To be or not to be manipulated by our bacteria? DOI Creative Commons
Marc Le Borgne, Marc Le Borgne,

Kézia Sossou-Echavidre

et al.

Published: Dec. 23, 2024

The gut microbiota has become a central focus of research since its intricate connection with the brain was identified. Notably, can influence mental health, opening new prospects for improving management psychiatric disorders. Understanding bidirectional interactions between brain, gut, and microbiome is crucial evaluating true impact on health subsequent implications psychiatry. Currently, brain-gut-microbiome axis communicates through five interconnected pathways: immune system, vagus nerve, enteric nervous neuroendocrine circulatory system. development microbiota-based therapeutics signals significant changes in current clinical practices. Furthermore, microbiome-based are expected to undergo substantial regulatory transformations Europe coming years. This mini-review aims explore these aspects evaluate potential bacteria shape interventions.

Language: Английский

Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation DOI
Sarvesh Sabarathinam

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 241, P. 173805 - 173805

Published: June 5, 2024

Language: Английский

Citations

5
Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis DOI Creative Commons

Tingting Luo,

Qingya Che,

Ziyi Guo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

Citations

4
Exploring the Role of Gut Microbiota in Depression: Pathogenesis and Therapeutic Insights DOI Creative Commons
Jiale Zhang, Jingsong He, Jieqiong Hu

et al.

Asian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 105, P. 104411 - 104411

Published: Feb. 21, 2025

Language: Английский

Citations

0
Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa DOI Creative Commons
Benjamin Thomas, Nadia Andrea Andreani, Emilie Lahaye

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 8 - 16

Published: Feb. 22, 2025

Language: Английский

Citations

0
Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD–MCI mice DOI Creative Commons

Tayier Tuersong,

Qian Wu, Yan Chen

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156729 - 156729

Published: April 12, 2025

Anacyclus pyrethrum (l.) DC has potential value in treating Parkinson's disease (PD)-mild cognitive impairment (MCI), manifesting as impaired memory, attention, executive function, and language. However, the specific targets modes of action A. remain unclear. The aim this study was to identify active components examine their effectiveness a mouse model PD-MCI. We generated ethanol extracts root (EEAP) identified its related using UHPLC-MS/MS network pharmacology.The PD-MCI induced via intraperitoneal administration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP). After following continuous EEAP,Altered learning or well anxiety, were tested morris water maze, eight-arm radial arm maze (RAM), open-field test,elevated plus-maze. Brain histopathology ultrastructural changes examined brightfield microscopy, electron respectively. Furthermore, protein expression assessed western blotting.Stool samples used for metabolomics analysis by 16S rDNA sequencing determine compositional gut microbiota.We conducted short-chain fatty acid targeted experiment role gut-brain axis Using UPLC-MS-MS, 126 compounds from samples.After searching databases literature reports, 31 544 drug-disease screened. Biological processes molecular functions, such energy channels, cell signaling, metabolism, discovered through GO analysis. showed that average swimming distance escape latency mice EEAP groups decreased. had much higher number errors working memory than control mice. In open field experiment, compared with group, group exhibited an increase movement speed total distance, along decrease residence time.In elevated plus less anxiety Model. Donepezil/Levodopa(D/l) mitigated anxiety-like behavior, (100-400 mg/kg) dose-dependent open-arm metrics, suggesting it may ease mice.Hippocampal tissue treated different doses intact cellular layers hematoxylin-eosin-stained cones slightly better;cells arranged neatly; morphology normal, distributed uniformly. Electron microscopy revealed nuclear membrane, chromatin, nucleoli clearly demarcated hippocampus EEAP, contrary group. brain lighter thinner bands amyloid precursor (APP) Aβ observed those mice, APP blank shown stronger bands. EEAP-treated weaker, indicating reduced expression. lower Bcl-2 Bax levels. treatment increased decreased expression.Compared substantially low glutathione peroxidase (GSH-Px),superoxide dismutase(SOD),catalase (CAT)activity (p < 0.05),much 0.05) EEAP-H model. intervention significantly modulated fecal metabolic profile abundance steroid lipid metabolites, including linoleylethanolamine, markedly altered reversing several these abnormalities. PLS-DA OPLS-DA significant separation between (Q2= 0.542, p 0.01), confirming effect. Random forest 15 key markers, d-glutamine hydrocodone. Metabolic pathway demonstrated enrichment phenylalanine, tyrosine, tryptophan arginine biosynthesis pathways 0.05). Support Vector Machine (SVM) achieved AUC approaching 1, substantial differences metabolite profiles. influenced composition functional intestinal microbiota. Venn diagram illustrates each shared 342 operational taxonomic units (OTUs), 400 exhibiting distinct Bacteroidetes proportion. LEfSe g_Prevotella characteristic bacterium c_Epsilonproteobacteria g_Adlercreutzia 100 Faith's Phylogenetic Diversity (PD) index highest Non-metric Multidimensional Scaling (NMDS)/Principal Coordinates Analysis (PCoA) microbial community structure. Short-chain acids (SCFAs) indicated acetic predominant metabolite, while dose-dependently regulated propionic isovaleric levels (VIP > 0.001). These findings demonstrate exerts regulatory effects reshaping structure functions holds great promise therapeutic agent PD-MCI, exerting multiple mechanisms, regulating expression, modulating profile, microbiota metabolites.

