Maternal and Infant Characteristics and Pumping Profiles of Women That Predominantly Pump Milk for Their Infants

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 366 - 366

Published: Jan. 20, 2025

Background: Whilst it is inconvenient and time-intensive, predominantly (PP) exclusively pumping (EP) mothers rely on breast expression to provide milk for their infants ensure continued supply, yet these populations are poorly understood. Methods: We assessed characterised Western Australian PP (n = 93) regarding 24 h production (MP) infant intake demographics, perinatal complications breastfeeding difficulties, the frequencies of which were compared with published general population frequencies. Pumping efficacy flow parameters during a session in 32) those that pump occasionally (reference group, n 60). Results: had higher frequency pregnancy difficulties than population. Exclusive did not impact MP amount available infant. more ejections, longer active duration lower removal ratios; however, responsiveness (time first ejection), total duration, time stop pumping, percentage removed comfort different reference group. Conclusions: Despite reported challenges, when an effective used, predominant or exclusive does negatively affect Increasing awareness impacts women may assist health professionals early identification at high risk cessation breastfeeding, escalating postpartum intervention targeted support.

Language: Английский

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Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 191 - 191

Published: Jan. 15, 2025

Background/Objectives: The causes of low milk supply are multifactorial, including factors such as gene mutations, endocrine disorders, and infrequent removal. These affect the functional capacity mammary gland and, potentially, concentrations components. This study aimed to investigate differences in composition between mothers with normal develop predictive machine learning models for identifying supply. Methods: Twenty-four-hour production measurements were conducted using test-weigh method. An array components was measured 58 women (<600 mL/24 h) 106 (≥600 h). Machine algorithms employed prediction integrating maternal infant characteristics. Results: Among six tested, deep gradient boosting machines methods had best performance metrics. best-performing model, incorporating 14 characteristics, achieved an accuracy 87.9%, area under precision-recall curve (AUPRC) 0.893, receiver operating characteristic (AUC) 0.917. Additionally, a simplified optimised clinical applicability, maintained reasonable 78.8%, AUPRC 0.776, AUC 0.794. Conclusions: findings demonstrate potential predict high accuracy. Integrating characteristics offers practical approach identify at risk supply, facilitating timely interventions support breastfeeding ensure adequate nutrition.

Language: Английский

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Mammalian Lactation as a Framework for Teaching Development, Physiology, and Cell Biology for Social Change

Developmental Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women

Pharmacology Research & Perspectives, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 30, 2025

ABSTRACT Relugolix is an oral gonadotropin‐releasing hormone receptor antagonist that suppresses sex steroid hormones and approved as monotherapy for prostate cancer a fixed‐dose combination with estradiol/norethindrone the treatment of endometriosis uterine fibroids. The aim this postmarketing study was to determine pharmacokinetics quantify amount relugolix excreted into breast milk healthy lactating women. Following single, dose 40 mg relugolix, sampled over 120 h. Pharmacokinetic parameters were determined, including cumulative derive total infant dose. safety tolerability also assessed. Eight women enrolled completed per protocol. safe well tolerated based on adverse events other data. It median time peak concentration ( t max ) 5.81 h geometric mean C 15.7 ng/mL, similar corresponding plasma data from previous clinical studies. 0.0051 24 0.0067 h, 0.0128% 0.0167% maternal dose, respectively. body weight‐adjusted relative daily approximately 0.25% suggests 400‐fold lower newborn than exposure. Relevant effects breastfed child appear unlikely given its limited excretion but cannot be fully excluded in absence

Language: Английский

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Consecutive Lactation, Infant Birth Weight and Sex Do Not Associate with Milk Production and Infant Milk Intake in Breastfeeding Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1062 - 1062

Published: March 18, 2025

Background/Objectives: Optimal infant growth is reliant on the sufficient intake of human milk. Studies in animal models speculate that multiparous mothers produce a higher milk yield compared to primiparous mothers. We aimed examine if there are relationships between consecutive lactations and demographics both maternal 24 h production (MP) (MI). Methods: Lactating 1–6 months postpartum (n = 36; 25 fully breastfeeding (FBF), 11 supplementing with commercial formula (partly (PBF)) test-weighed their infants for during two provided demographic information. Twenty-four-hour MP by breast, MI (including mothers’ own expressed formula), expressing frequencies were measured. The statistical analysis used linear mixed modelling accounting birth weight (FBF) or time (PBF) random effect participant. Results: In FBF group, no differences terms (p 0.31) mother’s 0.14). was lactation 0.008). Infant sex not associated 0.12) 0.090). PBF frequency 0.042), 0.025) 0.019) whilst lower 0.004). Conclusions: This study suggests women, significant established lactation.

