Hydrogel-integrated graphene superstructures for tissue engineering: From periodontal to neural regeneration

Carbon, Journal Year: 2024, Volume and Issue: 223, P. 118970 - 118970

Published: Feb. 26, 2024

Hydrogel-integrated graphene superstructures (GSSs) represent a promising platform for applications in tissue engineering and regenerative medicine. Graphene, two-dimensional carbon-based material, possesses remarkable mechanical, thermal, electrical characteristics, making it strong candidate application biomedicine. Researchers have pursued the integration of with hydrogels, known their biocompatibility ability to provide conducive environment cellular growth, craft sophisticated scaffolds tailored needs. The hydrogels enables construction 3D frameworks that closely mimic natural extracellular matrix (ECM) found biological tissues. Hydrogels furnish biocompatible, well-hydrated environment, while component bolsters scaffold's mechanical integrity conductivity. This amalgamation enhances adhesion, differentiation, proliferation, thereby facilitating regeneration. A notable advantage hydrogel-integrated GSSs lies capacity support growth differentiation variety cell types such as PC12, MG-63, U-87, MC3T3-E1 lines. Overall, exhibit great potential advancing biomimetic combination unique properties development advanced scaffold systems Further research this domain will play crucial role medicine treatment various diseases injuries.

Language: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Language: Английский

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The Role of Polysaccharide-based Biodegradable Soft Polymers in the Healthcare Sector

Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.

Language: Английский

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3D Engineered scaffolds of conjugated polymers/metal organic frameworks for biomedical applications

International Materials Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The extracellular matrix can be replicated by 3D scaffolds, providing a favorable environment for cell growth, proliferation, and differentiation. Despite their biocompatibility, biodegradability, bioactivity, the poor mechanical strength of scaffolds limits use heavy loads. This creates bottleneck in supply with enhanced all previously mentioned characteristics. Conjugated polymers have emerged as promising option scaffold construction due to electrical conductivity, adjustable surface qualities, ability transfer bioactive molecules. Moreover, metal-organic frameworks (MOFs) are rapidly emerging class nanomaterials uniform porosity, excellent surface-to-volume ratio, variable diverse configurations, well tuanble chemical structures. While both conjugated polymer-based MOF-based suffer from drawbacks such low stability possible toxicity, combination is an imperative strategy construct desirable scaffols biomedical applications. Specific examples investigated polymer-MOF provided each area, along explanation synthesis, fabrication method, physicochemical properties. Finally, applications polymers/MOF tissue engineering cancer theragnostic reviewed, current challenges potential future directions discussed.

Language: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

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Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Tissue engineering (TE) has emerged as a promising therapeutic strategy, employing artificial scaffolds to regenerate functional cardiac tissue and offering new hope for innovative treatment approaches. A straightforward method producing biodegradable, conductive polymer-based composites involves blending polymers directly with biodegradable ones. This approach’s flexibility enables the development of diverse polymer scaffolds, which have been extensively explored in regenerative medicine. While this technique successfully combines advantages both types, it may face challenges such potential compromises conductivity biodegradability. review emphasizes tailor degradation rates by selecting appropriate types ratios, ensuring adaptability various biomedical applications.

Language: Английский

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Organic Mixed Ionic–Electronic Conductors Based on Tunable and Functional Poly(3,4-ethylenedioxythiophene) Copolymers

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28969 - 28979

Published: May 23, 2024

Organic mixed ionic–electronic conductors (OMIECs) are being explored in applications such as bioelectronics, biosensors, energy conversion and storage, optoelectronics. OMIECs largely composed of conjugated polymers that couple ionic electronic transport their structure well synthetic flexibility. Despite extensive research, previous studies have mainly focused on either enhancing ion conduction or enabling modification. This limited the number excel both domains. Here, a series based functionalized poly(3,4-ethylenedioxythiophene) (PEDOT) copolymers combine efficient ion/electron with versatility post-functionalization were developed. EDOT monomers bearing sulfonic (EDOTS) carboxylic acid (EDOTCOOH) groups electrochemically copolymerized different ratios oxygen plasma-treated conductive substrates. The plasma treatment enabled synthesis containing high EDOTS (up to 68%), otherwise not possible untreated flexibility resulted fabrication tunable properties terms conductivity (2–0.0019 S/cm) transport, for example, revealed by volumetric capacitances (122–11 F/cm3). importance organic nature amenable modification was also demonstrated. EDOTCOOH successfully post-functionalized without influencing copolymers. opens new way tailor specific applications, especially field bioelectronics.

