Time-Restricted Feeding Attenuated Hypertension-Induced Cardiac Remodeling by Modulating Autophagy Levels in Spontaneously Hypertensive Rats

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Objective To investigate whether time-restricted feeding (TRF) can alleviate cardiac remodeling in spontaneously hypertensive rats (SHRs) by regulating autophagy levels. Methods A 16-week TRF intervention was conducted on Wistar Kyoto (WKY) and SHRs, with dietary intake confined to the interval from 9:00 am 5:00 pm each day. The study examined impact of blood pressure (BP), morphology function, expression levels key proteins involved its associated signaling cascades. Results significantly mitigated systolic (SBP), diastolic (DBP), mean (MBP) SHRs. Additionally, improved ejection fraction (EF) diminished interventricular septal thickness at end-diastole (IVS-d). further revealed that enhanced microtubule-associated protein-I light chain 3 (LC3-I), while reducing protein-II (LC3-II). Moreover, suppressed Beclin-1, phosphorylated phosphoinositide 3-kinase (p-PI3K), protein kinase B (p-AKT), mechanistic target rapamycin (p-mTOR) left ventricular (LV) tissues. Conclusion attenuate SHRs

Language: Английский

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Prospects for the Use of Amaranth Grain in the Production of Functional and Specialized Food Products

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1603 - 1603

Published: May 1, 2025

This review is dedicated to exploring recent advancements in the study of amaranth grain and presents research primarily on Amaranthus species such as cruentus, hypochondriacus, caudatus, a lesser extent hybridus, mantegazzianus, muricatus, tuberculatus, viridis, spinosus, tenuifoliu. Amaranth (Amaranthus spp.) promising, high-yield pseudocereal crop with significant commercial potential for developing functional food products. It contains wide range bioactive compounds, including squalene, tocopherols, phenolic phytates, vitamins, which possess important physiological properties. characterized by high levels starch, proteins, minerals, dietary fiber. Moreover, proteins are distinguished balanced amino acid composition exhibit greater resistance external factors compared animal-derived proteins. Grains free gliadin, making it valuable nutritional source individuals celiac disease, an immune-mediated disorder. Unlike traditional cereals, where prolamins glutelins dominate protein composition, pseudocereals like consist albumins globulins. The processing methods influence their quantitative qualitative often significantly improving physicochemical, antioxidant, functional, rheological work provides detailed analysis amaranth's chemical components, along its evaluation therapeutic preventive fractions (albumin, globulin, glutelin) squalene increased antioxidant activity, contributing notable radiation X-ray exposure. Bioactive compounds phytol, α-tocopherol, lunasin-like peptide (AhLun) anticancer properties have also been identified amaranth. Furthermore, six peptides were isolated from amaranth, which, according predictive models, demonstrate capacity inhibit angiotensin-converting enzyme (ACE) suggesting hypotensive effects. Certain considered promising ingredients prevention comprehensive treatment conditions diabetes, inflammatory bowel diseases, hypercholesterolemia, cardiovascular obesity. spp. processed products hold interest development innovative products, expansion enhancement value.

Language: Английский

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Dietary patterns and metabolic morbidities correlate among adolescents and young adults with HIV in Lagos, Nigeria: A cross-sectional study design

Journal of Multimorbidity and Comorbidity, Journal Year: 2025, Volume and Issue: 15

Published: May 1, 2025

Background The relationship between dietary patterns (DP) and health outcomes (elevated blood pressure, dyslipidaemia, hyperglycaemia, body mass index) among adolescents young adults (AYA) with HIV is not well understood. We aimed to identify determinants associated metabolic syndrome components living in Lagos, Nigeria. Methods conducted a cross-sectional study 180 participants at an ART clinic Lagos. Information on sociodemographic clinical characteristics, as 72-hour recall were collected. Anthropometric measurements (BMI (kg/m 2 )) pressure readings Blood samples assayed for fasting sugar lipid profiles. Statistical analysis was done using SPSS version 27, WHO Anthro Plus software. Results male-to-female ratio 1:1. Four major DPs identified DP 1 (higher consumption of beverages, vitamins, vegetables); (high intake minerals, fruits); DP3 carbohydrates, fat oil); DP4 alcohol vegetables). DP1 underweight BMI hyperglycaemia DP4, while DP2 had lower odds overweight elevated pressure. Conclusion This outcome provides valuable insights into their association co-morbidity AYA HIV. will inform nutritional counselling interventions promote quality life health.

