Multifunctional Microneedle Patch Based on Metal-Phenolic Network with Photothermal Antimicrobial, ROS Scavenging, Immunomodulatory, and Angiogenesis for Programmed Treatment of Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33205 - 33222

Published: June 25, 2024

In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, promoting are necessary for treating acute wounds. this study, benefiting from ability polyphenols to form a metal-phenolic network (MPN) metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs TM then loaded onto supporting base needle tips PVA/HA (PH) microneedles, respectively, obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles could remove bacteria by effect. vitro effectively scavenge inhibit macrophage polarization M1 type, induce M2 type as well have promote vascular endothelial cell migration angiogenesis. Furthermore, vivo accelerated inhibiting pro-inflammatory cytokines rat model. efficient antibacterial, ROS scavenging, anti-inflammatory, immunomodulatory, angiogenic abilities hold promise dressings

Language: Английский

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Photo-crosslinking Injectable Photothermal Antibacterial hydrogel based on Quaternary Ammonium Grafted Chitosan and Hyaluronic Acid for Infected Wound Healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101265 - 101265

Published: Sept. 23, 2024

Language: Английский

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Sericin-based conductive hydrogel loaded with MXene@TA-Eu nanosheets promotes the healing of infected wounds through photothermal antibacterial and electrical stimulation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159738 - 159738

Published: Jan. 1, 2025

Language: Английский

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Sericin-Assisted Green Synthesis of Gold Nanoparticles as Broad-Spectrum Antimicrobial and Biofilm-Disrupting Agents for Therapy of Bacterial Infection

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3559 - 3574

Published: March 1, 2025

Tens of millions people die from wound infections globally each year, and nearly 80% tissue are associated with bacterial biofilms. However, overuse antibiotics can lead to resistance. Therefore, it is critical develop simple effective strategies kill bacteria remove The present study used sericin as a reducing stabilizing agent synthesize sericin-gold nanoparticles (Ser-Au NPs) tested its colloidal stability under different pH salt concentration conditions. Subsequently, functional gold nanocomposites (Ser-Au@MMI) were synthesized by combining Ser-Au NPs 2-mercapto-1-methylimidazole (MMI). antimicrobial effect Ser-Au@MMI was checked MIC, activity test, in vitro cytotoxicity assessed using CCK-8 assay. In anti-biofilm observed fluorescence microscopy SEM. Finally, the anti-infective therapeutic efficacy determined an vivo rat-infected model. Sericin exhibited excellent TEM, EDS, XPS analyses confirmed successful synthesis Ser-Au@MMI. It higher antibacterial due synergistic MMI AuNP, which achieve bactericidal destroying integrity cell walls structure. addition, Ser-Au@MMI10 (HAuCl4:MMI =1:10) (64 μg/mL) could effectively disrupt biofilms formed four species them, including P. aeruginosa, B. subtilis, E. coli, S. aureus, but not cytotoxic mouse fibroblasts (L929) cells. Infected modeling showed that accelerated infected healing vivo. prepared through facile environmentally friendly strategy have advantages low toxicity, has potential for application broad-spectrum biofilm disrupting healthcare.

Language: Английский

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Lessons from Nature: Advances and Perspectives in Bionic Microwave Absorption Materials

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 30, 2024

Inspired by the remarkable electromagnetic response capabilities of complex morphologies and subtle microstructures evolved natural organisms, this paper delves into research advancements future application potential bionic microwave-absorbing materials (BMAMs). It outlines significance achieving high-performance through ingenious microstructural design judicious composition selection, while emphasizing innovative strategies offered manufacturing. Furthermore, work meticulously analyzes how inspiration can be drawn from intricate structures marine plants, animals, non-metallic minerals in nature to devise develop BMAMs with superior wave absorption properties. Additionally, provides an in-depth exploration theoretical underpinnings BMAMs, particularly latest breakthroughs broadband absorption. By incorporating advanced methodologies such as simulation modeling gradient design, we unravel scientific principles governing microwave mechanisms thereby furnishing a solid foundation for understanding optimizing their performance. Ultimately, review aims offer valuable insights researchers related fields, fostering collective advancement on BMAMs.

Language: Английский

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A brief strategy for the preparation of silk fibroin-copper sulfide-based electrospun nanofibrous membranes with photothermal antimicrobial properties to accelerate the infected wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101605 - 101605

Published: Feb. 21, 2025

Language: Английский

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Nature-Inspired Healing: Biomimetic Nanomaterials for Advanced Wound Management

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 100975 - 100975

Published: Sept. 6, 2024

Language: Английский

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A flat-drawn silk fibre membrane based composite antibacterial and conductive wound dressing

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102478 - 102478

Published: Oct. 30, 2024

Language: Английский

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