Current Psychology, Journal Year: 2023, Volume and Issue: 43(17), P. 15787 - 15797
Published: Dec. 22, 2023
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: July 27, 2023
MicroRNAs (miRNAs) are short (18-25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates of a number tumor suppressors and oncogenes, its dysregulation is associated with clinical onset different types cancer. Despite fact that numerous therapeutic approaches have been designed in recent years to treat cancer, complexity disease manifested by each patient has prevented development highly effective management strategy. However, over past decade, artificial miRNAs (i.e., anti-miRNAs mimics) shown promising results against various cancer types; nevertheless, their targeted delivery could be challenging. Notably, reports nanotechnology-based can greatly contribute hindering initiation processes, representing an innovative disease-modifying strategy Hence, this review, we evaluate recently developed drug systems therapeutics discuss potential challenges future directions, such as use plant-made nanoparticles, phytochemical-mediated modulation miRNAs, nanozymes.
Language: Английский
Citations
30
Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(4)
Published: March 5, 2024
Abstract Purpose Cancer-related cognitive impairment (CRCI) is a significant risk factor influencing the quality of life in lung cancer survivors. No absolute assessment tool has been confirmed to assess CRCI This review was undertaken pool overall prevalence and summarize tools assessing among Methods PubMed, Cochrane Library, Embase, CINAHL, CNKI were searched retrieve articles reported prevalence. Summary estimates pooled using random effects model, along with corresponding 95% prediction intervals (PIs). The Freeman-Tukey double arcsine transformation proportions incorporated analysis. Additionally, subgroup analysis, meta-regression, leave-one-out analysis performed. Results A total 12 studies, involving 1934 survivors, included review. All these studies found have low bias terms their methodological quality. Four (33.3%) utilized International Cognition Cancer Task Force (ICCTF) criteria identify through neuropsychological tests. rate be 26% (95% PI, 16–37%), I 2 = 95.97%. region which conducted identified as contributing this heterogeneity ( p 0.013). indication small-study (Egger’s test: 0.9191). Conclusion provides an overview findings can serve epidemiological evidence enhance clinicians’ researchers’ understanding early detection assessment.
Language: Английский
Citations
10
Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(6)
Published: May 27, 2024
Abstract Purpose To identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to the sentinel symptoms of each SC. Methods A convenience sampling method was used recruit were their treatment. Patient information collected using General Demographic Questionnaire, MD Anderson Symptom Inventory (including module) a schedule documenting occurrence symptoms. The Walktrap algorithm employed SCs, while within SC identified Apriori conjunction time Results total 169 participated this study, four SCs identified: psychological (difficulty remembering, sadness, dry mouth, numbness or tingling, distress), somatic (pain, fatigue, sleep disturbance, drowsiness), respiratory (coughing, expectoration, chest tightness, shortness breath), digestive (nausea, poor appetite, constipation, vomiting, weight loss). Sadness, coughing as psychological, somatic, respectively. However, no for Conclusion Patients encounter spectrum symptoms, often presenting SCs. emerges earlier than other is characterized by its sensitivity, significance, driving force. It serves vital indicator assumes sentry role. Targeting might be promising strategy determining optimal timing interventions mitigating decelerating progression
Language: Английский
Citations
6
Psychology Research and Behavior Management, Journal Year: 2024, Volume and Issue: Volume 17, P. 1205 - 1219
Published: March 1, 2024
Purpose: Kidney transplant recipients (KTRs) may experience symptoms that increase their fear of progression (FoP), but a dearth research examines the issue from patient-centered perspective. Our study aimed to first determine category symptom burden, then explore differences in characteristics patients different subgroups, and finally analyze impact subgroup on FoP. Patients Methods: Sociodemographic Clinical Characteristics, Symptom Experience Scale, Fear Progression Questionnaire-Short Form were used. Latent class analysis was used group KTRs according occurrence symptoms. We multivariate logistic regression predictors subgroups. The FoP among burden subgroups analyzed by hierarchical multiple regression. Results: Three identified, designated all-high (20.5%), moderate (39.9%), all-low (39.6%) occurrence. Multivariate showed gender, post-transplant time, per capita monthly income, hyperuricemia factors distinguished predicted ( P < 0.05). Hierarchical had significant effect (class1 vs class3: β = 0.327, 0.001; class2 0.104, 0.046), explaining 8.0% variance ΔR2 0.080). Conclusion: generally or low is an influencing factor Identifying traits with high can help clinicians develop targeted management strategies ease KTRs. Keywords: kidney transplant, progression, latent
