Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(7), P. 1686 - 1694

Published: April 25, 2024

Language: Английский

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A web-based questionnaire to evaluate risk factors to develop cow milk allergy

European Journal of Pediatrics, Journal Year: 2025, Volume and Issue: 184(4)

Published: March 14, 2025

Abstract Many environmental, genetic, and epigenetic variables are considered to influence the evolution of cow’s milk allergy (CMA). The gastro-intestinal microbiota may play a direct role in or inhibit tolerance development. In this study, we planned evaluate presence previously identified risk factors for composition. This study used cross-sectional electronic survey Turkiye, utilizing national convenience sample 270 children with CMA, as reported by their caregivers, 2154 healthy controls. We developed web-based questionnaire gather information on pregnancy maternal-related factors, delivery mode, feeding patterns, antibiotic use, pets home. affecting CMA were maternal age (OR 0.897; 0.862–0.934, p < 0.01), allergic disorders 3.070; 1.891–4.983, 0.001) both parents 3.831; 1.202–12.210, 0.001), weight at conception 1.016; 1.003–1.030, 0.05), gain during 1.033; 1.012–1.056, (absence a) pet home 1.394; 1.003–1.938, intrapartum use 1.469; 1.092–1.975, first 6 months life 1.933; 1.306–2.863, number householders 0.794; 0.650–0.969, 0.05). Conclusion : addition parents, pregnancy, found be microbiota-related CMA. Potential strategies related composition contribute positively disease’s development progression. What Is Known: • gut microbiome contributes cow allergy, disrupted maturation year appears common pediatric food allergies. Factors that an infant’s within 1000 days relationship between these enhance diagnosis, prevention, treatment. New: Besides parental disorders, six life,

Language: Английский

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Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

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Immune therapies in coeliac disease and food allergies: Advances, challenges, and opportunities

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101960 - 101960

Published: April 23, 2025

Coeliac disease and food allergy management primarily relies on the strict avoidance of dietary antigens. This approach is challenging to maintain in real-world settings carries risk life-threatening anaphylaxis. Despite their distinct pathogenesis, both disorders are driven by maladaptive responses proteins, creating opportunities for shared treatment strategies. In allergy, desensitisation therapies such as oral, sublingual, epicutaneous immunotherapy well-established, complemented biologics like omalizumab dupilumab. However, induction sustained tolerance remains challenging. contrast, therapeutic advancements coeliac still early stages. Current efforts focus gluten detoxification or modification, immune blockade modulation, tolerogenic approaches, barrier restoration. Emerging therapies, including JAK BTK inhibitors microbiome-targeted interventions, support further targeted options conditions. Biomarkers tracking gluten-specific T cells have emerged valuable tools immunomonitoring symptom assessment disease, although standardisation patient-reported outcome measures challenge protocols needed. Food trials reliant double-blind placebo-controlled challenges measure allergen reactivity, but these time-consuming, carry risks, underscore need surrogate biomarkers. The successful development immune-targeted will require building an toolset optimally assess systemic antigens Clinically, this could lead better outcomes patients who might otherwise remain undiagnosed untreated due absence significant enteropathy allergen-specific symptoms.

Language: Английский

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The Impact of Probiotic Supplementation on the Development of the Infant Gut Microbiota: An Exploratory Follow-Up of a Randomised Controlled Trial

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 984 - 984

Published: April 25, 2025

Early-life establishment of the gut microbiota plays a role in lifelong health, with disruptions linked to heightened risks metabolic and immune disorders. Probiotic supplementation may be used modulate infant microbiome promote favourable development. Here, we evaluate how Lab4B probiotic shapes development over first 6 months. Faecal samples collected from infants enrolled PROBAT (ISRCTN26287422), randomised, double-blind, placebo-controlled trial, were analysed using culture-dependent -independent (16S rDNA metagenomic shotgun sequencing) techniques examine composition, diversity, capabilities microbiome, as well abundance antimicrobial resistance genes (ARGs). encouraged distinct composition characterised by elevated abundances Bifidobacteriaceae weeks (p = 0.006) Lactobacillaceae throughout months < 0.05 at every 6-week time point), accelerated microbial diversification, reduced beta-lactam- cephalosporin-resistance genes, differences predicted start end points. Supplementation this neonatal population, which is high risk atopy, significantly influenced during

Language: Английский

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Atopic dermatitis and IgE-mediated food allergy

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(3), P. 262 - 277

Published: June 21, 2024

Language: Английский

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Pathogenic mechanisms in the evolution of food allergy

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Summary The early development of the neonatal immune system is profoundly influenced by exposure to dietary and microbial antigens, which shapes mucosal tolerance. Successful oral tolerance induction crucially dependent on microbially imprinted cells, most notably RORγt + regulatory T (Treg) antigen presenting cells essential for preventing food allergy (FA). FA can be envisioned result from disruptions at key checkpoints (CKPTs) that govern induction. These include gut epithelial sensory effector circuits when dysregulated promote pro‐allergic dysbiosis. They also are disrupted dysbiosis responses unleashed dysregulation aforementioned cascades. Understanding these developing therapeutic strategies restore homeostasis in FA.

Language: Английский

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Food Allergy, Nutrition, Psychology, and Health

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Management of atopic dermatitis with food allergy

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(3), P. 231 - 232

Published: Aug. 23, 2024

Language: Английский

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