Proposed subtypes of post‐COVID‐19 syndrome (or long‐COVID) and their respective potential therapies

Reviews in Medical Virology, Journal Year: 2021, Volume and Issue: 32(4)

Published: Dec. 9, 2021

Summary The effects of coronavirus disease 2019 (COVID‐19), a highly transmissible infectious respiratory that has initiated an ongoing pandemic since early 2020, do not always end in the acute phase. Depending on study referred, about 10%–30% (or more) COVID‐19 survivors may develop long‐COVID or post‐COVID‐19 syndrome (PCS), characterised by persistent symptoms (most commonly fatigue, dyspnoea, and cognitive impairments) lasting for 3 months more after COVID‐19. While pathophysiological mechanisms PCS have been extensively described elsewhere, subtypes not. Owing to its multifaceted nature, this review proposes characterises six based existing literature. are non‐severe multi‐organ sequelae (NSC‐MOS), pulmonary fibrosis (PFS), myalgic encephalomyelitis chronic fatigue (ME/CFS), postural orthostatic tachycardia (POTS), post‐intensive care (PICS) medical clinical (MCS). Original studies supporting each these documented review, as well their respective potential interventions. Ultimately, subtyping proposed herein aims provide better clarity current understanding PCS.

Language: Английский

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ESCMID rapid guidelines for assessment and management of long COVID

Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(7), P. 955 - 972

Published: Feb. 17, 2022

Language: Английский

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A systematic review on physical function, activities of daily living and health-related quality of life in COVID-19 survivors

Chronic Illness, Journal Year: 2022, Volume and Issue: 19(2), P. 279 - 303

Published: April 11, 2022

To analyze the published studies that investigated physical function, activities of daily living and health-related quality life in COVID-19 survivors.Systematic review.We searched MEDLINE/PubMed, Scopus, SciELO, Cochrane Library for evaluated after from earliest date available to July 2021. Two independent reviewers screened selected studies. The Newcastle Ottawa Scale was used evaluate methodological quality.We included 35 this systematic review. Of included, 28 were cohort, 7 cross-sectional demonstrated survivors had reduced levels living, life. Furthermore, incomplete recovery performance observed 1 6 months post-infection.Physical disability reduction is a common condition post-COVID-19 impairments may persist up months. Researchers clinicians can use these findings understand potential disabilities rehabilitation needs people recovering COVID-19.

Language: Английский

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Effect of Pulmonary Rehabilitation Approaches on Dyspnea, Exercise Capacity, Fatigue, Lung Functions, and Quality of Life in Patients With COVID-19: A Systematic Review and Meta-analysis

Archives of Physical Medicine and Rehabilitation, Journal Year: 2022, Volume and Issue: 103(10), P. 2051 - 2062

Published: July 29, 2022

Language: Английский

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S1-Leitlinie Long-/Post-COVID

Pneumologie, Journal Year: 2022, Volume and Issue: 76(12), P. 855 - 907

Published: Dec. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

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Measures of physical performance in COVID-19 patients: a mapping review

Pulmonology, Journal Year: 2021, Volume and Issue: 27(6), P. 518 - 528

Published: June 24, 2021

There is evidence of short- and long-term impairment physical performance in patients with COVID-19 infection, but a verification measures this condition lacking. We reviewed the used to assess these patients. Secondary targets were exercise or daily life activities induced symptoms.Medline, CINAHL, Pedro databases searched from January 2020 February 2021 for articles English language. Two investigators independently conducted search, screened all titles and/or abstracts based on inclusion criteria scored studies. The quality studies was evaluated by two reviewers according NIH assessment tool observational cohort cross-sectional Discrepancies resolved through consensus.Out 156 potentially relevant articles, 31 (8 cross-sectional), 1 randomized controlled trial, protocol included. most evaluable judged as low (11 studies) fair (14 studies). Sample sizes ranged 14 20,889 among 28 reported measures, Barthel Index (42.4% studies), Six-Minute Walking Distance Test (36.4%), Short Physical Performance Battery (21.2%) 1-Minute Sit-to-Stand (12.1%) used. Fifteen% 36% desaturation dyspnoea when performing assessments, respectively. Other symptoms fatigue pain. Studies wide ranges compared "reference" values (range mean median vs "reference values": 11-77 100 points Index; 11-22 22-37 repetitions/min 1m-STS; 0.5-7.9 11.4 ± 1.3 SPPB; 45-223 380-782 m 6MWT respectively).This review found that variety functional status tests have been used, making comparisons difficult between These show However, fair.

