Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses

Reproduction Fertility and Development, Journal Year: 2006, Volume and Issue: 19(1), P. 65 - 65

Published: Dec. 21, 2006

The present review highlights new information on pregnancy recognition and conceptus development implantation in sheep with respect to regulation by progesterone, interferons endogenous retroviruses. After formation of the corpus luteum, progesterone acts endometrium stimulates blastocyst growth elongation a filamentous (embryo/fetus associated extra-embryonic membranes). envelope retroviruses related Jaagsiekte appears intrinsically regulate mononuclear trophectoderm cell proliferation differentiation into trophoblast giant binucleate cells. cells elongating conceptuses secrete interferon-τ, which prevent luteolytic mechanism inhibiting transcription gene for oestrogen receptor α luminal superficial ductal glandular epithelia. These actions oestrogen-induced oxytocin and, therefore, oxytocin-induced pulses prostaglandin F2α. Progesterone downregulation its receptors epithelia correlates temporally reduction anti-adhesive mucin 1and induction secreted galectin 15 (LGALS15) phosphoprotein 1, are proposed adhesion. Interferon-τ endometrial lumenal epithelium induce WNT7A stimulate LGALS15, cathepsin L cystatin C, candidate regulators implantation. number potential contributors maternal establishment continues grow this our limited appreciation complexity key molecules signal transduction pathways that intersect during these developmental processes. goal improving reproductive efficiency preventing embryonic losses occur peri-implantation period domestic ruminants provides challenge increase knowledge function development.

Language: Английский

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Extracellular Vesicles in Luminal Fluid of the Ovine Uterus

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(3), P. e90913 - e90913

Published: March 10, 2014

Microvesicles and exosomes are nanoparticles released from cells can contain small RNAs, mRNA proteins that affect at distant sites. In sheep, endogenous beta retroviruses (enJSRVs) expressed in the endometrial epithelia of uterus be transferred to conceptus trophectoderm. One potential mechanism enJSRVs transfer is via exosomes/microvesicles. Therefore, studies were conducted evaluate uterine luminal fluid (ULF) sheep. Exosomes/microvesicles (hereafter referred as extracellular vesicles) isolated ULF day 14 cyclic pregnant ewes using ExoQuick-TC. Transmission electron microscopy nanoparticle tracking analysis found isolates contained vesicles ranged 50 200 nm diameter. The positive for two common markers (CD63 HSP70) by Western blot analysis. Proteins determined mass spectrometry Extracellular vesicle RNA was analyzed RNAs sequencing RT-PCR. a large number miRNAs including 81 conserved mature miRNAs. Cyclic env gag could delivered heterologous vitro. These support hypothesis deliver conceptus, which important regulate trophectoderm development. Importantly, these idea containing select miRNAs, present likely have biological role conceptus-endometrial interactions establishment maintenance pregnancy.

Language: Английский

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Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones

Immunological Reviews, Journal Year: 2006, Volume and Issue: 214(1), P. 161 - 185

Published: Nov. 7, 2006

Summary: In adult females of many species, a transient population natural killer (NK) cells appears in cycles within the uterine endometrium (lining). Appearance these lymphocytes coincides with specific phases ovarian hormone cycle and/or early pregnancy. Studies rodents, women, and pigs dominate literature suggest (u)NK are an activated subset sharing but not all features circulating or lymphoid organ‐residing NK cells. During successful murine pregnancy, uNK appear to regulate initiation structural changes feed arterial systems that support maternal endometrial tissue at sites implantation subsequent placental development. These changes, which reverse after create higher volume bed flaccid vessels unresponsive vasoactive compounds. unique pregnancy‐associated elevate low‐pressure, nutrient‐rich, blood available conceptuses. Regulation differentiation, activation, functions is only partially known, there lively debate regarding whether how participate infertility spontaneous abortion. This review highlights biology during

Language: Английский

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Expression of Interferon (IFN)-Stimulated Genes in Extrauterine Tissues during Early Pregnancy in Sheep Is the Consequence of Endocrine IFN-τ Release from the Uterine Vein