Language: Английский
Citations
4
Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(4)
Published: March 25, 2025
Language: Английский
Citations
0
Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(5)
Published: April 25, 2024
Abstract Purpose Research on symptom clusters in oncology is progressing, but knowledge gaps remain. One question whether the number and types of subgroups (i.e., latent classes) differ based cancer diagnosis. The purpose this study was to: (1) identify compare class four highly prevalent symptoms (pain, fatigue, sleep disturbance, depression), (2) examine differences sociodemographic clinical factors identified classes across seven prostate, non-small cell lung, non-Hodgkin’s lymphoma, breast, uterine, cervical, colorectal cancer). Methods This a cross-sectional secondary analysis data obtained from My-Health partnership with Surveillance, Epidemiology, End Results (SEER) registries located California (two), Louisiana, New Jersey. sample included 4,762 survivors 6-13 months following diagnosis one mentioned. Latent profile used. Subjects were primarily young (59% age 21-64 years), Caucasian (41%), married/cohabitating (58%) unemployed (55%). varied these populations: four-subgroups common breast survivors. Unmarried, low education, unemployment status associated high risk burden types. Conclusion Identifying by has potential to develop innovative effective targeted interventions Further research needed establish extensive clustering between treatment regimens, short-term long-term
Language: Английский
Citations
2
Asia-Pacific Journal of Oncology Nursing, Journal Year: 2024, Volume and Issue: 11(6), P. 100497 - 100497
Published: April 27, 2024
To identify latent classes of cognitive impairment and co-occurring symptoms (fatigue, pain, sleep disturbance, depression) as clusters in patients with prostate cancer undergoing androgen deprivation therapy to explore the predictors among distinct classes. A total 228 were recruited this cross-sectional study. The assessment instrument included Perceived Cognitive Impairment Scale, Fatigue Severity Athens Insomnia Brief Pain Inventory, Patient Health Questionnaire-9, UCLA Loneliness International Physical Activity Questionnaire - Short Form, Charlson comorbidity index, General Information questionnaire. identification different patient subgroups was done by class analysis. study identified three classes: all low (class 1, 32%), high depression 2, 37.7%), physical pain) 3, 30.3%). Patients who had higher index (P = 0.003) scores more likely be classified 3. loneliness < 0.001; P 0.001) significantly fall into two or than 1. However, having a level activity 0.014; increased likelihood being This exhibited inter-individual variability symptom experience therapy. result suggests that emphasis should placed on screening for fatigue, future interventions focus activity.
Language: Английский
Citations
1
BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 24, 2024
Depression is prevalent among lung cancer patients undergoing chemotherapy, and the symptom cluster of fatigue-pain-insomnia may influence their depression. Identifying characteristics with different depression trajectories can aid in developing more targeted interventions. This study aimed to identify cluster, explore predictive factors associated categories trajectories. In this longitudinal study, 187 who were chemotherapy recruited assessed at first (T1), second(T2), fourth(T3) months using Patient Health Questionnaire-9 (PHQ-9), Brief Pain Inventory (BPI), Fatigue (BFI), Athens Insomnia Scale (AIS). Growth Mixture Model (GMM) Latent Class Analysis (LCA) used Binary logistic regression was utilized analyze depressive GMM identified two trajectories: a high decreasing trajectory (40.64%) low increasing (59.36%). LCA showed that 48.66% likely members trajectory. analysis indicated having history alcohol consumption, higher burden, unemployed, lower monthly income predicted exhibited distinct When managing these patients, it recommended strengthen management pay particular attention individuals income.
Language: Английский
Citations
1
European Journal of Oncology Nursing, Journal Year: 2024, Volume and Issue: 71, P. 102657 - 102657
Published: July 1, 2024
Language: Английский
Citations
0
European Journal of Oncology Nursing, Journal Year: 2023, Volume and Issue: 68, P. 102493 - 102493
Published: Dec. 18, 2023
Language: Английский
Citations
1