
membrane-surrounded
nanoparticles
filled
with
molecular
cargo
from
parent
cells,
play
fundamental
roles
in
bacteria
growth
and
pathogenesis,
well
facilitating
essential
interaction
between
host
systems.
Notably,
benefiting
their
unique
biological
functions,
BEVs
hold
great
promise
novel
nanopharmaceuticals
for
diverse
biomedical
potential,
attracting
significant
interest
both
industry
academia.
Typically,
are
evaluated
promising
drug
delivery
platforms,
on
account
of
intrinsic
cell-targeting
capability,
ease
versatile
engineering,
capability
to
penetrate
physiological
barriers.
Moreover,
attributing
considerable
immunogenicity,
able
interact
immune
system
boost
immunotherapy
nanovaccine
against
a
wide
range
diseases.
Towards
these
directions,
this
review,
we
elucidate
nature
role
activating
response
better
understanding
BEV-based
nanopharmaceuticals’
development.
Additionally,
also
systematically
summarize
recent
advances
achieving
target
genetic
material,
therapeutic
agents,
functional
materials.
Furthermore,
vaccination
strategies
using
carefully
covered,
illustrating
flexible
potential
combating
bacterial
infections,
viral
cancer.
Finally,
current
hurdles
further
outlook
will
be
provided.
Graphical
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
