Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood DOI Creative Commons

Carles Colom-Rocha,

Cristian Bis‐Humbert, M. Julia García‐Fuster

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 27, 2024

Background Few studies have previously evaluated the long-term impact of initiating combined use alcohol and cocaine early-in-life during adolescence. Our preclinical study characterized changes in affective-like behavior and/or voluntary ethanol consumption emerging later on adulthood induced by a prior adolescent drug exposure, as well tested therapeutical interventions (i.e., cannabidiol or ketamine) to prevent observed effects. Methods We performed three independent with male female Sprague-Dawley rats, treated adolescence (postnatal days, PND 29–38) non-contingent paradigms ethanol, cocaine, their combination vehicle. Later on, adult rats were (1) scored for state (forced-swim, elevated-plus maze, novelty-suppressed feeding, sucrose preference), (2) allowed freely drink 6 weeks (two-bottle choice), (3) ketamine before given access adulthood. Results No signs increased negative affect following treatments. However, exposure was risk-factor developing an adulthood, both rats. This risk similar when since alone showed no effects intake. Finally, exposed pretreated (and/or ketamine, but just females) reduced consumption. Conclusion data provided two options capable preventing early initiation decreasing

Language: Английский

Animal models of compulsion alcohol drinking: Why we love quinine-resistant intake and what we learned from it DOI Creative Commons
Thatiane De Oliveira Sergio, Raizel M. Frasier, F. Woodward Hopf

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting ~$250 billion/year in US alone and producing myriad medical social harms. Also, number of deaths related to problem drinking has been increasing dramatically. Compulsive alcohol drinking, characterized by intake that persists despite negative consequences, can be particularly important a major obstacle treatment. With people suffering from AUD during past years, there is critical need understand neurobiology compulsive drives for alcohol, as well development novel pharmacological therapies. Here we discuss rodent compulsion-like (CLAD) models, focusing on two widely used adverse stimuli model responding, quinine adulteration footshook-resistant intake. For both cases, goal uncover behavior patterns brain circuits underlie drive even face consequences. We caveats, benefits, potential mechanisms, models consequence-resistant responding more generally, especially highlight some advantages quinine-resistance over footshook-resistance. Further, since this review contributes Special issue focused Molecular Aspects Drug Use, our new findings showing how noradrenergic system CLAD responding. In particular, comment importance α1 β adrenergic receptors (ARs) targets treating AUD.

Language: Английский

Citations

20
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice DOI Creative Commons

Jean K. Rivera-Irizarry,

Lia J. Zallar, Olivia B. Levine

et al.

Biology of Sex Differences, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 13, 2023

Binge alcohol drinking is a risk factor linked to numerous disease states including use disorder (AUD). While men binge drink more than women, this demographic gap quickly shrinking, and preclinical studies demonstrate that females consistently consume males. Further, women are at increased for the co-expression of AUD with neuropsychiatric diseases such as anxiety mood disorders. However, little understood about chronic voluntary its long-term effects on behavior. Here, we sought characterize sex differences in protracted abstinence anxiety- affective-related behaviors males females.

Language: Английский

Citations

20
Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain DOI Creative Commons
Vittoria Borgonetti, Amanda J. Roberts, Michal Bajo

et al.

British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 180(18), P. 2377 - 2392

Published: April 13, 2023

Abstract Background and Purpose Chronic pain is considered a key factor contributing to alcohol use disorder (AUD). The mechanisms responsible for chronic associated with consumption are unknown. We evaluated the development of in mouse model dependence investigate role neuroinflammation. Experimental Approach chronic‐intermittent ethanol two‐bottle choice CIE‐2BC paradigm generates three groups: alcohol‐dependent escalating intake, nondependent (moderate drinking) alcohol‐naïve control male female mice. measured mechanical allodynia during withdrawal after last voluntary drinking. Immunoblotting was used evaluate protein levels IBA‐1, CSFR, IL‐6, p38 ERK2/1 spinal cord tissue dependent non‐dependent animals. Key Results found significant escalation drinking group compared group. developed 72 h withdrawal, which completely reversed observed an increased hypersensitivity naïve 50% Increased IBA‐1 CSFR expression both hypersensitivity‐abstinence related neuropathy‐alcohol mice, IL‐6 ERK1/2 activation mice hypersensitivity‐related abstinence, but not alcohol‐evoked neuropathic pain. Conclusions Implications induces two distinct conditions specific type exposure: abstinence‐related about half

Language: Английский

Citations

18
The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females DOI Creative Commons

Megan Castle,

Meghan E. Flanigan

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100618 - 100618

Published: Feb. 20, 2024

Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide, but current treatments are insufficient in fully addressing the symptoms that often lead to relapses alcohol consumption. The brain's serotonin system has been implicated AUD for decades major regulator stress-related behaviors associated with increased This review will discuss literature on association between neurobiological adaptations systems humans as well effectiveness receptor manipulations alcohol-related like consumption withdrawal. We further how these findings relate animal models, including comparison systemic pharmacological modulating next provide detailed overview brain region-specific roles signaling preclinical highlighting complexity forming cohesive model function providing possible avenues more effective therapeutic intervention. Throughout review, we what known about sex differences sequelae role sequelae. stress critical need additional studies women female animals so may build clearer path elucidating sex-specific serotonergic mechanisms develop better treatments.

Language: Английский

Citations

6
Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons DOI Creative Commons
Shannon M. Thompson,

Carly B. Fabian,

Anthony S. Ferranti

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 238, P. 109638 - 109638

Published: July 22, 2023

Language: Английский

Citations

11
Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion DOI

Amanda L Salazar,

Samuel W. Centanni

Alcohol, Journal Year: 2024, Volume and Issue: 121, P. 45 - 57

Published: July 23, 2024

Language: Английский

Citations

4
KCa2 channel positive modulation reduces alcohol drinking in female C57BL/6J mice DOI

Kerstin Lindquist,

Audrey E. Padula,

Natalie S Katzenmeyer

et al.

Alcohol, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review DOI Creative Commons

Garrett Winkler,

Nicholas J. Grahame

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Alcohol use disorder (AUD) and major depressive (MDD) are often comorbid, it is estimated that between 15 % to 33% of people dependent on alcohol have an MDD diagnosis. Mood-related symptoms also common in humans during acute withdrawal, but by most accounts, abate after 2-4 weeks abstinence. Preclinical studies, important for understanding the etiology finding treatments this comorbidity, find depression-like anxiety-like phenotypes early abstinence along with protracted negative affect detectable past 2 postcessation. In narrative review, we focus translational divergence AUD comorbidity a time line mismatch species concurrent + following AUD. We highlight preclinical success clinical failure classic antidepressants relative absence withdrawal high-drinking selected lines mice rats. suggest sources these discrepancies, including discussion relief/reward-driven drinking subpopulations future directions field.

Language: Английский

Citations

0
Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system DOI Creative Commons
Harold L. Haun,

RAUL HERNANDEZ,

Luzi Yan

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115482 - 115482

Published: March 29, 2025

Language: Английский

Citations

0
Stress and gonadal steroid influences on alcohol drinking and withdrawal, with focus on animal models in females DOI Creative Commons

Deborah A. Finn

Frontiers in Neuroendocrinology, Journal Year: 2023, Volume and Issue: 71, P. 101094 - 101094

Published: Aug. 7, 2023

Language: Английский

Citations

10