Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 8, 2024
Abstract
Thrombotic
cardiovascular
diseases
are
a
prevalent
factor
contributing
to
both
physical
impairment
and
mortality.
Thrombolysis
ischemic
mitigation
have
emerged
as
leading
contemporary
therapeutic
approaches
for
addressing
the
consequences
of
injury
reperfusion
damage.
Herein,
an
innovative
cellular-cloaked
spermatozoon-driven
microcellular
submarine
(SPCS),
comprised
multimodal
motifs,
was
designed
integrate
nano-assembly
thrombolytics
with
immunomodulatory
ability
derived
from
innate
magnetic
hyperthermia.
Rheotaxis-based
navigation
utilized
home
cross
clot
barrier,
finally
accumulate
in
vascular
organs,
where
thrombolytic
motif
“switched-on”
by
action
thrombus
red
blood
cell-driven
In
murine
model,
SPCS
system
combining
hyperthermia
demonstrated
capacity
augment
delivery
efficacy,
produce
nanotherapeutic
outcomes,
exhibit
potent
activity,
ameliorate
tissue
These
findings
underscore
multifaceted
potential
our
approach,
offering
ischemia-mitigating
effects.
Given
its
extended
effects
thrombus-targeting
capability,
this
biocompatible
holds
promise
agent
enhancing
efficacy
preventing
risks
after
managing
thrombosis.
Graphical
abstract
Journal of Materials Chemistry C,
Journal Year:
2024,
Volume and Issue:
12(27), P. 9868 - 9887
Published: Jan. 1, 2024
As
emerging
medical
tool
microneedles
have
attracted
significant
attention
since
puncture
the
skin
noninvasively
and
painlessly,
facilitating
tasks
such
as
physiological
monitoring,
disease
diagnosis,
transdermal
drug
delivery.
Science Robotics,
Journal Year:
2024,
Volume and Issue:
9(97)
Published: Dec. 11, 2024
Micro-
and
nanorobots
excel
in
navigating
the
intricate
often
inaccessible
areas
of
human
body,
offering
immense
potential
for
applications
such
as
disease
diagnosis,
precision
drug
delivery,
detoxification,
minimally
invasive
surgery.
Despite
their
promise,
practical
deployment
faces
hurdles,
including
achieving
stable
propulsion
complex
vivo
biological
environments,
real-time
imaging
localization
through
deep
tissue,
precise
remote
control
targeted
therapy
ensuring
high
therapeutic
efficacy.
To
overcome
these
obstacles,
we
introduce
a
hydrogel-based,
imaging-guided,
bioresorbable
acoustic
microrobot
(BAM)
designed
to
navigate
body
with
stability.
Constructed
using
two-photon
polymerization,
BAM
comprises
magnetic
nanoparticles
agents
integrated
into
its
hydrogel
matrix
delivery.
The
features
an
optimized
surface
chemistry
hydrophobic
inner
layer
substantially
enhance
microbubble
retention
biofluids
multiday
functionality
hydrophilic
outer
minimize
aggregation
promote
timely
degradation.
dual-opening
bubble-trapping
cavity
design
enables
maintain
consistent
efficient
across
range
fluids.
Under
focused
ultrasound
stimulation,
entrapped
microbubbles
oscillate
contrast
imaging,
facilitating
tracking
movement
wireless
navigation.
Moreover,
hydrolysis-driven
biodegradability
BAMs
ensures
safe
dissolution
after
treatment,
posing
no
risk
long-term
residual
harm.
Thorough
vitro
experimental
evidence
demonstrates
promising
capabilities
biomedical
applications.
This
approach
shows
promise
advancing
medical
interventions
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
Gas-filled
microbubbles
have
been
extensively
used
as
contrast
agents
for
ultrasound
therapies
and
recently
explored
microrobots.
When
exposed
to
an
intense
acoustic
wave,
oscillate
scatter
the
sound
field,
leading
assembly
manipulation
behaviors.
Although
traditional
demonstrated
promising
potential
in
physiological
environments,
we
recognized
need
improved
selectivity
acoustically
directed
propulsion.
For
this,
developed
a
new
microbubble
design
using
microfluidics.
We
engineered
with
outer
oil
droplet
encapsulating
gas
core,
allowing
move
freely
within
oil.
reaches
droplet’s
periphery,
attenuates
scattered
ensuring
that
scattering
or
amplification
is
concentrated
near
edge.
This
approach
enabled
us
control
organized
of
direct
their
navigation.
believe
this
will
open
possibilities
gas-filled
safer
drug
carriers
micro-interventions
biomedical
settings.
Advanced Intelligent Systems,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 6, 2025
Micro/nanorobots
(MNRs)
are
untethered,
small‐scale
devices
designed
to
perform
complex
tasks
in
challenging
and
inaccessible
environments,
with
promising
biomedicine
environmental
remediation
applications.
Recent
advancements
multi‐module
MNRs,
which
incorporate
functional
components
such
as
actuators,
propellers,
imaging
modalities,
manipulators,
have
significantly
expanded
their
capabilities
while
addressing
the
limitations
of
single‐module
designs.
This
article
reviews
recent
progress
these
core
modules,
emphasizing
application
biomedicine,
including
targeted
drug
delivery,
tissue
repair,
diagnosis,
well
remediation,
pollutant
removal
microorganism
treatment.
It
highlights
practical
strategies
address
real‐world
challenges
domains,
a
focus
on
design
enhancing
functionality.
Despite
substantial
advancements,
key
persist,
scalability,
real‐time
imaging,
intelligent
control.
Future
research
directions
include
development
modules
equipped
memory,
data
processing,
communication
functions,
enabling
autonomous
decision‐making
closed‐loop
These
developments
hold
potential
foster
innovation
medicine,
sustainability,
other
critical
fields.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
17(2)
Published: March 1, 2025
ABSTRACT
Micro/nanorobots
are
being
increasingly
utilized
as
new
diagnostic
and
therapeutic
platforms
in
the
biomedical
field,
enabling
remote
navigation
to
hard‐to‐reach
tissues
execution
of
various
medical
procedures.
Although
significant
progress
has
been
made
development
micro/nanorobots,
how
achieve
closed‐loop
control
them
from
sensing,
memory,
precise
trajectory
planning
feedback
carry
out
tasks
remains
a
challenge.
Bacteria
with
self‐propulsion
autonomous
intelligence
properties
well
suited
be
engineered
microrobots
for
applications.
By
virtue
synthetic
biology,
bacterial
possess
an
expanded
genetic
toolbox,
allowing
load
input
sensors
respond
or
remember
external
signals.
To
accurate
complex
physiological
environment,
should
matched
corresponding
system
design.
In
this
review,
detailed
summary
sensing
mechanisms
is
presented.
The
engineering
applications
field
highlighted.
Their
future
directions
intelligent
precision
medicine
forecasted.