Language: Английский

Citations

0
Potential causal association between the oral microbiome and bipolar disorder DOI
Jing Li, Jun Chen, Jiwen Li

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine DOI Creative Commons
Asiya Nazir,

Fathima Hasnain Nadeem Hussain,

Afsheen Raza

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 4, 2024

Over recent years, studies on microbiota research and synthetic biology have explored novel approaches microbial manipulation for therapeutic purposes. However, fragmented information is available this aspect with key insights scattered across various disciplines such as molecular biology, genetics, bioengineering, medicine. This review aims to the transformative potential of in advancing microbiome therapies, significant implications healthcare, agriculture, environmental sustainability. By merging computer science, engineering, allows precise design modification biological systems via cutting edge technologies like CRISPR/Cas9 gene editing, metabolic oligonucleotide synthesis, thus paving way targeted treatments personalized probiotics engineered microorganisms. The will also highlight vital role gut disorders caused by its dysbiosis suggesting microbiota-based therapies innovations biosensors real-time health monitoring, non-invasive diagnostic tools, automated bio foundries better outcomes. Moreover, challenges including genetic stability, safety, robust regulatory frameworks be discussed understand importance ongoing ensure safe effective interventions.

Language: Английский

Citations

3
Comparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia DOI Creative Commons
Lucero Nuncio-Mora, Humberto Nicolini, Nuria Lanzagorta

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 2071 - 2071

Published: Oct. 16, 2024

Studies of the composition gut microbiome have consistently shown that psychiatric disorders such as schizophrenia are associated with dysbiosis. However, research focusing on adolescents early-onset psychosis remains limited. This study aimed to characterize microbial communities and their potential metabolic functions in these populations. We identified genera

Language: Английский

Citations

1
Effects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial DOI Open Access
Alisa Turbić, Liesbeth Vandenput, Anoohya Gandham

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4219 - 4219

Published: Dec. 6, 2024

Correction of decreased diversity the gut microbiome, which is characteristic menopause, by supplementation with a synbiotic may attenuate or prevent dysbiosis processes and preserve bone mass. We describe rationale design OsteoPreP trial aimed at evaluating effects 12 months on metabolic health in postmenopausal Caucasian women.

Language: Английский

Citations

0
To be or not to be manipulated by our bacteria? DOI Creative Commons
Marc Le Borgne, Marc Le Borgne,

Kézia Sossou-Echavidre

et al.

Published: Dec. 23, 2024

The gut microbiota has become a central focus of research since its intricate connection with the brain was identified. Notably, can influence mental health, opening new prospects for improving management psychiatric disorders. Understanding bidirectional interactions between brain, gut, and microbiome is crucial evaluating true impact on health subsequent implications psychiatry. Currently, brain-gut-microbiome axis communicates through five interconnected pathways: immune system, vagus nerve, enteric nervous neuroendocrine circulatory system. development microbiota-based therapeutics signals significant changes in current clinical practices. Furthermore, microbiome-based are expected to undergo substantial regulatory transformations Europe coming years. This mini-review aims explore these aspects evaluate potential bacteria shape interventions.

Language: Английский

Citations

0