Functionality, physical activity, fatigue and quality of life in patients with acute COVID-19 and Long COVID infection

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 14, 2023

A prominent feature of COVID-19, both in the short and long term, is reduction quality life (QoL) due to low functionality scores presence fatigue, which can hinder daily activities. The main objective this study compare functional status, level physical activity, QoL patients with Long COVID other COVID-19 who did not develop persistent illness, determine whether there a relationship between these variables QoL. cross-sectional was conducted 170 participants had been infected or developed COVID. studied were functionality, measured using PostCOVID-19 Functional Status Scale (PCFS), International Physical Activity Questionnaire (IPAQ), Short Form 12 (SF-12), Fatigue Severity (FSS). findings show significant (p < 0.001) reduced lower activity levels, increased fatigue severity, poorer patients. Furthermore, are also related worse QoL, but only status predicts it. In conclusion, our results have shown highly correlations group regarding fatigue.

Language: Английский

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Effects of a randomized-controlled and online-supported physical activity intervention on exercise capacity, fatigue and health related quality of life in patients with post-COVID-19 syndrome

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 2, 2024

Abstract Background The Post-COVID-19 syndrome (PCS), which can occur after acute respiratory coronavirus 2 infection, leads to restrictions in everyday activity. Our study assessed the impact of an online-guided intervention intended facilitate physical activity on mental and capability PCS patients. Methods We randomized 62 patients with (20 male/ 42 female; age: 46 ± 12 years; body mass index: 28.7 6.7 kg/m ) a score ≥ 22 fatigue assessment scale (FAS) 3-month exercise-focused (IG n = 30) or control period (CG 32). changes exercise capacity (bicycle test measurements gas exchange), fatigue, markers health-related quality life (HrQoL) health. Results FAS decreased significantly both groups (IG: 35.1 7.4 31.8 8.5 points; CG: 35.6 32.6 7.5 points, p < 0.01). Exercise did not increase CG IG (within-group for IG: peak oxygen uptake: 0.9 2.6 ml/min/kg, 0.098; power output: 6.1 17.8 W, 0.076) no significant HrQoL work ability. Patients at baseline 35 (severe fatigue) showed change whereas sub-group points (moderate improvements, independent group. Conclusions seems appropriate moderate those more severe appear be too restricted respect their health status perform level is sufficient improve performance. Trial registration German Clinical Trials Register (registration trial number: DRKS00026245) September 2021.

Language: Английский

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Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19

CHEST Journal, Journal Year: 2024, Volume and Issue: 166(3), P. 461 - 471

Published: Jan. 19, 2024

Language: Английский

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Impact of Melatonin Supplementation on Sports Performance and Circulating Biomarkers in Highly Trained Athletes: A Systematic Review of Randomized Controlled Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1011 - 1011

Published: March 30, 2024

Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose this study was critically review effects melatonin supplementation in sports performance circulating biomarkers related health status highly trained athletes. Data were obtained by performing searches following three bibliography databases: Web Science, PubMed, Scopus. The terms used “Highly Trained Athletes”, “Melatonin”, “Sports Performance”, “Health Biomarkers” using “Humans” as filter. search update carried out February 2024 from original articles published with controlled trial design. PRISMA rules, modified McMaster critical form for quantitative studies, PEDro scale, Cochrane risk bias applied. According inclusion exclusion criteria, 21 selected 294 references. dose supplemented trials ranged between 5 mg 100 administered before or after exercise. outcomes showed improvements antioxidant inflammatory response reversed liver damage muscle damage. Moderate on modulating glycemia, total cholesterol, triglycerides, creatinine reported. Promising data found regarding potential benefits hematological biomarkers, hormonal responses, performance. true efficiency directly improve remains be assessed. Nevertheless, indirect effect could evaluated through biomarkers.

Language: Английский

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Long COVID-19 Syndrome Severity According to Sex, Time from the Onset of the Disease, and Exercise Capacity—The Results of a Cross-Sectional Study

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 508 - 508

Published: Feb. 11, 2023

Symptoms of long COVID-19 syndrome (long COVID-19) are reported by 80% convalescents up to several months after contracting the coronavirus-19 disease (COVID-19). The study aimed assess frequency and correlations COVID symptoms with sex, severity, time since onset disease, exercise capacity in a population Polish hospitalized as part rehabilitation program COVID-19. retrospective analysis was carried out based on medical records concerning symptoms, comorbidities, capacity, fatigue dyspnea Borg's scale, arterial oxygen saturation (SpO2), spirometric parameters, chest X-rays/computed tomography scans, systolic pulmonary artery pressure, left ventricular ejection fraction. involved 471 patients aged 63.83 ± 9.93 years who had been 191.32 75.69 days from COVID-19, which 269 (57.1%) were women. most common (99.57%), (99.36%), myalgia (97.03%). Women more than men (p < 0.001) rated their severe = 0.021). Patients depressed moods physical others 0.001). Most including dyspnea, fatigue, depressive found same 12-24 weeks >24 recovery 0.874, p 0.400, 0.320, respectively), regardless acute severity 0.240, 0.826, 0.108, respectively). Dyspnea correlated forced vital (FVC) (r -0.153, 0.005), expiratory volume one second (FEV1) -0.142, 0.008). Fatigue impaired FVC FEV1 (both r -0.162, 0.003). inversely distance six-minute walk test -0.497, 0.001, -0.327, In conclusion, our cohort, Dyspnea/fatigue do not tend subside an average six-month period. intensity perceived may be exaggerated coexistence neuropsychiatric disorders. Increased correlate parameters significantly affects convalescents' capacity.

