Deoxycholic acid inhibits Staphylococcus aureus-induced endometritis through regulating TGR5/PKA/NF-κB signaling pathway DOI

Weiliang Zhao,

Junrong Wang,

Xiaojie Li

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110004 - 110004

Published: March 21, 2023

Language: Английский

Is There Evidence to Support Probiotic Use for Healthy People? DOI Creative Commons
Daniel Merenstein, Daniel J. Tancredi, J. Philip Karl

et al.

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(8), P. 100265 - 100265

Published: July 6, 2024

Probiotics are typically marketed as foods and dietary supplements, categories for products intended to maintain health in generally healthy populations which, unlike drugs, cannot claim treat or cure disease. This review addresses the existing evidence that probiotics beneficial people. Our approach was perform a descriptive of efficacy can prevent urinary, vaginal, gastrointestinal, respiratory infections, improve risk factors associated with cardiovascular reduce antibiotic use. Other endpoints such mental, dental, immune were not specifically addressed. We concluded there is sufficient safety clinicians consumers consider using specific some indications - use support gut function during tract infections certain However, we did find sufficiently high level unconditional, population-wide recommendations other preventive reviewed Although suggestive benefits probiotics, additional research needed.

Language: Английский

Citations

6
Effect of bacterial vaginosis on preterm birth: a meta-analysis DOI
Trishna Mohanty, Prakash Prabhakarrao Doke, Sana Rafiq Khuroo

et al.

Archives of Gynecology and Obstetrics, Journal Year: 2022, Volume and Issue: 308(4), P. 1247 - 1255

Published: Oct. 17, 2022

Language: Английский

Citations

26
Mechanistic Insights into Immune Suppression and Evasion in Bacterial Vaginosis DOI Creative Commons
Emmanuel Amabebe, Dilly Anumba

Current Microbiology, Journal Year: 2022, Volume and Issue: 79(3)

Published: Feb. 7, 2022

Abstract The immunological response to bacterial vaginosis (BV) remains poorly understood and recurrent BV is still a major public health burden especially in the pregnant population. This article reviews potential mechanisms by which BV-associated bacteria suppress circumvent host microbial defence responses, propagate their survival/dominance without overt inflammation. We discuss composition of cervicovaginal mucosal barrier mechanism circumvents defence: degradation immunoglobulin A (IgA); organism Gardnerella vaginalis haemolysin (vaginolysin); diminished IgA against vaginolysin; sialic acid degradation, foraging depletion; inhibition IL-8-induced neutrophilic infiltration; metabolite-induced incapacitation neutrophil monocyte chemotaxis. also highlight tolerance/resistance both antimicrobial molecules mounted biofilms. plausible role acid-binding immunoglobulin-like lectins (SIGLECS) was suggested. Sialidase, often produced G. , central immunosuppression, relapse recurrence observed BV, although it supported other hydrolytic enzymes, vaginolysin immunomodulatory metabolites.

Language: Английский

Citations

23
Review of the evidence of the effects of human papillomavirus infection and Gardnerella vaginalis, and their co-infection on infertility DOI
Omid Gholizadeh,

Zahra Yekanipour,

Setareh Kivi

et al.

Microbial Pathogenesis, Journal Year: 2023, Volume and Issue: 175, P. 105980 - 105980

Published: Jan. 12, 2023

Language: Английский

Citations

14
Deoxycholic acid inhibits Staphylococcus aureus-induced endometritis through regulating TGR5/PKA/NF-κB signaling pathway DOI

Weiliang Zhao,

Junrong Wang,

Xiaojie Li

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110004 - 110004

Published: March 21, 2023

Language: Английский

Citations

14