Vortioxetine’s Therapeutic Potential: Cardiac Responses to Chronic Unpredictable Mild Stress in a Rat Model

Arquivos Brasileiros de Cardiologia, Journal Year: 2025, Volume and Issue: 122(2)

Published: Jan. 1, 2025

Abstract Background Stress arises in response to threats or challenges, affecting both physical and mental health. While its harmful effects on the heart are widely recognized, cellular-level investigations remain limited. Antidepressants, including vortioxetine (VOR), known impact cardiovascular system. VOR, used treat major depressive disorder, is considered a promising option for patients with disease due anti-inflammatory antioxidant properties, which may reduce cardiac damage. Objectives This study aimed assess of chronic unpredictable mild stress (CUMS) rat hearts evaluate VOR’s potential protective against stress-induced Methods Twenty-eight male Wistar Albino rats were divided into four groups. The CUMS group experienced random daily 6 weeks, while CUMS+VOR received VOR treatment alongside stress. control groups not exposed Heart samples examined histopathologically immunohistochemically. Results showed increased hyperemia, hemorrhage, edema, vacuolar degeneration, mononuclear cell infiltrations, reduced troponin IL-10 caspase-3 NF-κB expressions compared (p≤0.001). improved these findings, normalizing histopathological immunohistochemical results. Conclusions caused significant damage rats, by alleviating pathological changes.

Language: Английский

---

Impact of Chronic Psychological Stress on Cardiovascular Disease Risk: A Narrative Review

Heart and Mind, Journal Year: 2024, Volume and Issue: 8(4), P. 268 - 278

Published: Sept. 26, 2024

Cardiovascular disease (CVD) remains a leading cause of death worldwide, and identification its risk factors is pivotal in ensuring lower socioeconomic burden on society. Psychological stress shows strong causal link with CVD through the interaction physiological behavioral factors. Importantly, there an association between duration level propensity for CVD. Chronic exerts effects release glucocorticoids (GCs) such as cortisol, which subsequently promote proinflammatory effects, exacerbating atherosclerotic plaque development. Stress also exacerbates secretion cardiokines tumor necrosis factor-alpha (TNF-α). Elevated TNF-α associated endothelial dysfunction angiogenesis-mediated progression, increased extended. Stress-induced GC inhibits glucose uptake to hyperglycemia consequent hyperinsulinemia. This increases individual’s susceptibility another factor, type 2 diabetes mellitus (T2DM). These are further exacerbated by impact chronic behavior eating habits. Increased consumption comfort foods, typically containing high fat sugar contents, directly body mass index low-density lipoprotein (LDL) cholesterol, both well-known drivers atherosclerosis. Moreover, often results reductions physical activity, particularly individuals at low baseline levels activity. obesity, T2DM, LDL-cholesterol levels, all development review outlines key research findings relating role psychological plays altering

Language: Английский

---

Relationships between disease severity, psychological stress, and health-related quality of life among patients with acute coronary syndrome: mediation of illness perception

European Journal of Cardiovascular Nursing, Journal Year: 2024, Volume and Issue: 23(6), P. 652 - 660

Published: Feb. 29, 2024

Abstract Aims Patients with acute coronary syndrome (ACS) often experience reduced health-related quality of life (HRQOL), which may be attributable to the disease severity and psychological stress. While illness perception is speculated a potential pathway underlying these relationships, evidence supporting this mechanism remains limited. This study aimed investigate relationships between severity, stress, HRQOL whether are mediated by in patients ACS. Methods results Data were collected from June July 2019 September 2020 cardiology departments four public hospitals China. Eligible completed measures perception, HRQOL, socio-demographic clinical characteristics. analysed employing hierarchical multiple regression structural equation modelling. included 405 participants (mean age 60.63 years, 67.4% male). After controlling for covariates, higher levels (β = 0.115, P 0.024) stress −0.209, P＜0.001) associated poorer HRQOL; however, became non-significant after adding into model. Structural modelling analysis suggested that played mediating role accounting 45.95% 65.79% total effects, respectively. Conclusion found among Improving patients’ should consider its important influencing factors focus on promoting positive perception.

Language: Английский

---

Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(1), P. 281 - 303

Published: July 8, 2023

Language: Английский

---

Analysis of the characteristics and illness comprehension bias among Chinese patients with psycho-cardiovascular disease: a multi-centre cross-sectional survey

Journal of Global Health, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

Abstract Background Psychological distress, such as depression and anxiety, impacts cardiovascular disease (CVD) prognosis management. Illness comprehension is essential for effective treatment, but biases can lead to suboptimal outcomes. We explored psycho-cardiovascular (PCD) patient characteristics, with a specific focus on treatment choices from patients' perspectives in China, improve management strategies. Methods enrolled 864 PCD patients Chinese hospitals across 11 provinces. Tools included the seven-item General Anxiety Disorder scale, nine-item Patient Health Questionnaire, self-designed illness comprehensibility survey. used χ2 test, univariate, multivariate logistic regression examine characteristics. Results Of 834 patients, over 90% experienced mild moderate anxiety depression, yet less than 10% received treatment. 52.90% of had high comprehension. Among group, there were fewer labourers (19.30% vs. 26.40%; P < 0.05), older individuals (39.20% 46.90%; those lower household income (15.60% 30.50%; 0.05). A greater proportion group lacked insurance (17.50% 10.00%; they more highly educated (42.90% 32.10% college education). Additionally, frequently psychological consultation (24.00% 5.10%; 0.05) therapy (7.70% 2.30%; These groups preferred tertiary (71.66% 63.33%; clinics (40.14% 25.90%; In comparison, low prioritised cost (32.65% 46.41%; favoured transition community (16.55% 25.38%; Conclusions More CVD departments experience rates. Different levels are associated variations willingness, considerations, health care preferences, medication choices, knowledge acquisition methods.

