Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103476 - 103476
Published: Dec. 19, 2024
Language: Английский
Toxicon, Journal Year: 2024, Volume and Issue: 248, P. 108038 - 108038
Published: July 22, 2024
Language: Английский
Citations
15
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116612 - 116612
Published: June 18, 2024
T-2 toxin is one of trichothecene mycotoxins, which can impair appetite and decrease food intake. However, the specific mechanisms for toxin-induced anorexia are not fully clarified. Multiple research results had shown that gut microbiota have a significant effect on regulation. Hence, this study purposed to explore potential interactions regulate factors in induced by toxin. The divided mice into control group (CG, 0 mg/kg BW toxin) toxin-treated (TG, 1 toxin), oral gavage 4 weeks, construct subacute poisoning mouse model. This data proved was able induce an increased contents gastrointestinal hormones (CCK, GIP, GLP-1 PYY), neurotransmitters (5-HT SP), as well pro-inflammatory cytokines (IL-1β, IL-6 TNF-α) serum mice. disturbed composition microbiota, especially, Faecalibaculum Allobaculum, positively correlated with CCK, GLP-1, 5-HT, IL-1β, TNF-α, played certain role regulating host appetite. In conclusion, changes (especially increase abundance Allobaculum) promote upregulation hormones, neurotransmitters, cytokines, may be mechanism anorexia.
Language: Английский
Citations
4
Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142838 - 142838
Published: Jan. 10, 2025
Language: Английский
Citations
0
Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154126 - 154126
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 5, 2024
Melatonin, a pleiotropic hormone plays vital role in enhancing livestock performance not only by regulating circadian rhythms but also exhibiting antioxidant, immunomodulatory, and metabolic regulatory effects that collectively improve resilience, fertility, productivity. Melatonin's synthesis is predominantly influenced light exposure, with increased production darkness; however, factors such as diet health status further modulate its levels. By helping animals adapt to environmental stressors, melatonin boosts immune responses, mitigates chronic illnesses, optimizes efficiency. Its influence extends the hypothalamic-pituitary-gonadal (HPG) axis, secretion, synchronizing estrous cycles, improving embryo viability. This results improved reproductive outcomes through protection of gametes, sperm motility, enhanced oocyte quality, all which benefit fertilization process. Additionally, positively impacts productive performance, promoting muscle growth, development, optimizing milk yield composition interaction endocrine systems. As ongoing research continues uncover broader physiological effects, supplementation emerges promising approach welfare, productivity, sustainability modern animal husbandry.
Language: Английский
Citations
3
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Trichothecenes (TCNs), Fusarium-derived mycotoxins exemplified by deoxynivalenol and T-2 toxin, threaten global health through multisystem toxicity widespread contamination. Natural phenolic compounds (NPCs), leveraging their intrinsic safety natural abundance, demonstrate multimechanistic efficacy in counteracting TCN toxicity. This article reviews both domestic international research on the protective mechanisms of NPCs against TCN-induced exert effects multitiered mechanisms: (1) molecular regulation via Nrf2-centric antioxidant activation MAPK/NF-κB inflammatory axis suppression, coupled with coordinated inhibition programmed cell death pathways (apoptosis/ferroptosis/pyroptosis) autophagy modulation, where GPX4 emerges as a critical ferroptosis regulator; (2) restoring microbiome balance, enhancing intestinal barrier function, optimizing nutrient transport. Gut microflora may also serve an additional target for mitigating TCNs. further inhibit Fusarium proliferation mycotoxin biosynthesis. While there is demonstrated potential food sustainable feed development, challenges persist bioavailability optimization, pharmacokinetic profiling, microbiota-metabolite crosstalk. analysis advances NPC-based strategies detoxification agriculture.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5491 - 5491
Published: Nov. 21, 2024
T-2 toxin, a highly toxic type A trichothecene, is secondary fungal metabolite produced by various Fusarium species. The consumption of food and feed contaminated with toxin major factor contributing to growth retardation, posing significant risks both human animal health. However, the specific targets mechanisms that mitigate toxin-induced retardation remain unclear. In this study, transcriptomic analysis was employed identify key differentially expressed genes associated alleviation retardation. Peroxiredoxin 4 (PRDX4), gene linked oxidative stress apoptosis, found be one most downregulated in toxin-treated GH3 cells, an vitro model experiments demonstrated significantly increased reactive oxygen species' production, cell cycle arrest while reducing activity antioxidant enzymes (superoxide dismutase glutathione peroxidase) PRDX4 expression cells. Furthermore, silencing exacerbated whereas overexpression effectively mitigated these effects. These findings highlight protective role counteracting suggesting can serve as therapeutic target for treatment
Language: Английский
Citations
2
Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103476 - 103476
Published: Dec. 19, 2024
Language: Английский
Citations
2