Abnormal Serum Levels of Liver Enzyme Markers and Related Risk Factors in Type 2 Diabetes Mellitus Patients Attending the Buea Regional Hospital, Cameroon DOI
Arnaud Fondjo Kouam,

Saturine Mengwe Mofor,

Madeleine Yvanna Nyangono Essam

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Objectives: The prevalence of type 2 Diabetes Mellitus (T2DM) is increasing globally, leading to complications, including liver damage. This study aims examine serum biomarkers injury and the related risk factors in T2DM patients at Buea Regional Hospital, Cameroon Methods: sociodemographic, clinical, behavioral characteristics with were captured using a structured questionnaire. Anthropometric parameters measured, Body Mass Index was calculated. Blood samples analyzed for damage (ALT, AST, GGT, ALP), considering enzyme profile abnormal if it had more than abnormally elevated values. Bivariate multivariate logistic regressions analysis used identify factors, significance set P<0.05. Results: Among 170 participants recruited, 75.9% female. median age 62 years. Over half (52.9%) married, 64.7% attended primary school, 55.3% retired. Also, 59.4% diabetes over five years, all reported knowledge care. About 73.3% adhered their medication, consumed alcohol, 28.8% smoked tobacco, 22.4% engaged physical activity, 77.6% comorbidities. sugar monitoring practiced by 80%, 66.5% having high blood pressure. Healthy weight individuals 31.2%, while 41.2% obese 56.5% profiles. Five factors: duration illness, inactivity, tobacco smoking, comorbidities, overweight/obesity significantly (P<0.05) associated profile. Conclusion: Our findings linked markers indicating patients.

Language: Английский

Impact of green space and built environment on metabolic syndrome: A systematic review with meta-analysis DOI
Muhammad Mainuddin Patwary, Mohammad Javad Zare Sakhvidi, Sadia Ashraf

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 170977 - 170977

Published: Feb. 14, 2024

Language: Английский

Citations

12
Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update DOI Creative Commons
Imadeldin Elfaki, Rashid Mir, Mohamed E. Elnageeb

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 83 - 83

Published: Jan. 7, 2025

Metabolic syndrome is a metabolic disorder characterized by hypertension, dyslipidemia, impaired glucose tolerance, and abdominal obesity. Impaired insulin action or resistance initiates syndrome. The prevalence of increasing all over the world. Insulin results in defective metabolism carbohydrates lipids, addition to low-grade chronic inflammation. associated with syndrome, which risk factor for number pathological conditions, such as Type 2 diabetes (T2D), cardiovascular disease (CVD), nonalcoholic fatty liver (NAFLD), polycystic ovarian (PCOS). Genome-wide association studies have increased our understanding many loci linked these diseases others. In this review, we discuss its contribution diseases. We also genetic them. Genetic testing invaluable identification stratification susceptible populations and/or individuals. After individuals been identified via screening, lifestyle modifications regular exercise, weight loss, healthy diet, smoking cessation can reduce prevent pathologies.

Language: Английский

Citations

1
Mitigating the Impact of High-Fat Diet: The Role of Metformin and Exercise Interventions in Alleviating Autism-Like Behaviors and Insulin Resistance in Mice DOI
Zohreh Rahimi, Ayoob Sabaghi,

Ershad Nedaei

et al.

Journal of Science in Sport and Exercise, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

1
The interface of depression and diabetes: treatment considerations DOI Creative Commons
Giuseppe Fanelli, Emanuel Raschi, Gaye Hafez

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

This state-of-the-art review explores the relationship between depression and diabetes, highlighting two-way influences that make treatment challenging worsen outcomes of both conditions. Depression diabetes often co-occur share genetic, lifestyle, psychosocial risk factors. Lifestyle elements such as diet, physical activity, sleep patterns play a role on development management conditions, need for integrated strategies. The evidence suggests traditional strategies focusing either condition in isolation fall short addressing intertwined nature depression. Instead, care models encompassing psychological support medical are recommended to improve efficacy patient adherence. Such require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, primary care, offer holistic approach care. also identifies significant patient-related barriers effective management, stigma, resistance, health literacy, which be addressed through patient-centered education systems. Future directions research include longitudinal studies diverse populations further elucidate causal relationships exploration novel therapeutic targets, well effectiveness aimed at preventing onset one individuals diagnosed with other.

Language: Английский

Citations

1
Mediating roles of perceptions and visiting behavior in the relationship between urban greenspace accessibility and personal health: Evidence from Lanzhou, China DOI
Liang Ma,

Wenqian Shi,

Longfeng Wu

et al.

Applied Geography, Journal Year: 2023, Volume and Issue: 159, P. 103085 - 103085

Published: Aug. 29, 2023

Language: Английский

Citations

13
Impact of Concurrent Exercise Training on Cardiac Autonomic Modulation, Metabolic Profile, Body Composition, Cardiorespiratory Fitness, and Quality of Life in Type 2 Diabetes with Cardiac Autonomic Neuropathy: A Randomized Controlled Trial DOI Open Access
Saima Zaki,