Language: Английский

---

Ferulic acid protects against stress-induced myocardial injury in mice

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 498, P. 117309 - 117309

Published: March 20, 2025

Language: Английский

---

An Assessment of Stress and Coping Strategies Among Pharmacy Students of Knust and its Relation to Academic Performances

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Background: Pharmacy students often experience varying stress levels due to the demanding nature of their academic program. Understanding relationship between stress, coping mechanisms, and performance is important support student well-being success. Several key sources for pharmacy have been identified, including demands such as exams maintaining high grades, financial concerns, time management issues, personal factors homesickness. Pharmacy use a variety strategies, both adaptive (such management, exercise, social support) maladaptive emotional eating substance use) methods. The year study was found contribute perceived levels. Methods: This cross-sectional conducted among undergraduate at KNUST. Informed consent objectives were outlined every participant before they took part in study. To maintain anonymity, names excluded. questionnaire adapted 10-item Perceived Stress Scale (PSS-10) developed by Cohen colleagues, Brief COPE scale, other literature sources. These used measure degree causing effect on performance, different strategies manage stress. Results: Majority (55 %) regularly during training. causes ranged from academic, social, financial. most frequent academic-related, which included workload assignments, tests, be highest level 600 then 200 400. Financial-related second contributor students. Most combination alcohol drugs, meditation, sleep, regular meetings interactions with friends Conclusion: A Significant number of pharmacy KNUST mainly related workloads, challenges. cope these stressors, adapt adequate consumption or substances, watching movies, interaction friends. It essential implement effective psychological programs, prevention programs that cater needs students, aiming enhance psychosocial well-being. Further research should explore connection well students' overall quality life.

Language: Английский

---

The Omega-3 Index in Military Personnel: A Systematic Review

Military Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Introduction Long-chain n-3 polyunsaturated fatty acids (LC PUFA), primarily eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), have received considerable interest from the scientific community as a dietary strategy to enhance physical performance, recovery, neuroprotection in addition well-established role of supporting cardiovascular health. Given that military personnel are routinely subjected psychologically physiologically (e.g., cardiovascular, musculoskeletal) stressful environments, LC PUFA intake may represent simple, yet meaningful, nutritional intervention support Warfighter health fitness. Dietary EPA + DHA, via fish or supplement, can be reliably tracked using omega-3 index (O3i), which is relative amount DHA red blood cells (RBC) expressed percentage total acids. The purpose this systematic review was establish baseline O3i status active duty with intent providing actionable evidence-based nutrition recommendations. Materials Methods Three databases (PubMed, Google Scholar, Omega-3 Clinical Study Database) were searched systematically. A 645 articles screened, 11 studies (13 observations) eligible for inclusion. Non-RBC plasma) converted validated equations. Data reported pooled mean analyzed based on service type Army, Air Force). Results Based composed 3,615 personnel, average 3.18% (95% CI: 3.15, 3.21) ranged 2.47% 4.62%. Most observations an &lt;4% (76.9%). Army (combined), U.S. only, Special Forces had &lt;4%, whereas Austrian Force between 4% 5%. Conclusions Military without exception, exhibit suboptimal O3i. Achieving optimal low cost, modifiable risk factor used conjunction traditional medicine appropriate training mission performance personnel. what we know about PUFAs present it paramount Defense organizations acknowledge evidence implement policies strategies promote change. CLINICAL TRIAL REGISTRATION None, but registration (PROSPERO): CRD42023410361

Language: Английский

---

Insights Into Heart-Tumor Interactions in Heart Failure

Circulation Research, Journal Year: 2025, Volume and Issue: 136(11), P. 1262 - 1285

Published: May 22, 2025

Heart failure (HF) often coexists with cancer. Beyond the known cardiotoxicity of some cancer treatments, HF itself has been associated increased incidence. The 2 conditions share common risk factors, mechanisms, and interactions that can worsen patient outcomes. bidirectional relationship between presents a complex interplay factors are not fully understood. Recent preclinical evidence suggests may promote tumor growth via release protumorigenic from injured heart, revealing as potentially condition. Our review discusses biological crosstalk cancer, emphasizing impact on growth, inflammation, modulating immune system central mechanisms. We further explore clinical implications this connection propose future research directions. Understanding mechanistic overlap could lead to new biomarkers therapies, addressing growing prevalence both enhancing approaches diagnosis, prevention, treatment.

Language: Английский

---

The Role of Pro-Opiomelanocortin Derivatives in the Development of Type 2 Diabetes-Associated Myocardial Infarction: Possible Links with Prediabetes

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 314 - 314

Published: Jan. 29, 2024

Myocardial infarction is a major contributor to CVD-related mortality. T2DM risk factor for MI. Stress activates the HPA axis, SNS, and endogenous OPS. These POMC derivatives increase blood glucose cardiovascular response by inhibiting PI3K/AkT insulin signaling pathway increasing cardiac contraction. Opioids regulate effect of axis SNS they are cardioprotective. The chronic activation stress may lead resistance, dysfunction, T2DM, therefore, preceded prediabetes. Studies have shown that prediabetes associated with an increased MI because inflammation, hyperlipidemia, endothelial hypertension. reported be dysregulated in However, OPS not been explored during on has yet fully understood. impact needs investigated. This study sought review potential pathways could

Language: Английский

---