Language: Английский

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Time-restricted feeding attenuated hypertension-induced cardiac remodeling by modulating autophagy levels in spontaneously hypertensive rats

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 15, 2025

To investigate whether time-restricted feeding (TRF) can alleviate cardiac remodeling in spontaneously hypertensive rats (SHRs) by regulating autophagy levels. A 16-week TRF intervention was conducted on Wistar Kyoto (WKY) and SHRs, with dietary intake confined to the interval from 9:00 am 5:00 pm each day. The study examined impact of blood pressure (BP), morphology function, expression levels key proteins involved its associated signaling cascades. Transmission Electron Microscopy (TEM) utilized further evaluate autophagic changes left ventricular (LV) tissues. significantly mitigated systolic (SBP), diastolic (DBP), mean (MBP) SHRs. Additionally, improved ejection fraction (EF) diminished interventricular septal thickness at end-diastole (IVS-d). revealed that enhanced microtubule-associated protein-I light chain 3 (LC3-I), while reducing protein-II (LC3-II). Moreover, suppressed Beclin-1, phosphorylated phosphoinositide 3-kinase (p-PI3K), protein kinase B (p-AKT), mechanistic target rapamycin (p-mTOR) LV TEM analysis confirmed could inhibit attenuate SHRs

Language: Английский

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Effect of Different Dietary Patterns on Cardiometabolic Risk Factors: An Umbrella Review of Systematic Reviews and Meta-Analyses

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3873 - 3873

Published: Nov. 13, 2024

Background/Objectives: Lifestyle interventions such as dietary changes have been proposed to control the cardiometabolic risk factors and thus prevent cardiovascular (CV) disease (CVD). We performed an umbrella review investigate whether different patterns affect CV in individuals with at least one factor (hypertension, dyslipidemia, obesity, diabetes, metabolic syndrome) but not established CVD. Methods: systematically searched PubMed Scopus databases (up August 2024) for systematic reviews meta-analyses of randomized controlled trials (RCTs). Articles should be written English refer a specific pattern (such Mediterranean diet, etc.). The population studied referred adults factor. Results: From 4512 records identified, we finally included 25 total 329 associations. Strong evidence benefit was found LCD reductions BW [MD: −4.79 (95% CI −5.85, −3.72) kg, p ≤ 0.001], SBP −6.38 −7.84, −4.93) mmHg, TG [WMD: −5.81 −7.96, −3.66) mg/dL, fasting plasma insulin −15.35 −19.58, −11.12) pmol/L, well low-GI diet reduction [SMD: −0.66 −0.90, −0.43) 0.001]. Conclusions: Across many patterns, showed strong or highly suggestive on SBP, reduction, lipid profile improvement. Secondarily, low-GI, DASH, Portfolio Nordic diets suggested beneficial effects controlling risk.

Language: Английский

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Hypertension in Pregnancy Among Immigrant and Swedish Women: A Cohort Study of All Pregnant Women in Sweden

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(5)

Published: Feb. 17, 2024

Background Little is known about risks of hypertensive disorders pregnancy in both first‐ and second‐generation immigrant women Europe other Western countries; such knowledge may help elucidate the influence genetic versus social factors on risks. We aimed to study for presence all types hypertension (preexisting hypertension, gestational preeclampsia, eclampsia) during pregnancy. Methods Results A cohort was conducted using data derived from Swedish National Birth Register, Patient Total Population Register. used Cox regression analysis compute hazard ratios (HRs) 99% CIs while adjusting sociodemographic comorbidities. The first‐generation included a total 1 084 212 deliveries 68 311 cases, 989 986 67 505 cases. fully adjusted HR (with CI) among 0.69 (0.66–0.72), women, it 0.88 (0.86–0.91), compared with Swedish‐born 2 parents. Women born Finland or parent(s) had higher risks, HRs (99% CIs) 1.30 (1.18–1.43) 1.12 (1.07–1.17), respectively. Conclusions Both overall lower women. However, risk reduction less pronounced suggesting that environmental Sweden have an important

Language: Английский

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Association Between Adherence to EAT-Lancet Diet and Risk of Hypertension: An 18-Year National Cohort Study in China

Journal of the American Nutrition Association, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Sept. 5, 2024

The EAT-Lancet Commission has proposed an diet (ELD), also known as a planetary health (PHD), which is environmentally sustainable and promotes human health. However, the association between this risk of hypertension remains unclear. This study aimed to determine whether adherence ELD was associated with lower hypertension.