Language: Английский

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“Why Is There Not a Doctor that Knows Anything About This Part of My Body?” Patient Perspectives on Chronic Lactation Insufficiency

Breastfeeding Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Introduction: Although exclusive breastfeeding is recommended for the first six months of life, many lactating individuals discontinue due to low milk supply, a condition sometimes referred as chronic lactation insufficiency (CLI). Affecting an estimated 5-15% individuals, CLI can stem from both extrinsic factors (e.g., infant feeding challenges) and intrinsic ones endocrine or metabolic disorders). This qualitative study explored lived experiences with their interactions healthcare providers (HCPs). Methods: In-depth, semi-structured interviews were conducted 30 who self-reported experiencing 18 older, members "IGT Low Milk Supply Support Group" on Facebook, which has approximately 10,700 members. Data analyzed using phronetic iterative analysis cyclical, reflexive coding approach that emphasizes practical reasoning. Results: Participants reported significant challenges, including: (1) not being believed taken seriously; (2) facing discrepancies between led fragmented care; (3) lack knowledge HCPs, including consultants. Many described actively seeking diagnosis meaningful support but instead receiving inconsistent advice little no diagnostic insight into condition. Conclusions: These findings highlight urgent need improved education training among HCPs address complex realities CLI. They also point importance advancing personalized approaches expanding research determine causes diagnostics supply. By centering patient voices, this identifies critical gaps in care communication prevent effective those navigating

Language: Английский

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Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 30, 2025

Human milk oligosaccharides (HMOs) are a diverse group of complex carbohydrates that play crucial roles in infant health, promoting beneficial gut microbiota, modulating immune responses, and protecting against pathogens. Central to the synthesis HMOs glycosyltransferases, specialized class enzymes catalyse transfer sugar moieties form glycan structures characteristic HMOs. This review provides an in-depth analysis beginning with their classification based on structural functional characteristics. The catalytic activity these is explored, highlighting mechanisms by which they facilitate precise addition monosaccharides HMO biosynthesis. Structural insights into glycosyltransferases also discussed, shedding light how conformational features enable specific glycosidic bond formations. maps out key biosynthetic pathways involved production, including lactose, subsequent fucosylation sialylation processes, all intricately regulated glycosyltransferases. Industrial methods for synthesis, chemical, enzymatic, microbial approaches, examined, emphasizing role processes. Finally, discusses future directions glycosyltransferase research, particularly enhancing efficiency developing advanced analytical techniques better understand complexity biological functions

Language: Английский

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Using estrogen and progesterone to treat premenstrual dysphoric disorder, postnatal depression and menopausal depression

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

Female gonadal hormones, particularly estrogen and progesterone, are not only central to reproductive health but also play a crucial role in regulating mood, cognition, overall brain health. These hormones have significant impact on the nervous system, influencing key processes such as neurotransmission, neuroplasticity, development. Increasing evidence shows that hormonal fluctuations contribute onset progression of mental disorders disproportionately affect women, premenstrual dysphoric disorder (PMDD), postnatal depression (PND), menopausal depression. This paper explores current regarding neurobiological effects female discusses therapeutic approaches conditions PMDD, PND,

Language: Английский

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Understanding Insufficient Maternal Milk Production: Clinical Causes and Remedies

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Breastfeeding is universally recognized as the optimal form of infant nutrition, offering critical health benefits for both mother and child. Despite its importance, many mothers face challenges related to insufficient maternal milk production (IMMP), a multi-factorial issue influenced by physiological, psychological, environmental factors. This chapter explores clinical causes IMMP, emphasizing interplay hormonal, anatomical, behavioral factors that can disrupt lactation. Key contributors include endocrine disorders, breast conditions, issues, poor breastfeeding techniques, socio-cultural barriers. The importance early initiation, proper latch, frequent feeding sustain supply are also highlighted. Maternal hydration, use galactogogues discussed potential remedies enhance Additionally, addresses role healthcare providers in evidence-based interventions, such lactation support, nutritional guidance, emotional counseling, overcome challenges. By understanding underlying IMMP implementing targeted strategies, professionals empower achieve successful breastfeeding, ultimately improving outcomes. underscores need continued research, awareness, supportive policies promote cornerstone childhood development well-being.

Language: Английский

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Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(9)

Published: April 26, 2024

Abstract Botanicals and herbal supplements contain a diverse array of polyphenols that may affect mammary gland function promote galactagogue activity. This scoping review is conducted to identify scientific literature elucidating how biology cellular mechanisms critical for lactation. A search PubMed Medline reviews relevant studies in dairy animals, rodent models, cultured epithelial cells are published from January 2010 until July 2023, ascertain effects on regulating milk production composition. The PRISMA‐ScR (Preferred Reporting Items Systematic Reviews Meta‐Analyses Scoping Review) strategy applied 80 their implications composition included this review. Limited information delineating the molecular pathways lactation found, although available suggests modulation Stat5 signaling/differentiation, Stat3 signaling/remodeling, mTOR insulin signaling/energy production, nuclear factor kappa beta (NFκβ) signaling/oxidative stress inflammation play roles. profound lack mechanistic underscores need further research understand impact botanical humans establish maternal nutritional guidelines support breastfeeding goals.

Language: Английский

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