Journal of Gynecology Obstetrics and Human Reproduction, Journal Year: 2025, Volume and Issue: unknown, P. 102931 - 102931
Published: Feb. 1, 2025
Language: Английский
Journal of Gynecology Obstetrics and Human Reproduction, Journal Year: 2025, Volume and Issue: unknown, P. 102931 - 102931
Published: Feb. 1, 2025
Language: Английский
Placenta, Journal Year: 2024, Volume and Issue: 149, P. 64 - 71
Published: March 14, 2024
1.
Citations
3European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(1)
Published: Jan. 1, 2025
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in the placenta can lead to fetal distress and demise, characterized by severe trophoblast necrosis, chronic histiocytic intervillositis (CHI), massive perivillous fibrin deposition. We aimed uncover spatial immune‐related protein changes SARS‐CoV‐2 placentitis compared with CHI placentas uncomplicated pregnancies gain insight into underlying pathophysiological mechanisms. Placentas were retrospectively collected from cases resulting distress/demise ( n = 9), term controls 9). The expression of 53 proteins was quantified using GeoMx Digital Spatial Profiler three separate compartments: villi (fetal compartment), intervillous space, decidua (both maternal compartments). Compared controls, both displayed differentially expressed space only, including upregulation myeloid markers (e.g., CD40, CD11c, CD68, CD163). Specifically, associated reduced multiple apoptotic BAD, BIM, BLXL, BCL6). In conclusion, are enhanced cell infiltration but not villi. more prominently apoptosis‐related may an exaggerated immune response, causing placental dysfunction demise.
Language: Английский
Citations
0Annales de Pathologie, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Citations
0Journal of Speech Language and Hearing Research, Journal Year: 2025, Volume and Issue: 68(3), P. 1311 - 1332
Published: Feb. 21, 2025
This umbrella review synthesizes and discusses systematic reviews (SRs) meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults infants while summarizing vaccine-related literature search followed the Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, no restrictions population age or symptom severity. Four electronic databases were searched from their inception to October 2024. The Assessment Multiple 2 checklist Risk Bias tool used assess quality risk bias. identified 534 articles, narrowed down 14 SRs following full-text review: Nine focused COVID-19; two, born mothers infected during pregnancy; three, effects vaccination. A random-effects model revealed significantly high pooled estimates hearing loss (5.0%, 95% CI [1.0, 9.0], p < .012, three MAs, N = 21,932) tinnitus (13.5%, [5.9, 21.1], ≤ .001, four 36,236) adults. However, current nonhospitalized patients indicates that symptoms often improve after recovery. Studies also show low rate whose contracted pregnancy. Similarly, whereas has been linked tinnitus, these are rare, most experience improvement within weeks months. Evidence suggests adults, although remain rare newborns caution warranted due limitations variability studies.
Language: Английский
Citations
0Journal of Gynecology Obstetrics and Human Reproduction, Journal Year: 2025, Volume and Issue: unknown, P. 102931 - 102931
Published: Feb. 1, 2025
Language: Английский
Citations
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