Natural Regenerative Hydrogels for Wound Healing

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 547 - 547

Published: Aug. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Language: Английский

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Advancements in nanocomposite hydrogels: a comprehensive review of biomedical applications

Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 28, 2024

Nanocomposite hydrogels (NHs) have emerged as a groundbreaking tool in biomedical applications, offering remarkable versatility and efficacy. Integrating wide range of nanoparticles, including carbon-based, polymeric, ceramic, metallic nanomaterials, within hydrogel networks results nanocomposites with superior properties tailored functionalities. Recent research has highlighted their potential to address key challenges drug delivery, cancer therapy, tissue regeneration, biosensing, wound healing, outstanding biocompatibility bioavailability. Nanohydrogels demonstrate significant promise delivery systems biological sensors, providing sustained therapeutic activity at targeted sites. This reduces the frequency administration minimizes harmful side effects. In healthcare sector, they applications ranging from therapy aesthetic corrections are leading topic regeneration research. comprehensive review Biomedical Applications investigates latest advancements NHs, focusing on classification, unique properties, diverse applications. By identifying future prospects existing gaps, this aims highlight diagnostic nanocomposite technology, covering way for further advancement field.

Language: Английский

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A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

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Hydrogels with Essential Oils: Recent Advances in Designs and Applications

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 636 - 636

Published: Sept. 30, 2024

The innovative fusion of essential oils with hydrogel engineering offers an optimistic perspective for the design and development next-generation materials incorporating natural bioactive compounds. This review provides a comprehensive overview latest advances in use hydrogels containing biomedical, dental, cosmetic, food, food packaging, restoration cultural heritage applications. Polymeric sources, methods obtaining, cross-linking techniques, functional properties are discussed. unique characteristics polymer agents highlighted. These include biocompatibility, nontoxicity, effective antibacterial activity, control sustained prolonged release active substances, optimal porosity, outstanding cytocompatibility. Additionally, specific distinctive explored, along their extraction encapsulation methods. advantages disadvantages these also We have considered limitations due to volatility, solubility, environmental factors, stability. importance loading hydrogels, stability, biological activity is analyzed. highlights through in-depth analysis, recent innovations, challenges, future prospects encapsulated potential multiple applications including biomedicine, dentistry, cosmetics, conservation.

Language: Английский

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Comprehensive Exploration on Chemical Functionalization and Crosslinked Injectable Hyaluronic Acid Hydrogels for Tissue Engineering Applications

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 131 - 131

Published: Feb. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Language: Английский

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Applications of Hydrogels in Emergency Therapy

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234

Published: March 23, 2025

Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.

Language: Английский

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Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4360 - 4360

Published: Sept. 13, 2024

Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key are especially valuable use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, and pH stimuli-sensitive swelling. These features offer advantages such as enhanced healing, promotion granulation tissue formation, facilitation neutrophil migration. As a result, CMCS favorable materials applications biopharmaceuticals, drug delivery systems, wound engineering, more. Understanding the interactions between biological with focus on influence cellular behavior, is crucial leveraging versatility. Because constantly growing interest its derivative applications, present review aims to provide updated insights into potential based recent findings. Additionally, we comprehensively elucidated mechanisms underlying actions these settings. In summary, this paper recapitulates data gathered from current literature, offering perspectives further development utilization carboxymethyl contexts.

Language: Английский

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Injectable Biodegradable Chitosan–PEG/PEG–Dialdehyde Hydrogel for Stem Cell Delivery and Cartilage Regeneration

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 508 - 508

Published: Aug. 1, 2024

Stem cell-based therapy holds promise for cartilage regeneration in treating knee osteoarthritis (KOA). Injectable hydrogels have been developed to mimic the extracellular matrix (ECM) and facilitate stem cell growth, proliferation, differentiation. However, these face limitations such as poor mechanical strength, inadequate biocompatibility, suboptimal biodegradability, collectively hindering their effectiveness regeneration. This study introduces an injectable, biodegradable, self-healing hydrogel composed of chitosan–PEG PEG–dialdehyde delivery. can form situ by blending two polymer solutions through injection at physiological temperature, encapsulating human adipose-derived cells (hADSCs) during gelation process. Featuring a 3D porous structure with large pore size, optimal properties, easy injectability, rapid capability, supports differentiation hADSCs. Notably, encapsulated hADSCs spheroids sizes increasing over time alongside degradation while maintaining high viability least 10 days. Additionally, this exhibit upregulated expression chondrogenic genes proteins compared those cultured on 2D surfaces. These characteristics make chitosan–PEG/PEG–dialdehyde hydrogel–stem construct suitable direct implantation minimally invasive injection, enhancing KOA other treatments.

Language: Английский

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A Comprehensive Review on the Utilization of Biomaterials for Bio-Based Hydrogel in Therapeutic Applications

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

A bio-based hydrogel is a complex compound that consists of natural biomaterials and widely applied for various therapeutic purposes. The modification from traditional to reformulated hydrogels has gained place at biomedical field due the growth benefits such as drug delivery, tissue engineering, regenerative medicine. Moreover, increasing global demand resulted in worldwide shortage mass formulations raised environmental awareness. By using instead synthetic ones, these minimize their negative effects on environment while simultaneously maximizing successful execution product. However, mechanisms governing degradation bioactivity hydrogels, which dictate release profiles, stability, effectiveness, are not yet comprehensively understood. Therefore, by analyzing recent progress ongoing challenges, this review will reveal how advanced quietly transforming future healthcare offering novel solutions pressing health problems.

Language: Английский

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