Bioactive polymers: A comprehensive review on bone grafting biomaterials

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134615 - 134615

Published: Aug. 10, 2024

Language: Английский

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Insights of biopolymeric blended formulations for diabetic wound healing

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124099 - 124099

Published: April 16, 2024

Language: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Language: Английский

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Multi-functional Dressings for Recovery and Screenable Treatment of Wounds: A review

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41465 - e41465

Published: Dec. 24, 2024

Language: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541

Published: Nov. 1, 2024

Language: Английский

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Avanços, Desafios E Estratégias Em Terapias De Feridas: Abordagens Conservadoras, Tecnológicas E Biopoliméricas

Published: Jan. 14, 2025

Wound treatment represents a significant clinical challenge, requiring strategies that combine traditional approaches and technological innovations. The article analyzes advances in vacuum dressings, biopolymers nanotechnology-based materials, promoting faster more effective healing. research used an integrative literature review with databases such as PubMed, Scopus ScienceDirect, covering publications between 2019 2024. results highlight the use of Despite this, challenges remain, personalizing treatments adapting to different needs. combination methods emerging technologies has potential optimize care, accelerate tissue regeneration improve patients' quality life. study concludes integrated multidisciplinary approaches, combined new developments, are essential overcome barriers complex wounds.

Language: Английский

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PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 779 - 789

Published: Jan. 1, 2025

Treatment of severe burn wound injury remains a significant clinical challenge as serious infections/complex repair process and irregulating inflammation response. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have multidirectional differentiation potential could multiple injuries under appropriate conditions. Poly(L-lysine)-graft-4-hydroxyphenylacetic acid (PLL-g-HPA) hydrogel is an enzyme-promoted biodegradable in with good water absorption, biocompatibility anti-bacterial properties. Therefore, the aim this study was to evaluate therapeutic effect hUC-MSCs combined PLL-g-HPA on full thickness rat model. The developed characterized by Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), Hydrogen-1 nuclear magnetic resonance (H-NMR). cytotoxicity human foreskin fibroblasts (HFF) were assessed CCK-8 assay live/dead quantification antibacterial activity against Escherichia coli Staphylococcus aureus also detected colony forming unit. A full-thickness model 12 SD rats established, healing time/Histology/inflammation factor expression level. findings from SEM, FTIR, HFF analyses demonstrated successful synthesis hydrogels. These hydrogels exhibited low at minimal concentrations while maintaining excellent moisture retention Compared control group, treatment conjunction significantly enhanced healing, modulated inflammatory responses, promoted angiogenesis well re-epithelialization models. represents promising approach for management wounds.

Language: Английский

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Enhanced Wound Healing with Flaxseed Extract-Loaded Polyvinyl Alcohol Nanofibrous Scaffolds: Phytochemical Composition, Antioxidant Activity, and Antimicrobial Properties

Journal of Science Advanced Materials and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100862 - 100862

Published: Feb. 1, 2025

Language: Английский

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Nanohydrogel mediated approaches for wound healing

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 138

Published: Jan. 1, 2025

Language: Английский

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Bovine serum albumin-modified prussian blue nanoparticles enhance wound healing through the promotion of skin angiogenesis

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106833 - 106833

Published: March 1, 2025

Language: Английский

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