The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

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Impact of adherence to the Mediterranean diet on stroke risk

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Language: Английский

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Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

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Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 656 - 656

Published: Feb. 12, 2025

Long COVID has been associated with increased cardiovascular risk and chronic low-grade inflammation, raising concerns about its long-term metabolic consequences. Given that the Mediterranean diet (MD) shown beneficial effects on factors inflammation in various populations, it is important to explore potential impact individuals COVID. Therefore, aim determine association of MD (CVRF) syndrome (MetS) Caucasian subjects diagnosed Cross-sectional study, 305 were included following WHO criteria. Adherence was evaluated MEDAS (Mediterranean Diet Screener) 14 items used Prevention study (PREDIMED study). The criteria considered diagnose MetS blood pressure, glycemia, triglycerides, HDL cholesterol, waist circumference. Other CVRFs tobacco consumption, total LDL body mass index, baseline uric acid levels. between CVRF number components analyzed using multiple regression models multinomial regression. mean age 52.75 ± 11.94 years (men 55.74 12.22 women 51.33 11.57; p = 0.002), (68% women). questionnaire 7.76 2.37. presented 23.6% (39.8% men 15.9% < 0.001). In analysis, after adjusting for average time from acute COVID-19 infection date inclusion this score showed a negative (β -0.295; 95% CI: -0.496 -0.093), BMI -0.049; -0.096 -0.002), -0.210; -0.410 -0.010), circumference (WC) -0.021; -0.037 -0.003) positive cholesterol -0.018; 0.001 -0.037). findings suggest higher scores are lower levels acid, fewer components, smaller circumference,

Language: Английский

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Infection burden, periodontal pathogens, and their interactive association with incident all‐cause and Alzheimer's disease dementia in a large national survey

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6468 - 6485

Published: Aug. 8, 2024

Abstract INTRODUCTION Relationships and interplay of an infection burden (IB) periodontal pathogens or disease (Pd) markers with Alzheimer's (AD) all‐cause dementia among US adults were examined. METHODS Less than equal to 2997 participants from the National Health Nutrition Survey III linked CMS‐Medicare [≥45 years (1988‐1994); ≤30 follow‐up]. RESULTS Hepatitis C (hazard ratio = 3.33, p 0.004) herpes simplex virus 2 strongly associated greater risk. Porphyromonas gingivalis Streptococcus oralis AD risk at higher IB. The red‐green pathogen cluster coupled IB count increased minority racial groups. Pocket probing depth lower in overall sample. DISCUSSION Select viruses bacteria dementia, while interacted Pd relation these outcomes. Highlights Interplay was tested. ≤2997 NHANES Medicare. Tetanus sero‐positivity Red‐green high IB, minorities.

Language: Английский

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Reference dietary patterns in Portugal: Mediterranean diet vs Atlantic diet

Open Agriculture, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract Portugal is influenced by the Atlantic Ocean to west and Mediterranean Sea south. Thus, dietary patterns in include both diet (MD) (AD). This review examines characteristics of diets, highlighting their commonalities unique features. descriptive literature analyses scientific articles on MD AD. It addresses health effects diets based published evidence. includes a 15 studies specifically focused Portuguese population. Most were conducted with younger people (children or adolescents) older people, some made patients suffering from specific pathology, like heart disease, AIDS, macular degeneration. Both emphasize natural, local, seasonal foods prepared using traditional methods. They consist rich macronutrients, micronutrients, bioactive compounds that offer benefits. AD are recommended as healthy associated physical activity fundamental elements lifestyle promoting general well-being. While have been extensively studied, remains under-researched.

Language: Английский

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Potential Benefits of Kefir and its Compounds on Alzheimer's Disease: A Systematic Review

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: 10, P. 100115 - 100115

Published: March 16, 2025

Alzheimer's disease, characterized by the progressive loss of cognitive functions brain, is still an incurable pathology. Current treatments primarily aim to alleviate symptoms, acting mainly on behavioral changes, having a modest impact in disease course. Recently, potential role probiotics managing has been explored. Kefir, fermented food teeming with live microorganisms, thought influence gut microbiota, potentially reducing inflammation and accumulation toxic proteins brain. Additionally, kefir contains bioactive compounds, such as B vitamins, choline, folic acid, which are essential for neuronal health function. Thus, could emerge promising complementary treatment disease. This systematic review, conducted January 2024, examined effects both vivo animal models human patients neurodegenerative conditions. The review was based studies retrieved from BVS, Embase, PubMed/MEDLINE, Scopus, Web Science databases. Seven were included, involving invertebrates, murine models, participants. In primary outcomes antioxidant effects, reduced beta-amyloid deposition, attenuation vascular damage neurodegeneration. studies, supplementation resulted decreased levels inflammatory cytokines, reactive oxygen species (ROS), oxidative proteins, associated improvements memory. Given its benefits, serve valuable adjunct conventional warranting further investigation clinical settings.

Language: Английский

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The Benefits of Jaboticaba-Based Interventions on Disease: Metabolic, Cardiovascular, and Neurological Diseases

Published: Jan. 1, 2025

Language: Английский

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Proteomic insights into the MIND diet: bridging nutrition and dementia prevention

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: May 8, 2025

Cognitive impairment is a major public health concern. Nutrition literacy (NL) the capacity of an individual to make informed decisions about nutrition, which reflected in their eating behaviors and ultimately affects overall nutritional wellbeing. The association between NL cognitive unclear. A cross-sectional study was conducted among individuals aged 60 years above. evaluated via validated NL-12 scale, identified simplified 30-item Chinese Mini-Mental State Examination scale. examined binary logistic regression. Of 1,344 participants, 30.3% had impairment. Compared with those lowest quartile, highest quartile lower likelihood experiencing [odds ratio (OR) = 0.12, 95% confidence interval (CI) 0.07-0.20]. This relationship extends dimensions knowledge, understanding, obtaining, interactive, critical skills. Moreover, negative Q4 group impairment, compared that corresponding Q1 group, significant regardless age, sex, exercise status, socioeconomic status. association, however, only evident older adults who exhibited healthy behavior. Additionally, behavior significantly moderated interaction p value 0.018. Higher levels were associated odds adults, especially exhibiting healthier underscores importance enhancing as means mitigate adults. Future research should concentrate on examining interventions synergize lifestyle practices, ensuring seamless integration into daily routines address challenges effectively.

Language: Английский

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