Language: Английский

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The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 29, 2024

Abstract Background and aims A healthy diet play an important role in the prevention even treatment of various diseases. Proper nutrition plays boosting immune system. These include consumption macronutrients such as proteins, lipids, carbohydrates, also micronutrients including vitamins. Here, we aimed to systematically review effects on COVID-19. Methods We searched databases PubMed, Scopus, Embase, Web Science December 23, 2023. The records were downloaded into EndNote file, duplicates removed, studies underwent a two-phase screening process based their title/abstracts full texts. included articles screened inclusion exclusion criteria. English systematic reviews meta-analyses that concurred with aim our study. selected assessed by Cochrane's Risk Bias Systematic Reviews for quality check. data eligible extracted pre-designed word table used qualitative synthesis. Results total 28 this Most have shown are effective morbidity mortality controlling viral respiratory infections COVID-19 but some sometimes not severity. On other hand, calcifediol was far most successful agent reducing intensive care needs between studies. Conclusion Individuals without malnutrition had reduced risk SARS-CoV-2 infection severe disease. administration Vitamin D is patients. Patients vitamin deficiency more prone experience infection, they at higher morbidities mortality. Other A, B, Zinc showed benefits patients C no efficacy management intravenous form or high doses.

Language: Английский

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Precision management of post‐COVID pain: An evidence and clinical‐based approach

European Journal of Pain, Journal Year: 2023, Volume and Issue: 27(9), P. 1107 - 1125

Published: Feb. 28, 2023

Abstract Background Pain after a SARS‐CoV‐2 acute infection (post‐COVID pain) is becoming new healthcare emergency but remains underestimated and most likely undertreated due to lack of recognition the phenomenon knowledge underlying pain mechanisms. Evidence supporting any particular treatment approach for management post‐COVID lacking. Large variability in patient response standard treatments clinically observed, which has led calls personalized, tailored treating patients with chronic (i.e. ‘precision medicine’). Applying global concerted action towards precision medicine could help guide clinical decision‐making aid more effective treatments. Methods The current position paper discusses factors be considered by clinicians managing ranging from identification phenotype genetic consideration. Results ability into nociceptive, neuropathic, nociplastic or mixed type suggested as first step better planification programme. Further, consideration other factors, such gender, comorbidities, received at phase onset‐associated COVID‐19 symptoms, during hospitalization presence emotional disturbances should implemented Conclusions Accordingly, considering these include multimodal pharmacological non‐pharmacological modalities targeting emotional/cognitive aspects psychological and/or coping strategies), central sensitization‐associated mechanisms neuroscience education), exercise programmes well lifestyle interventions (e.g. nutritional support sleep management). Significance This presents an evidence‐based reasoning pain.

Language: Английский

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Respiratory training effects in Long COVID-19 patients: a systematic review and meta-analysis

Expert Review of Respiratory Medicine, Journal Year: 2024, Volume and Issue: 18(3-4), P. 207 - 217

Published: April 2, 2024

Introduction To date, it is unknown whether respiratory training interventions can benefit Long COVID-19 patients. The main objective was to analyze the effects of on patients with COVID-19, concretely muscle strength, lung function, dyspnea, and functional capacity.

Language: Английский

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Optimizing Pulmonary Rehabilitation in Saudi Arabia: Current Practices, Challenges, and Future Directions

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 673 - 673

Published: April 6, 2025

Chronic respiratory diseases (CRDs) are a significantly major cause of mortality in Saudi Arabia, with their progression frequently involving comorbidities and exacerbations that extend beyond the lungs. This review considers current state pulmonary rehabilitation (PR) this being well-known non-pharmacological intervention to help control reduce burden CRDs, highlighting intervention’s availability, multidisciplinary approach, integration within healthcare system, as well examining diseases’ contribution overall symptom severity, impairing daily activities worsening patient’s quality life. Although PR is strongly recommended for managing its utilization Arabia remains limited or unavailable many regions. Key barriers access include inadequate awareness among providers patients, logistical challenges, an insufficient number specialized facilities trained professionals. Expanding programs requires addressing geographical barriers, ensuring adequate space, resources, personnel, raising through education training. Integrating principles into medical offering incentives specialization can overcome personnel shortages. Additionally, promoting telerehabilitation enhance patient compliance ensure long-term success programs. These initiatives aim optimize services improve outcomes across nation.

Language: Английский

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Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 14, 2024

Introduction Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both persistent and post-acute disease newly acquired symptoms are not yet fully described. Given lack robust knowledge regarding mechanisms PCC we have examined impact inflammation in PCC, evaluating serum cytokine profile its potential involvement inducing different Methods In this cross-sectional study, recruited 227 participants who were hospitalised acute COVID-19 2020 came back for follow-up assessment 6–12 months after hospital discharge. enrolled two symptomatic groups: Self-Reported Symptoms group (SR, n = 96), did present major organ lesions, reported several debilitating such fatigue, muscle weakness, loss sense smell taste; decreased Pulmonary Function (SRPF, 54), composed individuals same described SR, plus diagnosed pulmonary lesions. A Control ( 77), minor complaints following COVID-19, was also included study. Serum levels, symptom questionnaires, physical performance tests general clinical data obtained assessment. Results SRPF presented lower IL-4 concentration compared q 0.0018) SR 0.030), IFN-α2 content 0.007). addition, higher MIP-1β 0.029). CCL11 0.012 0.001, respectively) MCP-1 levels 0.052 both) SRPF. G-CSF to 0.014). Female showed handgrip strength relation 0.0082). Male needed more time complete timed up-and-go test, men 0.0302 0.0078, respectively). Our results indicate profiles accompanied distinct inflammatory markers circulation. Of particular concern function findings, likely long-lasting consequences health quality life, found phenotypes.

Language: Английский

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