Matéria (Rio de Janeiro),
Journal Year:
2024,
Volume and Issue:
29(4)
Published: Jan. 1, 2024
ABSTRACT
The
increase
in
hospital-acquired
infections
(HAIs)
associated
with
medical
devices
underscores
the
need
for
antimicrobial
coatings.
This
study
aims
to
compare
efficacy,
biocompatibility,
ion
release,
and
durability
of
silver
nanoparticles,
copper
coatings,
zinc
oxide
nanostructures
as
coatings
devices.
Coatings
were
prepared
characterized,
efficacy
tested
against
E.
coli
S.
aureus
via
inhibition
zone
measurements.
Silver
demonstrated
highest
effect,
zones
averaging
90%,
while
showed
moderate
80%
70%,
respectively.
Biocompatibility,
assessed
using
human
fibroblasts
an
MTT
assay,
cell
viability
oxide,
followed
by
silver.
Durability
tests
under
simulated
physiological
conditions
indicated
that
retained
over
90%
structural
integrity,
greater
degradation.
Ion
release
profiles
highlighted
silver’s
rapid
ideal
short-term
activity,
steady,
sustained
release.
These
findings
suggest
immediate
infection
control,
offer
balanced
long-term
safety
durability,
making
them
suitable
extended
applications
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(15), P. 18449 - 18458
Published: April 5, 2024
Developing
novel
antibacterial
strategies
has
become
an
urgent
requisite
to
overcome
the
increasing
pervasiveness
of
antimicrobial-resistant
bacteria
and
advent
biofilms.
Aggregation-induced
emission-based
photosensitizers
(AIE
PSs)
are
promising
candidates
due
their
unique
photodynamic
photothermal
properties.
Bioengineering
structure-inherent
AIE
PSs
for
developing
thin
film
coatings
is
still
unexplored
area
in
field
nanoscience.
We
have
adopted
a
synergistic
approach
combining
plasma
technology
PS-based
therapy
develop
that
can
eradicate
bacterial
infections.
Here,
we
loaded
within
biomimetic
bacterium-like
particles
derived
from
probiotic
strain,
Lactobacillus
fermentum.
These
hybrid
conjugates
then
immobilized
on
polyoxazoline-coated
substrates
bioinspired
coating
fight
against
implant-associated
could
selectively
kill
Gram-positive
Gram-negative
bacteria,
but
not
damage
mammalian
cells.
The
mechanistic
studies
revealed
generate
reactive
oxygen
species
rupture
cell
membranes.
mRNA
gene
expression
proinflammatory
cytokines
confirmed
they
modulate
infection-related
immune
responses.
Thus,
this
nature-inspired
design
opened
new
avenue
fabrication
next-generation
reduce
infections
associated
burdens.
International Journal of Community Medicine and Public Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Surgical
site
infections
(SSIs)
remain
a
significant
challenge
in
surgical
care,
posing
substantial
threat
to
postoperative
morbidity
and
mortality.
There
are
many
risk
factors
that
can
cause
SSIs,
encompassing
patient-related
healthcare
team
practices.
The
for
SSIs
include
advanced
age,
diabetes,
smoking,
obesity,
distant
infections,
elevated
biomarkers,
low
HDL
levels,
opioid
addiction,
immunosuppressive
drug
use,
higher
ASA
grade,
comorbidities,
prolonged
preoperative
hospitalization,
antibiotic
resistance.
Preoperative,
intraoperative,
precautions
have
all
been
used
as
part
of
comprehensive
preventative
efforts
reduce
the
incidence
SSIs.
Furthermore,
emerging
technologies,
such
artificial
intelligence
machine
learning,
demonstrated
potential
enhancing
SSI
detection
prevention,
offering
promising
advancements
further
optimize
outcomes.
This
review
aims
explore
current
evidence,
factors,
strategies
prevention.
By
understanding
multifactorial
nature
implementing
preventive
measures,
providers
significantly
mitigate
burden
these
ultimately
improving
patient
outcomes
overall
quality
care.
This
study
explores
the
synergistic
effects
of
combining
titania
nanotubes
(TiNTs)
with
biopolymer
Tanfloc
(TAN)
to
enhance
surface
properties
TiNTs
for
biomedical
applications.
We
investigated
interactions
blood
components
and
human
adipose-derived
stem
cells
(ADSCs)
TiNT
surfaces
covalently
functionalized
(TAN),
an
aminolyzed
polyphenolic
tannin
derivative.
The
(TiNT-TAN)
have
great
potential
control
protein
adsorption
platelet
adhesion
activation.
Fluorescence
scanning
electron
microscopy
(SEM)
were
used
analyze
adherence
amphoteric
nature
multiple
functional
groups
on
TAN
can
adsorption,
adhesion,
Further,
modified
supports
cell
(ADSC)
viability,
attachment,
growth
without
any
cytotoxic
effect.
conjugation
significantly
(****p
<
0.0001)
increased
proliferation
rate
ADSCs
compared
surfaces.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 108 - 108
Published: March 19, 2025
Loss
of
implant
function
is
a
common
complication
in
orthopaedic
and
dental
surgery.
Among
the
primary
causes
failure
are
peri-implant
infections
which
often
result
removal.
This
study
demonstrates
development
new
antimicrobial
titanium
coating
with
ZnO
nanoparticles
various
sizes
morphologies
immobilised
poly(allylamine
hydrochloride)
alginate
multilayers,
combined
epitaxially
grown
vaterite
crystals.
The
coated
samples
were
characterised
methods
(FTIR,
XRD,
SEM)
surface
properties
evaluated
via
water
contact
angle
charge
measurements.
Zinc
ion
release
was
quantified
using
ICP-MS.
efficacy
coatings
tested
against
Staphylococcus
aureus,
epidermidis,
Candida
albicans
while
biocompatibility
preosteoblast
cells
(MC3T3-E1).
Results
demonstrated
successful
preparation
calcium
carbonate/ZnO
composite
on
surfaces.
Zn
ions
released
from
dramatically
influenced
morphology
where
flower-like
observed.
surfaces
exhibited
robust
activity,
achieving
over
90%
microbial
viability
reduction
for
albicans.
Importantly,
Zn2+
concentrations
remained
below
cytotoxicity
limit
MC3T3-E1
cells,
showing
potential
safe
effective
applications.
