Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 215 - 225
Published: Dec. 25, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 11084 - 11102
Published: April 18, 2024
Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress–inflammation vicious cycle and complicated intercellular crosstalk within ocular microenvironment. Here, nanozyme-based drop, namely nanoceria loading cyclosporin A (Cs@P/CeO2), developed, which possesses long-term antioxidative anti-inflammatory capacities due to its regenerative activity sustained release (CsA). In vitro studies showed that dual-functional Cs@P/CeO2 not only inhibits cellular reactive oxygen species production, sequentially maintaining mitochondrial integrity, but also downregulates inflammatory processes repolarizes macrophages. Moreover, using flow cytometric single-cell sequencing data, in vivo therapeutic effect was systemically demonstrated, rebalances immune–epithelial communication corneal microenvironment less macrophage polarization, restrained stress, enhanced epithelium regeneration. Collectively, our data proved may provide insights into management.
Language: Английский
Citations
18
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops often compromised because bacteria biofilms resist bactericide
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 674, P. 125457 - 125457
Published: March 10, 2025
Language: Английский
Citations
1
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 669 - 669
Published: April 12, 2024
Dry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used treat DED; however, reports indicate that only a minor proportion of drug bioavailability achieved by majority drops available on market. In this context, enhancing ability overcome ocular barriers and prolonging its residence time surface represent new challenge in field carrier systems. Therefore, research has focused development multi-functional nanosystems, such as nanoemulsions, liposomes, dendrimers, hydrogels, other nanosized carriers. These systems designed improve efficacy and, at same time, require fewer daily administrations, with potentially reduced side effects. This review summarizes different nanotechnologies developed, their role DED, nanotechnology-based eyedrops currently approved for DED treatment.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5650 - 5650
Published: May 22, 2024
Nanoparticles (NPs) are becoming increasingly important novel materials for many purposes, including basic research, medicine, agriculture, and engineering. Increasing human environmental exposure to these promising compounds requires assessment of their potential health risks. While the general direct cytotoxicity NPs is often routinely measured, more indirect possible long-term effects, such as reproductive or developmental neurotoxicity (DNT), have been studied only occasionally and, if so, mostly on non-human animal models, zebrafish embryos. In this present study, we employed a well-characterized neuronal precursor cell line test concentration-dependent DNT green-manufactured copper sulfide (CuS) nanoparticles crucial early events in brain development. CuS turned out be generally cytotoxic low ppm range. Using an established prediction model, found clear migration neurite outgrowth, with IC50 values 10 times 5 times, respectively, lower specific endpoint than cytotoxicity. We conclude that, addition opportunities NPs, risks should carefully considered.
Language: Английский
Citations
6
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 306 - 318
Published: July 19, 2024
Language: Английский
Citations
6
BMJ Surgery Interventions & Health Technologies, Journal Year: 2025, Volume and Issue: 7(1), P. e000324 - e000324
Published: Jan. 1, 2025
To address the lack of nerve and blood supply after labial salivary gland transplantation (LSGT) resulting in glandular atrophy. We designed a modified LSGT, called insular infraorbital neurovascular pedicle evaluated postoperative efficacy. This is prospective, single-centre, self-contained study. The research was conducted at Beijing Tongren Hospital, Capital Medical University from July 2019 to March 2024. Eight patients (nine eyes) with severe dry eye disease (DED) were enrolled this All underwent LSGT followed up for least 6 months postoperatively. Key evaluation indices best-corrected visual acuity (BCVA), Ocular Surface Disease Index (OSDI) score, tear break-up time (TBUT), Corneal Fluorescence Staining (CFS) Schirmer I test (SIT). With mean follow-up 17.56±11.72 months, BCVA improved four eyes stabilized five. OSDI score decreased 59.33±14.37 26.27±10.14 (p<0.001). SIT 0.00±0.00 mm 5.44±2.01 (p<0.0001). TBUT increased 0.23±0.48 s 5.48±4.67 (p=0.008). CFS scores 12.56±2.65 7.56±3.09 glands remained viable good supply, no serious complications observed. Insular DED feasible effective treatment, maintaining secretory capacity long-term. ChiCTR2200056015.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Age‐related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the global leading cause of irreversible blindness. Current first‐line therapeutics, vascular endothelial growth factor (VEGF) antagonists, often yield incomplete and suboptimal vision improvement, necessitating exploration novel efficacious therapeutic approaches. Herein, a supramolecular engineering strategy to construct moringin (MOR) loaded α‐cyclodextrin (α‐CD) coated nanoceria (M@CCNP) constructed, where hydroxy newly formed carbonyl groups α‐CD interact with surface via O─Ce conjunction isothiocyanate group MOR inserts deeply into cavity host–guest interaction. By exploiting recycling reactive oxygen species (ROS) scavenging capability anti‐inflammation properties MOR, two‐level strike during AMD pathogenesis can be precisely blocked M@CCNP. Remarkably, excellent efficacy CNV observed in vivo, achieving over 80% reduction 60% leakage area. In summary, engineered provides an efficient approach for amelioration blocking strike, presents significant potential as exceptional drug delivery platform, particularly ROS‐related diseases.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125355 - 125355
Published: Feb. 1, 2025
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)
Published: Feb. 1, 2025
ABSTRACT Nanotechnology has recently attracted research attention, given its wide applications in biomedicine. Novel nontoxic nano drugs functionalized with carbohydrate polymers are widely used vivo bioresearch, but their application to the ocular system remains challenging. Nanostructured materials and nanoparticles other biological macromolecules clinically as eye drops, incorporated into therapeutic contact lenses, wafers nanofibers. Moreover, they can be drug delivery, therapeutic, bioimaging systems for diseases. In this review, ophthalmology delivery based on nanostructured conjugated were investigated. Meanwhile, increasing effect of nano‐drug mucoadhesion by using polymer complexes polysaccharides is discussed. The design pioneering nanomaterials enabled development effective therapies ophthalmology.
Language: Английский
Citations
0