Sex differences in heart rate and heart rate variability responses to transcutaneous auricular vagal nerve stimulation in rats DOI Creative Commons
Margherita Barbetti, Cristina Ottaviani, Julian F. Thayer

et al.

Autonomic Neuroscience, Journal Year: 2024, Volume and Issue: 257, P. 103237 - 103237

Published: Dec. 13, 2024

Language: Английский

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease DOI Open Access

Abigail G. White,

Elias Elias,

Andrea Orozco

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5085 - 5085

Published: May 7, 2024

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, molecular responses. In humans, chronic manifests as an enduring consistent feeling pressure being overwhelmed for extended duration. This can result in a persistent proinflammatory response peripheral nervous system (CNS), resulting cellular, behavioral effects. Compounding stressors may increase risk chronic-stress-induced inflammation, which yield serious health consequences, including mental disorders. review summarizes current knowledge surrounding neuroinflammatory rodent models stress—a relationship continually defined. Many studies investigating effects on neuroinflammation have identified significant changes inflammatory modulators, nuclear factor-κB (NF-κB) toll-like receptors (TLRs), cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6. suggests these are key factors response, contribute establishment anxiety depression-like symptoms. neurological modulating through gene knockdown (KD) knockout (KO), conventional alternative medicine approaches, discussed.

Language: Английский

Citations

12
Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review DOI Creative Commons

Ningyi Zou,

Qing Zhou,

Yuzhengheng Zhang

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Currently, clinical practice and scientific research mostly revolve around a single disease or system, but the disease-oriented diagnostic therapeutic paradigm needs to be revised. This review describes how transcutaneous auricular vagus nerve stimulation (taVNS), novel non-invasive neuromodulation approach, connects central peripheral systems of body. Through widely distributed from head abdominal cavity, this therapy can improve treat system disorders, central-peripheral comorbidities caused by autonomic dysfunction. In past, on taVNS has focused treatment disorders modulating brain nerve. As innervates heart, lungs, liver, pancreas, gastrointestinal tract, spleen other organs, could have an overall modulatory effect region body where is widespread. Based physiological basis, authors summarize existing evidence ability regulate cardiac function, adiposity, glucose levels, immune among others, diseases, complex diseases with comorbidities. shows successful examples progress using mechanisms more perspectives, demonstrating expanded scope value provide new ideas approaches for holistic both perspectives.

Language: Английский

Citations

10
Stimulation of Auricular Vagus Nerve Ameliorates Chronic Stress induced Metabolic Syndrome via Activation of Sirtuin-6 DOI
Arjun Singh Kaushik, Vipul Agarwal, Neeraj Kumar

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151567 - 151567

Published: March 5, 2025

Language: Английский

Citations

1
Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis DOI
Rishabh Chaudhary, Ajay Prasad, Vipul Agarwal

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 125, P. 111046 - 111046

Published: Oct. 23, 2023

Language: Английский

Citations

13
Transcutaneous vagus nerve stimulation: a bibliometric study on current research hotspots and status DOI Creative Commons

Shiyu Fan,

Long Yan, Junfeng Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 16, 2024

Background Transcutaneous Vagal Nerve Stimulation (tVNS) has been used as a promising noninvasive neuromodulation technique for the treatment of various systems.The aim this study was to analyze research hotspots and future directions tVNS in 21st century by using bibliometric methods. Methods The object literature related from Web Science database 2000 May 2024. In order measure number issuance, institutions, authors, countries, keywords, co-citations, journals publication, we VOSviewer, Citespace, Bibliometrix R-package, Scimago Graphica software. A narrative review current content conducted gain better understanding state field. Results total 569 papers were included study. results show that 2024, publications shows an increasing trend year year, involving 326 institutions. United States, China, Germany are major centers. identified 399 which roughly formed 11 natural clusters, revealing mainly reflected 3 areas: intervention efficacy on nervous system diseases, mechanism action tVNS, stimulation mode tVNS. top 10 most cited references focus into Conclusion safety have confirmed previous studies, but standardized protocol not yet developed, clinical studies small sample sizes lack multicenter multidisciplinary collaboration. Currently, is neurological psychiatric cardiovascular some autoimmune diseases. It expected field will continue application central diseases exploration mechanisms, at same time, with rise non-invasive technology, other also great potential development.

Language: Английский

Citations

4
Vitamin D alleviates chronic stress-induced testicular steroidogenesis disruption in Wistar rats DOI
Siddhi Srivastava,

Sukriti Srivastava,

Vipul Agarwal

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102910 - 102910

Published: April 1, 2025

Language: Английский

Citations

0
Probiotics as a Treatment of Chronic Stress Associated Abnormalities DOI
Vipul Agarwal, Rishabh Chaudhary,

Anugya Gupta

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
Effects of multisession prefrontal cortex tDCS or taVNS on stress, perceived stress and sleep quality: a double-blind, randomized controlled study DOI Creative Commons

Laya Dalila Dos Reis,

Laura Pereira Generoso,

Gabrielly Santos Pereira

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Chronic stress is a condition characterized by prolonged stimulation, leading to mental and physical weakness. It can have detrimental effects on individuals' health cognitive function, potentially causing various issues. This article explores the potential of non-invasive neuromodulation techniques, specifically transcranial direct current stimulation (tDCS) transcutaneous auricular vagus nerve (taVNS), in managing chronic improving sleep quality.

Language: Английский

Citations

3
Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets DOI

Anugya Gupta,

Vipul Agarwal

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Language: Английский

Citations

2
Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models DOI
Rishabh Chaudhary,

Md Suhil Ibne Azam,

Bhavana Dowand

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Language: Английский

Citations

1