Luteolin attenuates Staphylococcus aureus -induced endometritis through inhibiting ferroptosis and inflammation via activating the Nrf2/GPX4 signaling pathway

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(2)

Published: Jan. 3, 2024

Endometritis, a local inflammatory disease, has been known as the most common cause of infertility in mares. In this study, we investigated protective effects luteolin on endometritis induced by

Language: Английский

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Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2838 - 2838

Published: Aug. 24, 2024

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds millions years. Over the past decade, growing body knowledge has underscored intricate connections among diet, microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, fungi diverse biological functions including antioxidant, immunoregulatory, metabolic activities. Their effects are closely tied to which metabolizes BPs into health-influencing compounds. Understanding how interact is critical for harnessing potential health benefits. This review provides an overview focusing on its role in diseases obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular diseases. It explores basic characteristics several impact microbiota. Given significance health, we summarize these BPs, particularly terms immunoregulatory activities, blood sugar, hypolipidemic effect, thus providing valuable reference understanding benefits treating These properties make promising agents preventing comprehensive mechanisms by exert through opens new avenues developing targeted therapies improve

Language: Английский

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Update on the development of TGR5 agonists for human diseases

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 271, P. 116462 - 116462

Published: April 28, 2024

Language: Английский

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Non-targeted LC-MS metabolomics reveals serum metabolites for high-altitude adaptation in Tibetan donkeys

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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The possible pathogenic mechanisms of microorganisms in infertility: a narrative review

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(2)

Published: Jan. 8, 2025

Language: Английский

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Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Strategic Interventions for Infections

Published: June 27, 2024

Bile acids (BAs) play a crucial role in the human body's defense against infections caused by bacteria, fungi, and viruses. BAs counteract not only through interactions with intestinal bacteria exhibiting bile salt hydrolases (BSHs) activity but also directly combat infections. Building upon our research group's previous discoveries highlighting of combating infections, we have initiated an in-depth investigation into between microbiota. Leveraging existing literature, offer comprehensive analysis relationships 16 key This encompasses (e.g., Clostridioides difficile, Staphylococcus aureus, Escherichia coli, Enterococcus, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Bacteroides, Clostridium scindens, Streptococcus thermophilus, Saccharomyces boulardii, butyricum, Lactic Acid Bacteria), fungi Candida albicans), viruses Coronavirus SARS-CoV-2, influenza virus, norovirus). Our underscores critical interplay microbiota, including Bacteria, maintaining homeostasis It is imperative to note that Primary acid (PBA) Secondary (SBA) often exhibit distinct roles anti-infection process. In antimicrobial action BAs, SBA demonstrate antagonistic properties wide range exception Norovirus. Given intricate their regulatory effects on assert hold significant potential as novel approach for preventing treating microbial

Language: Английский

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Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections

Pathogens, Journal Year: 2024, Volume and Issue: 13(8), P. 702 - 702

Published: Aug. 20, 2024

Bile acids (BAs) play a crucial role in the human body's defense against infections caused by bacteria, fungi, and viruses. BAs counteract not only through interactions with intestinal bacteria exhibiting bile salt hydrolase (BSH) activity but they also directly combat infections. Building upon our research group's previous discoveries highlighting of combating infections, we have initiated an in-depth investigation into between microbiota. Leveraging existing literature, offer comprehensive analysis relationships 16 key This encompasses (e.g.,

Language: Английский

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Caffeic acid inhibits Staphylococcus aureus‐induced endometritis through regulating AMPKα/mTOR/HIF‐1α signalling pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(20)

Published: Oct. 1, 2024

Abstract Endometritis is mostly caused by childbirth or postpartum uterine infection. It one of the important reasons leading to female infertility. Caffeic acid (CA) and its derivatives are widely found in some foods traditional Chinese medicine, have biological activities such as antioxidant, free radical scavenging, anti‐inflammatory, anti‐infection. In this study, we aimed explore effect CA on Staphylococcus aureus ‐induced endometritis. The contents TNF‐α IL‐1β were detected ELISA S. endometritis model. Western blot assay was used detect expression AMPKα/mTOR/HIF‐1α pathway related proteins GPX4 expression. addition, concentrations MDA, GSH, iron tested kits. Compared with model group, treatment significantly alleviated injury, MPO activity, inflammatory factors IL‐1β, NF‐κB activation. Meanwhile, inhibited ferroptosis, confirmed decreased MDA concentration up‐regulated GSH level. Furthermore, attenuated HIF‐1α phosphorylated mTOR increased AMPK conclusion, inhibits inflammation ferroptosis regulating signalling alleviate mice.

Language: Английский

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Bioactivities, Mechanisms, Production, and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases

Engineering, Journal Year: 2024, Volume and Issue: 38, P. 13 - 26

Published: Feb. 7, 2024

Infectious diseases are a global public health problem, with emerging and re-emerging infectious on the rise worldwide. Therefore, their prevention treatment still major challenges. Bile acids common metabolites in both hosts microorganisms that play significant role controlling metabolism of lipids, glucose, energy. have historically been utilized as first-line, valuable therapeutic agents for related metabolic hepatobiliary diseases. Notably, bile active ingredients cow bezoar bear bile, which commonly used traditional Chinese medicines (TCMs) effects clearing heat, detoxification, relieving wind spasm. In recent years, promising performance against has attracted attention from scientific community. This paper reviews first time biological activities, possible mechanisms, production routes, potential applications Compared previous reviews, we comprehensively summarize existing studies use caused by pathogenic leading causes morbidity mortality. addition, to ensure stable supply at affordable prices, it is necessary clarify biosynthesis vivo, will assist scientists elucidating accumulation discovering how engineer various means chemosynthesis, biosynthesis, chemoenzymatic synthesis. Finally, explore current challenges field recommend development strategy bile-acid-based drugs sustainable acids. The presented suggest novel managing can be artificially synthesized way.

Language: Английский

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Microbiome dysbiosis in patients with chronic endometritis and Clostridium tyrobutyricum ameliorates chronic endometritis in mice

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 30, 2024

Abstract Chronic endometritis is associated with the imbalance of female reproductive tract microbiota and pathogenic microbial infection. This study aimed to identify specific changes in endometrial microbiome patients explore how Clostridium tyrobutyricum ( C.t ) influences progression mice for further elucidating pathogenesis. For this purpose, tissues from 100 participants were collected divided into positive, weakly negative groups based on CD138 levels, while differences detected analyzed using 16S rRNA gene sequencing. Staphylococcus aureus S. )-induced mouse model was established, followed by treatment , inflammatory response, epithelial barrier, TLR4/NF-κB pathway evaluated. Results showed that α- β-diversity significantly lower positive group compared or groups, where had more unique operational taxonomic units. The abundance Proteobacteria found be increased, Actinobacteria Firmicutes, Bacteroidetes reduced group, area under curve value 0.664. Furthermore, resulted alleviation -induced barrier damage, activation mice. Clinical samples analysis revealed diversity altered having mechanistic investigations alleviated inactivating pathway. findings are envisaged provide a diagnostic therapeutic potential endometritis.

Language: Английский

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