Language: Английский

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Feasibility of Virtual Reality Exercises at Home for Post–COVID-19 Condition: Cohort Study

JMIR Rehabilitation and Assistive Technologies, Journal Year: 2022, Volume and Issue: 9(3), P. e36836 - e36836

Published: July 19, 2022

Between 30% to 76% of COVID-19 patients have persistent physical and mental symptoms, sometimes up 9 months after acute COVID-19. Current rehabilitation is mostly focused on the whereas experts agreed need for a biopsychosocial approach. A novel approach such as virtual reality (VR) at home might benefit therapists, especially considering expected rush with post-COVID-19 condition needing rehabilitation.The aim this study was investigate feasibility self-administered VR exercises condition.This single-arm in an outpatient care setting. Patients who needed physiotherapy because were included determined by treating physiotherapist. Participants performed period 6 weeks allowed perform exercise through applications available platform reduce stress anxiety promote cognitive functioning. The main outcomes related (ie, duration frequency use), safety adverse events), patient satisfaction, reasons withdraw. Physical performance, daily activities, functioning, depression, quality life measured before after.In total, 48 included; 1 (2%) did not start VR, 7 (15%) withdrew, due dizziness. Almost 70% (33/47) participants reported experiencing any event during exercising. However, only 25% (9/36) recalled these events end intervention period. majority (27/36, 75%) described having positive influence their recovery, global satisfaction score 67%. average use 30 minutes per session, 3-4 times week 3-6 weeks. overall almost equally distributed over 3 sets (physical, relaxing, cognitive). seemed decrease time, relaxation remained stable. performance significantly improved weeks.VR feasible safe good acceptance significant percentage condition.ClinicalTrials.gov NCT04505761; https://clinicaltrials.gov/ct2/show/NCT04505761.

Language: Английский

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Effect of Physical Exercise–Based Rehabilitation on Long COVID: A Systematic Review and Meta-analysis

Medicine & Science in Sports & Exercise, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

The number of persons living with post-coronavirus disease 2019 (COVID-19) conditions or long COVID continues to rise worldwide; however, the etiology and treatment remain nebulous. Therefore, efficient, feasible, cost-effective therapeutic strategies for a large population warranted. Physical exercise-based rehabilitation is promising strategy COVID, although its effects be determined. This systematic review meta-analysis aimed examine physical on COVID.The electronic databases Medline, Embase, Global Health (Ovid), CINAHL (EBSCO), Web Science, WHO Research Database COVID-19, LitCovid, Google Scholar were searched from their inception November 2022. identified articles independently screened by three reviewers, random-effects model was used determine mean differences in meta-analysis.Twenty-three studies involving 1579 individuals who had COVID-19 (752 women) included. showed beneficial COVID-related symptoms characterized dyspnea, fatigue, depression, as well 6-min walk test, forced expiratory volume 1 s/forced vital capacity, quality life people COVID-19.Physical potential against can applied routine clinical practice have recovered COVID-19. However, customized programs specific types require future large-scale studies.

Language: Английский

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Grip strength as a predictor of disease severity in hospitalized COVID-19 patients

Heart & Lung, Journal Year: 2021, Volume and Issue: 50(6), P. 743 - 747

Published: June 11, 2021

Language: Английский

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Efficacy of Therapeutic Exercise in Reversing Decreased Strength, Impaired Respiratory Function, Decreased Physical Fitness, and Decreased Quality of Life Caused by the Post-COVID-19 Syndrome

Viruses, Journal Year: 2022, Volume and Issue: 14(12), P. 2797 - 2797

Published: Dec. 15, 2022

In the current global scenario, many COVID-19 survivors present a severe deterioration in physical strength, respiratory function, and quality of life due to persistent symptoms post-acute consequences SARS-CoV-2 infection. These alterations are known as post-COVID-19 syndrome for which there is no specific effective treatment their management. Currently, therapeutic exercise strategies (ThEx) diseases by reducing appearance complications side effects linked treatment, consequently great relevance. this study, we review effect ThEX reversing decreased impaired fitness, (QoL) caused syndrome. A literature search was conducted through electronic databases, Medline (PubMed), SciELO Cochrane Library Plus structured narrative studies published from database retrieval up till 12 December 2022. total 433 patients with condition (60% women) were included nine met inclusion/exclusion criteria. Overall, who followed ThEx intervention showed improvements fitness QoL, exercise-derived effects. Thus, based on aerobic training could be an adjuvant non-pharmacological tool modulation

Language: Английский

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