Deciphering the Microbial Map and its implications in the therapeutics of Neurodegenerative Disorder DOI

Shrutikirti Vashishth,

Rashmi K. Ambasta, Pravir Kumar

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102466 - 102466

Published: Aug. 27, 2024

Language: Английский

White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes DOI Creative Commons
Naruchorn Kijpaisalratana, Chia‐Ling Phuah, Zsuzsanna Ament

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100086 - 100086

Published: Feb. 1, 2025

Language: Английский

Citations

0
Hesperetin-Enhanced Metformin to Alleviate Cognitive Impairment via Gut–Brain Axis in Type 2 Diabetes Rats DOI Open Access

Danyang Zhang,

Xiaoshi He,

Yinbo Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1923 - 1923

Published: Feb. 23, 2025

Diabetes constitutes a risk factor for cognitive impairment, whereas insulin resistance serves as the shared pathogenesis underlying both diabetes and decline. The use of metformin treating impairment remains controversial. present study found that hesperetin, flavanone derived from citrus peel, enhanced metformin's efficacy in reducing blood sugar levels, improving sensitivity, ameliorating diabetic rats. Additionally, it reduced required dosage to one-third its conventional dose. Transcriptome analysis 16S rRNA sequencing revealed activation cyclic-adenosine monophosphate response element binding protein (CREB)/brain-derived neurotrophic (BDNF) pathways benefited regulation gut microbiota promotion short-chain fatty acid (SCFA) producers such Romboutsia. Furthermore, this demonstrated hesperetin supplementation counteracted upregulation β-site amyloid precursor cleaving enzyme 1 (BACE1), pathological Alzheimer's disease (AD) was induced by metformin. Our findings reveal can be used supplementary treatment associated with diabetes.

Language: Английский

Citations

0
Nanobilosome as custom-tailored modality in addressing Alzheimer’s disease: advancements and translational glitches DOI

Biswabhusan Biswal,

Bhabani Sankar Satapathy, Laxmidhar Maharana

et al.

Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32

Published: April 11, 2025

Language: Английский

Citations

0
Anti-obesity effects of Monascus-fermented hawthorn and millet mixture on high-fat diet mice and its regulatory function on intestnal microbiota DOI

Yongchao Cai,

Zhi Lü,

Xue Dong

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106598 - 106598

Published: April 1, 2025

Language: Английский

Citations

0
Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer’s disease: A narrative review DOI Creative Commons

Anna Maggiore,

Valentina Latina, Maria D’Erme

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102578 - 102578

Published: Nov. 13, 2024

Alzheimer's Disease (AD) is the most common form of dementia among elderly people. This disease imposes a significant burden on healthcare system, society, and economy due to increasing global aging population. Current trials with drugs or bioactive compounds aimed at reducing cerebral Amyloid beta (Aβ) plaques tau protein neurofibrillary tangles, which are two main hallmarks this devastating neurodegenerative disease, have not provided results in terms their neuropathological outcomes nor met expected clinical end-points. Ageing, genetic environmental risk factors, along different symptoms suggest that AD complex heterogeneous disorder multiple interconnected pathological pathways rather than single entity. In present review, we highlight discuss various non-canonical, Aβ-independent mechanisms, like gliosis, unhealthy dietary intake, lipid sugar signaling, cerebrovascular damage contribute onset development AD. We emphasize challenging traditional "amyloid cascade hypothesis" may improve our understanding age-related syndrome help fight progressive cognitive decline

Language: Английский

Citations

3
From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment DOI Open Access

Mahathi Krothapalli,

Lauren Buddendorff,

Hariom Yadav

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6678 - 6678

Published: June 18, 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder and leading cause of dementia. Aging significant risk factor for AD, emphasizing the importance early detection since symptoms cannot be reversed once advanced stage reached. Currently, there no established method AD diagnosis. However, emerging evidence suggests that microbiome has an impact on cognitive function. The gut brain communicate bidirectionally through gut–brain axis, with systemic inflammation identified as key connection may contribute to AD. Gut dysbiosis more in individuals compared their cognitively healthy counterparts, increased permeability subsequent inflammation, potentially causing neuroinflammation. Detecting activity traditionally involves invasive expensive methods, but electroencephalography (EEG) poses non-invasive alternative. EEG measures multiple studies indicate distinct patterns Furthermore, mild impairment differ from those suggesting its potential indication This review aims consolidate existing knowledge biomarkers early-stage highlighting current state research avenues further investigation.

Language: Английский

Citations

2
Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats DOI
Yuchen Liu, Shengyi Chen, Yingying Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133898 - 133898

Published: July 15, 2024

Language: Английский

Citations

2
Amelioration of Serum Aβ Levels and Cognitive Impairment in APPPS1 Transgenic Mice Following Symbiotic Administration DOI Open Access
Chiara Traini, Irene Bulli,

Giorgia Sarti

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2381 - 2381

Published: July 23, 2024

Alzheimer’s disease (AD) is a neurodegenerative process responsible for almost 70% of all cases dementia. The clinical signs consist in progressive and irreversible loss memory, cognitive, behavioral functions. main histopathological hallmark the accumulation amyloid-ß (Aß) peptide fibrils brain. To date, origin Aß has not been determined. Recent studies have shown that gut microbiota produces Aß, dysbiotic states identified AD patients animal models AD. Starting from hypothesis maintaining or restoring microbiota’s eubiosis essential to control Aß’s production deposition brain, we used mixture probiotics prebiotics (symbiotic) treat APPPS1 male female mice, an model AD, 2 8 months age evaluated their cognitive performances, mucus secretion, Aβ serum concentration, composition. results showed treatment was able prevent memory deficits, reduced increased blood levels, imbalance found mice. present study demonstrates gut–brain axis plays critical role genesis impairment, modulation can ameliorate AD’s symptomatology.

Language: Английский

Citations

2
Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice DOI
Jun Ji, Xiangzhou Yi,

Xia Gao

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(9), P. 5419 - 5434

Published: Feb. 9, 2024

Cognitive impairment (CI) is a significant public health concern, and bioactive peptides have shown potential as therapeutic agents. However, information about their synergistic effects on cognitive function still limited. Here, we investigated the of tilapia head protein hydrolysate (THPH) walnut (WPH) in mitigating CI induced by scopolamine mice.

Language: Английский

Citations

2
Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication DOI Creative Commons
Fu Zhang, Xiuyan Yang,

Youheng Jiang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 26, 2024

The gut-brain axis is evident in modulating neuropsychiatric diseases including autism spectrum disorder (ASD). Chromosomal 16p11.2 microduplication dp/+ among the most prevalent genetic copy number variations (CNV) linked with ASD. However, implications of gut microbiota status underlying development ASD-like impairments induced by remains unclear. To address this, we initially investigated a mouse model , which exhibits social novelty deficit and repetitive behavior characteristic Subsequently, conducted comparative analysis microbial community metabolomic profiles between their wild-type counterparts using 16S rRNA sequencing liquid chromatography-mass spectrometry (LC/MS). Our revealed structural dysbiosis mice, characterized reduced biodiversity alterations species abundance, as indicated α/β-diversity analysis. Specifically, observed relative abundances Faecalibaculum Romboutsia accompanied an increase Turicibacter Prevotellaceae UCG_001 group. Metabolomic identified 19 significantly altered metabolites unveiled enriched amino acid metabolism pathways. Notably, disruption predominantly histamine-centered neurotransmitter network was mice. Collectively, our findings delineate potential correlations neurotransmitters providing new insights into pathogenesis treatment for CNV-associated

Language: Английский

Citations

1