Endocrinology, Journal Year: 2007, Volume and Issue: 149(3), P. 1252 - 1259

Published: Dec. 6, 2007

The ruminant conceptus synthesizes and secretes interferon (IFN)-τ, which presumably acts via an intrauterine paracrine mechanism to signal maternal recognition of pregnancy. aims this study were determine whether IFN-stimulated genes (ISG) such as ISG15 OAS-1 are differentially expressed in blood cells circulating the uterus ewes; extrauterine components reproductive tract corpus luteum (CL) also express mRNA for these ISG, antiviral activity is greater uterine vein than artery during early concentrations both ISG significantly (P < 0.0001) endometrium jugular 15-d pregnant ewes nonpregnant ewes. 0.05) CL from Immunohistochemistry revealed intense staining large luteal on d 15 Blood had similar concentrations, suggesting that not conditioned by IFN-τ within uterus. By using assay, venous was found contain 500- 1000-fold higher bioactive arterial It concluded releases IFN-τ, induces tissues time

Language: Английский

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EvoDevo and niche construction: building bridges

Journal of Experimental Zoology Part B Molecular and Developmental Evolution, Journal Year: 2008, Volume and Issue: 310B(7), P. 549 - 566

Published: Aug. 28, 2008

Evolutionary developmental biology and niche-construction theory have much in common, despite independent intellectual origins. Both place emphasis on the role of ontogenetic processes evolution. The same historical events shaped them, similar philosophical sociological barriers hindered their respective advances. perspectives maintain that neo-Darwinism needs a macroevolutionary variation such can now be adduced from biology. Some proponents both EvoDevo niche construction propose additional evolutionary mechanisms, specify key for stable extra-genetic forms inheritance. Similarly, each lay "reciprocal causation" relationship between organism environment. We illustrate here how could gain "added value" other, demonstrate perspective potentially provides useful conduit to integrate

Language: Английский

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Paracrine and endocrine actions of interferon tau (IFNT)

Reproduction, Journal Year: 2017, Volume and Issue: 154(5), P. F45 - F59

Published: Oct. 6, 2017

This review focuses on the paracrine and endocrine actions of interferon tau (IFNT) during pregnancy recognition establishment in ruminants. Pregnancy involves suppression endometrial luteolytic mechanism by conceptus to maintain progesterone production corpus luteum (CL). The antiluteolytic effects conceptus-derived IFNT inhibit upregulation oxytocin receptors epithelia uterus, thereby preventing prostaglandin F2 alpha (PGF2α) pulses. In endometrium, induces or upregulates a large number classical IFN-stimulated genes (ISGs) regulates expression many other cell-specific manner that are likely important for elongation, implantation pregnancy. Further, has extrauterine cells tissues. sheep, luteal resistance PGF2α, ensuring survival CL maintenance ISGs induced circulating peripheral blood mononuclear may also be useful as an indicator status cattle. An increased knowledge is improve reproductive efficiency

Language: Английский

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Factors of a noninfectious nature affecting fertility after artificial insemination in lactating dairy cows. A review

Theriogenology, Journal Year: 2011, Volume and Issue: 77(6), P. 1029 - 1041

Published: Dec. 10, 2011

Language: Английский

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The role of progesterone in implantation and trophoblast invasion

Journal of Reproductive Immunology, Journal Year: 2013, Volume and Issue: 97(1), P. 43 - 50

Published: Feb. 20, 2013

Language: Английский

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Implantation and Establishment of Pregnancy in Ruminants

Advances in anatomy, embryology and cell biology, Journal Year: 2015, Volume and Issue: unknown, P. 105 - 135

Published: Jan. 1, 2015

Language: Английский

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Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*

Immunological Reviews, Journal Year: 2022, Volume and Issue: 308(1), P. 9 - 24

Published: March 20, 2022

Abstract Pregnancy is a unique condition where the maternal immune system continuously adapting in response to stages of fetal development and signals from environment. The placenta key mediator fetal/maternal interaction by providing that regulate function as well provides protective mechanisms prevent exposure fetus dangerous signals. Bacterial and/or viral infection during pregnancy induce immunological placenta, type I interferon one crucial signaling pathways trophoblast cells. Basal expression interferon‐β downstream ISGs harbors physiological functions maintain homeostasis pregnancy, more importantly, with adequate awareness respond infections. disruption will lead complications can compromise development. In this review, we focus important role placenta‐derived its regulation protection against infection. These studies are helping us better understand placental provide new perspective for developing approaches protect mother

Language: Английский

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