Lessons learnt from broad-spectrum coronavirus antiviral drug discovery

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: 19(9), P. 1023 - 1041

Published: July 30, 2024

Introduction Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East (MERS-CoV), and the most recent SARS-CoV-2 responsible for COVID-19 pandemic, pose significant threats to human populations over past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic distress syndromes (ARDS), resulting in high morbidity mortality.

Language: Английский

Association of IFNAR2 and TYK2 with COVID-19 pathology: current and future

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Language: Английский