Oropouche Virus (OROV) in Pregnancy: An Emerging Cause of Placental and Fetal Infection Associated with Stillbirth and Microcephaly following Vertical Transmission

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1435 - 1435

Published: Sept. 9, 2024

Oropouche virus (OROV) is an emerging arbovirus endemic in Latin America and the Caribbean that causes fever, a febrile illness clinically resembles some other arboviral infections. It currently spreading through Brazil surrounding countries, where, from 1 January to August 2024, more than 8000 cases have been identified Bolivia, Brazil, Columbia, Peru for first time Cuba. Travelers with fever United States Europe. A significant occurrence during this epidemic has report of pregnant women infected OROV who had miscarriages stillborn fetuses placental, umbilical blood fetal somatic organ samples were RT-PCR positive negative arboviruses. In addition, there four newborn infants having microcephaly, which cerebrospinal fluid tested IgM antibodies This communication examines biology, epidemiology, clinical features OROV, summarizes 2023–2024 epidemic, describes reported vertical transmission congenital infection, death, microcephaly addresses experimental animal infections potential placental pathology findings reviews bunyavirus agents can cause transmission. Recommendations are made travelling regions affected by epidemic.

Language: Английский

---

A potential mechanism of transplacental transmission of Oropouche virus in pregnancy

The Lancet Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 101083 - 101083

Published: Feb. 1, 2025

Language: Английский

---

Clinical course and management of COVID-19 in the era of widespread population immunity

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(2), P. 75 - 88

Published: Dec. 19, 2023

Language: Английский

---

Mpox (Monkeypox) in Pregnancy: Viral Clade Differences and Their Associations with Varying Obstetrical and Fetal Outcomes

Viruses, Journal Year: 2023, Volume and Issue: 15(8), P. 1649 - 1649

Published: July 28, 2023

In African countries where mpox (monkeypox) is endemic, infection caused by two genetically related clades—Clade I (formerly Congo Basin), and Clade IIa West Africa), both of which are potentially life-threatening infections. Prior to the 2022–2023 global outbreak, infections among pregnant women were reported have a 75% perinatal case fatality rate in Democratic Republic Congo, including only documented placental stillbirth from Congenital Mpox Syndrome, was associated with stillbirths Nigeria. The distinct strain, IIb, has focused attention on effects fetal outcomes. There been at least 58 cases occurring during outbreak. No confirmed adverse outcome, stillbirth, reported. absence morbidity mortality IIb corresponds overall non-pregnant <0.1%, as this clade demonstrated produce less-severe disease than or variants. Thus, there apparently important differences between clades affecting

Language: Английский

---

Mpox Virus in Pregnancy, the Placenta, and Newborn

Archives of Pathology & Laboratory Medicine, Journal Year: 2023, Volume and Issue: 147(7), P. 746 - 757

Published: March 1, 2023

Context.— Before its eradication, the smallpox virus was a significant cause of poor obstetric outcomes, including maternal and fetal morbidity mortality. The mpox (monkeypox) is now most pathogenic member Orthopoxvirus genus infecting humans. 2022 global outbreak has focused attention on potential effects during pregnancy. Objective.— To understand comparative different poxvirus infections pregnancy, virus, variola vaccinia cowpox virus. impact pregnant individual, fetus, placenta will be examined, with particular to occurrence intrauterine vertical transmission congenital infection. Data Sources.— data are obtained from authors' cases various published sources, early historical information contemporary publications. Conclusions.— Smallpox caused perinatal death, numerous reported transmission. In endemic African countries, also affected individuals, up 75% case fatality rate. Since start outbreak, increasing numbers women have been infected A detailed description given syndrome in stillborn resulting maternal-fetal placental infection, mechanisms infection discussed. Other poxviruses, notably and, 1 case, can Based evidence infections, remains threat population, it expected that additional occur future.

Language: Английский

---

Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned

Pediatric Research, Journal Year: 2024, Volume and Issue: 96(1), P. 64 - 72

Published: March 20, 2024

Language: Английский

---

Mapping cell-to-tissue graphs across human placenta histology whole slide images using deep learning with HAPPY

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 28, 2024

Abstract Accurate placenta pathology assessment is essential for managing maternal and newborn health, but the placenta’s heterogeneity temporal variability pose challenges histology analysis. To address this issue, we developed ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method quantifying of cells micro-anatomical tissue structures across whole slide images. HAPPY differs from patch-based features or segmentation approaches by following an interpretable biological hierarchy, representing cellular communities within tissues at single-cell resolution We present set quantitative metrics healthy term placentas as baseline future assessments health show how these deviate in with clinically significant placental infarction. HAPPY’s cell predictions closely replicate those independent clinical experts biology literature.

Language: Английский

---

Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures

Clinical & Translational Immunology, Journal Year: 2024, Volume and Issue: 13(2)

Published: Jan. 1, 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as 'preeclampsia-like syndrome'. However, the mechanisms underpinning SARS-CoV-2-induced malfunction are still unclear. Here, we investigated whether transcriptional architecture placenta altered response SARS-CoV-2 infection.

Language: Английский

---

The effects of COVID-19 on placental morphology

Placenta, Journal Year: 2023, Volume and Issue: 138, P. 88 - 96

Published: May 17, 2023

Language: Английский

---

Systematic review and synthesis of stillbirths and late miscarriages following SARS-CoV-2 infections

American Journal of Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 229(2), P. 118 - 128

Published: Jan. 25, 2023

Language: Английский

---