Language: Английский

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Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3768 - 3768

Published: Nov. 2, 2024

Objective: To investigate the effects of licorice functional ingredient intake on blood pressure, explore its potential mechanisms action, and provide safety information for personalized nutritional interventions in special populations application licorice-derived foods. Methods: PubMed, Cochrane Library, Medline, Embase, EBSCO, ScienceDirect, Web Science databases were searched from inception to 31 August 2024. Randomized controlled trials (RCTs) investigating or components included. The range continuous variables was assessed using weighted mean difference (WMD) with 95% confidence intervals. Genes associated hypertension screened an online database. Machine learning, receiver operating characteristic(ROC) curve analysis, molecular docking, gene set enrichment analysis (GSEA) employed underlying licorice-induced pressure fluctuations. Results: Eight RCTs (541 participants) included meta-analysis, which indicated containing glycyrrhizic acid (GA) as main component increased systolic (SBP) diastolic (DBP) (SBP: WMD [95% CI] = 3.48 [2.74, 4.21], p < 0.001; DBP: 1.27 [0.76, 1.78], 0.001). However, dominated by flavonoids(LF) had no significant effect SBP DBP 0.58 [−1.15, 2.31], 0.511; 0.17 [−1.53, 1.88], 0.843). Three machine learning algorithms identified five biomarkers hypertension: calmodulin 3 (CALM3), cluster differentiation 9 (CD9), growth factor independence 1B transcriptional repressor (GFI1B), myosin light chain kinase (MYLK), Ras suppressor-1 (RSU1). After removing lower validity reliability, GFI1B, MYLK, RSU1 selected subsequent analysis. network toxicology results suggested that GA metabolite glycyrrhetinic may act RSU1, influencing fluctuations modulating nitrogen metabolism signaling pathways. Conclusions: There distinct differences pressure. Functional constituents shown increase both DBP, whereas those LF did not exhibit hypertensive mechanism involve modulation regulate metabolic

Language: Английский

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Economic and Cultural Assessment of the DASH Eating Plan for Low-Income African Americans: An Integrative Review

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(11), P. 1480 - 1480

Published: Nov. 7, 2024

Diet is one modifiable risk factor for hypertension. The low-sodium DASH (Dietary Approaches to Stop Hypertension) eating plan has been shown significantly reduce the of hypertension and cardiovascular disease. However, there a lack available health information on economic feasibility cultural acceptability low-income African American (AA) populations who are at most An integrative review was conducted summarize empirical literature AAs using these databases: PubMed, EMBASE, CINAHL Complete, AGRICOLA, Web Science Core Collection, ProQuest's Dissertations, Theses Citation Index, Google Scholar. Study elements from articles in final analysis were extracted. Eleven (11) published works met study's inclusion criteria. Major themes availability access healthy foods, impact obtaining material resources cooking, food literacy, plan. These findings suggest that cost familiarity inhibit benefiting Additional research needed develop pilot test low-cost, culturally sensitive plans AAs.

Language: Английский

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Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence

European Journal of Nutrition, Journal Year: 2024, Volume and Issue: 63(4), P. 1041 - 1058

Published: Feb. 20, 2024

Abstract Introduction This umbrella review aimed to investigate the evidence of an effect dietary intake total protein, animal and plant protein on blood pressure (BP), hypertension (PROSPERO: CRD42018082395). Methods PubMed, Embase Cochrane Database were systematically searched for systematic reviews (SRs) prospective studies with or without meta-analysis published between 05/2007 10/2022. The methodological quality outcome-specific certainty assessed by AMSTAR 2 NutriGrade tools, followed assessment overall evidence. SRs investigating specific sources are described in this review, but not included Results Sixteen considered eligible review. Ten investigated intake, six four vs. protein. majority reported no associations effects total, BP (all “possible” evidence), whereby uncertainty regarding was particularly high Two addressing milk-derived showed a reduction BP; contrast, soy found BP. mostly rated as low. Discussion/conclusion uncertainties whether there any from proteins, specifically. Based data two milk it cannot be excluded that certain types could favourably influence

Language: Английский

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