Language: Английский

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Enhancing Osteoblast Differentiation from Adipose-Derived Stem Cells Using Hydrogels and Photobiomodulation: Overcoming In Vitro Limitations for Osteoporosis Treatment

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 6346 - 6365

Published: June 25, 2024

Osteoporosis represents a widespread and debilitating chronic bone condition that is increasingly prevalent globally. Its hallmark features include reduced density heightened fragility, which significantly elevate the risk of fractures due to decreased presence mature osteoblasts. The limitations current pharmaceutical therapies, often accompanied by severe side effects, have spurred researchers seek alternative strategies. Adipose-derived stem cells (ADSCs) hold considerable promise for tissue repair, albeit they encounter obstacles such as replicative senescence in laboratory conditions. In comparison, employing ADSCs within three-dimensional (3D) environments provides an innovative solution, replicating natural extracellular matrix environment while offering controlled cost-effective vitro platform. Moreover, utilization photobiomodulation (PBM) has emerged method enhance ADSC differentiation proliferation potential instigating cellular stimulation facilitating beneficial performance modifications. This literature review critically examines shortcomings osteoporosis treatments investigates synergies between 3D cell culture PBM augmenting towards osteogenic lineages. primary objective this study assess efficacy combined enhancing management. research notably distinguished its thorough scrutiny existing literature, synthesis recent advancements, identification future trajectories, databases PubMed, Scopus, Web Science, Google Scholar review. Furthermore, exploration biomechanical biophysical stimuli holds refining treatment outlook suggests integrating with housed advancing regeneration efforts. Importantly, aspires catalyse further advancements therapeutic strategies regeneration.

Language: Английский

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Recent trends on polycaprolactone as sustainable polymer-based drug delivery system in the treatment of cancer: Biomedical applications and nanomedicine

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124734 - 124734

Published: Sept. 28, 2024

Language: Английский

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Design and Characterization of pH-Responsive DGEA-Derived Peptide Scaffolds: A Comprehensive Molecular Dynamics Simulation Study

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Peptide-based, functionally active, stimuli-responsive biomaterials hold immense potential for diverse biomedical applications. Functionally active motifs of extracellular matrix (ECM) proteins, when conjugated with self-assembling peptides (SAP) or polymers, demonstrate significant promise in the development such bioactive scaffolds. However, synthesis complexity, high associated costs, limited functionality, and immune responses present challenges. This study explores collagen-I-derived DGEA motif-based SAPs, incorporating modifications as salt bridge pairing, charged polar residues, hydrophobic amyloidogenic sequences, non-ECM motifs, to develop stimuli-responsive, Extensive molecular dynamics (MD) simulations, totaling 16.7 μs, were conducted on 20 systematically designed peptide systems. These simulations also characterized properties peptides, focusing pH temperature responsiveness. Among designs, three systems─DGEA-SBD, DGEA-SBE (salt-bridge modifications), DGEA-F4 (with residue addition at C-terminus)─successfully formed large, stable, systems exhibited enhanced aggregation (greater than 90%) improved interpeptide hydrogen bonding (more 30 bonds) while maintaining accessibility functional (60–70% availability) compared unmodified motif. Notably, DGEA-SBD showed a transition from small, unstable, uneven gel-like structures uniform, scaffolds shifted 3.0 physiological pH. Comprehensive MD simulation studies demonstrated that these exhibit increased retaining their activity under various conditions, highlighting promising

Language: Английский

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