Md Farhan Alam,

Saurabh Sharma

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(13), P. 3910 - 3910

Published: July 3, 2024

Background: Type 2 diabetes mellitus (T2DM) often leads to cardiac autonomic neuropathy (CAN), a severe complication affecting cardiovascular health. Exercise training is proven intervention for improving metabolic control and health in T2DM, but the effects of concurrent exercise (CET), combining aerobic resistance exercises, on CAN are not fully understood. Objective: This randomized controlled trial investigates impact structured CET program modulation, profile, body composition, cardiorespiratory fitness (CRF), quality life (QoL) individuals with T2DM CAN. Methods: A total 96 participants, aged 35-70 years, CAN, were into (n = 48) groups. The group engaged combined three times per week 13 weeks, while received standard care. Primary outcomes included heart rate variability (HRV) recovery (HRR). Secondary CRF, QoL, which assessed using standardized protocols validated questionnaires. was registered Clinical Trials Registry-India (CTRI/2021/09/036711). Results: Significant improvements noted compared controls. HRV metrics (SDNN, RMSSD, pNN50, TP, LF power, HF LF/HF ratio) HRR (HRR30s, HRR1, HRR2, HRR3) all showed significant enhancements (p < 0.01). also exhibited substantial reductions fasting blood glucose, postprandial HbA1c, waist circumference, hip percentage fat Improvements observed lipid profile markers CRF (VO2max) QoL scores improved significantly as ADDQoL-19 Conclusions: enhances These findings support integration management improve clinical QoL. Further research needed explore long-term benefits broader applicability diverse diabetic populations.

Language: Английский

Citations

6
Gender differences in dietary patterns and physical activity: an insight with principal component analysis (PCA) DOI Creative Commons
Alessandra Feraco, Stefania Gorini,

Elisabetta Camajani

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 18, 2024

Gender differences in dietary patterns and physical activity are known to influence metabolic health, but research exploring these using principal component analysis (PCA) is limited. This study aims identify distinct of eating behaviour, body composition between men women, order develop tailored interventions. A cross-sectional was conducted on 2,509 adults attending a health centre. Data habits, were collected by means questionnaires bioimpedance analysis. PCA used behaviour activity. Statistical analyses performed explore gender-specific differences. Based the PCA, five groups participants identified: Balanced Eaters, Focused Home Cooking, Routine Restaurant Lovers Varied Eaters. Significant gender food preferences observed, with consuming more meat women vegetables. Men also reported greater participation strength endurance sports, while showed structured routine. study, (PCA), revealed diet, composition. identified behavioural groups, revealing that tended consume engage training, adhered structured, vegetable-rich diets. The application provided insight than traditional analysis, highlighting complexity behaviour. These results emphasize need for interventions, focusing increasing vegetable intake encouraging training women. Future should exploit longitudinally refined personalised strategies. registered ClinicalTrials.gov (NCT06654674).

Language: Английский

Citations

6
Can pharmaceutical care decrease the oxidative stress in type 2 diabetes mellitus? DOI Open Access

Angélica Marchesi Lira-Meriguete,

Mayara Paes Santos,

Vivian Cerqueira de Souza Viana

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116178 - 116178

Published: Jan. 24, 2024

Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder characterized by an increase in oxidative stress, which itself related to development of T2D’s main complications. Oxidative stress caused elevated production reactive species oxygen and decrease antioxidant defense system level, leads activation lipid peroxidation (LPO) lipoprotein modification with increasing atherogenicity. Therefore, the aim this study was evaluate whether pharmacotherapeutic follow-up patients T2D, users non-users insulin, interferes levels measuring protein oxidation, nitric oxide superoxide dismutase levels. After follow-up, there concentration for group insulin therapy. Accordingly, these results show that proposed pharmaceutical care program reduced levels, mainly therapy, as consequence, can impact surging complications T2D.

Language: Английский

Citations

4
Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review DOI Creative Commons
Samradhi Singh, Mona Kriti,

Anamika K.S.

et al.

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100287 - 100287

Published: May 19, 2024

The complex and multidimensional landscape of type 2 diabetes mellitus (T2D) is a major global concern. Despite several years extensive research, the precise underlying causes T2D remain elusive, but evidence suggests that it influenced by myriad interconnected risk factors such as epigenetics, genetics, gut microbiome, environmental factors, organelle stress, dietary habits. number influencing pathogenesis increasing day which worsens scenario; meanwhile, interconnections shoot up frame. By gaining deeper insights into contributing we may pave way for development personalized medicine, could unlock more impactful treatment pathways individuals with T2D. This review summarizes state knowledge about pathogenesis, focusing on interplay between various their implications future therapeutic strategies. Understanding these lead to tailored treatments targeting specific inform prevention efforts population level, ultimately improving outcomes reducing its burden globally.

Language: Английский

Citations

4
The effectiveness of diet and exercise in the management of obesity DOI Creative Commons

Nuridin Widya Pranoto,

Varhatun Fauziah,

Septriyan Anugrah

et al.

Retos, Journal Year: 2024, Volume and Issue: 58, P. 951 - 959

Published: July 16, 2024

Background and objectives: Obesity is a growing global health problem becoming significant challenge in the clinical public fields. One of main concerns impact on an individual's quality life. This review aims to evaluate effectiveness various interventions, including physical activity diet, management obesity. Methodology: The selected studies involved population adults who were obese (aged 18 years over) had made lifestyle modifications through pattern changes, eating, activity, or both. A total 324 articles screened, which 25 duplicates. After screening process for suitability, 261 excluded. further 27 excluded due inappropriate study design incomplete data. 11 full-text then reviewed included our analysis. results showed that participants followed milk-based diet recorded decrease body weight -1.16 kg (confidence interval -1.66, -0.66 kg; p < 0.001) as well fat mass -1.49 -2.06, -0.92 0.001). Participants adopted alternate day fasting (ADF) eating achieved average loss -0.9% ± 0.6% low group -9.9% 1.1% group. Meanwhile, restricted calorie intake (Caloric Restriction/CR) -1.3% 0.7% -9.2% 1.2% tall body. Combining approximately 175 minutes intense per week with controlled up 5%. In conclusion, this systematic confirms most effective approach obesity combination strength cardiovascular training at least low-calorie tailored metabolic needs condition. Keywords: management; exercise efficacy; treatment;

Language: Английский

Citations

4