Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(8), P. 3847 - 3884
Published: Sept. 19, 2023
Language: Английский
Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 211, P. 115522 - 115522
Published: March 28, 2023
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that affect millions people worldwide, with both prevalence and incidence increasing age. It characterized by cognitive decline associated, specifically, degeneration cholinergic neurons. The problem this even more fundamental as available therapies remain fairly limited mainly focused on symptoms' relief. Although aetiology remains elusive, two main pathological hallmarks are described: i) presence neurofibrillary tangles formed unfolded protein aggregates (hyperphosphorylated Tau protein) ii) extracellular amyloid-beta peptide. Given complexity surrounding pathogenesis disease, several potential targets have been highlighted interrelated upon its progression, such oxidative stress accumulation metal ions. Thus, advances made development innovative multitarget therapeutical compounds to delay progression restore cell function. This review focuses ongoing research new insights emerging disease-modifying drugs for AD treatment. Furthermore, classical novel biomarkers early diagnosis their role in assisting improvement targeted will also be approached.
Language: Английский
Citations
126
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: April 12, 2024
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) certain stimuli such as trauma, infection, and neurodegenerative diseases. This is cellular immune response whereby glial cells are activated, inflammatory mediators liberated reactive oxygen nitrogen species synthesized. key process that helps protect brain from pathogens, but inappropriate, or protracted inflammation yields pathological states Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, other disorders showcase various pathways neurodegeneration distributed in parts CNS. review reveals major neuroinflammatory signaling associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, stem cell therapy, genetic intervention, nanoparticles, aiming regulate neuroinflammation potentially impede decelerate advancement these conditions. A comprehensive understanding intricate connection between diseases pivotal for development future treatment strategies can alleviate burden imposed by devastating disorders.
Language: Английский
Citations
101
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(3), P. 916 - 941
Published: Oct. 27, 2022
RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets diagnostic biomarkers. However, efficient delivery RNA to targeted location precise detection markers remains challenging. Recently, more attention has been paid applying nucleic acid nanoassemblies diagnosing treating. Due flexibility deformability acids, could be fabricated with different shapes structures. With hybridization, nanoassemblies, including DNA nanostructures, can applied enhance therapeutics diagnosis. This review briefly introduces construction properties their applications for therapy diagnosis makes further prospects development.
Language: Английский
Citations
84
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 191, P. 114583 - 114583
Published: Oct. 19, 2022
Language: Английский
Citations
78
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2599 - 2599
Published: Nov. 7, 2023
Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is tightly packed layer of endothelial cells that shields brain from harmful substances blood, allowing necessary nutrients to pass through. It highly selective barrier, which poses challenge delivering therapeutic agents into brain. Several non-invasive procedures and devices have been developed or are currently being investigated enhance BBB. This paper presents review prospective analysis art science address pharmacology, technology, systems, regulatory approval, ethical concerns, future possibilities.
Language: Английский
Citations
44
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102357 - 102357
Published: June 1, 2024
Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both medicine and public health in the upcoming years due global demographic changes. NDs mainly represented by degeneration/loss of neurons, which is primarily accountable severe mental illness. This neuronal degeneration leads many neuropsychiatric problems permanent disability an individual. Moreover, tight junction brain, blood-brain barrier (BBB)has protective feature, functioning as biological that can prevent medicines, toxins, foreign substances from entering brain. However, delivering any medicinal agent brain (i.e., Multiple sclerosis, Alzheimer's, Parkinson's, etc.) enormously challenging. There approved therapies address NDs, but most them only help treat associated manifestations. The available have failed control progression certain factors, i.e., BBB drug-associated undesirable effects. extremely complex pathology, with pathogenic mechanisms involved initiation progression; thereby, limited survival rate has been observed ND patients. Hence, understanding exact mechanism behind crucial developing alternative approaches improving patients' rates. Thus, present review sheds light on different cellular novel therapeutic their clinical relevance, will assist researchers alternate strategies limitations conventional therapies. current work offers scope into near future improve approach NDs.
Language: Английский
Citations
35
ACS Nano, Journal Year: 2024, Volume and Issue: 18(18), P. 11753 - 11768
Published: April 22, 2024
The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental pathological event increases the speed of Alzheimer's disease (AD). Additionally, pathogenesis AD intricate single drug may not be enough to achieve satisfactory therapeutic outcome. Herein, we reported facile effective gene therapy strategy for modulation function intervention Aβ anabolism by ROS-responsive biomimetic exosome-liposome hybrid nanovesicles (designated as TSEL). codelivery β-site amyloid precursor protein cleaving enzyme-1 (BACE1) siRNA (siBACE1) TREM2 plasmid (pTREM2) efficiently penetrate blood-brain barrier enhance accumulation at lesions with help exosomes homing ability angiopep-2 peptides. Specifically, an upregulation expression can reprogram from pro-inflammatory M1 phenotype anti-inflammatory M2 while also restoring its capacity phagocytose nerve repair function. In addition, reduces production plaques source knocking out BACE1 gene, which expected further effect AD. in vivo study suggests that TSEL through synergistic two drugs ameliorate APP/PS1 mice cognitive impairment regulating activated microglial phenotype, reducing Aβ, preventing retriggering neuroinflammation. This employs delivery dual nucleic acids, achieving AD, thus offering more options treatment
Language: Английский
Citations
30
Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 790 - 790
Published: May 7, 2024
Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]
Language: Английский
Citations
19
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Retinal diseases can severely impair vision and even lead to blindness, posing significant threats both physical mental health. Physical retinal regenerative therapies are poised revolutionize the treatment of various disorders associated with blindness. However, these must overcome challenges posed by protective inner outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential addressing issue drug delivery eye. Moreover, nanotechnology-based therapeutics profound clinical impacts on retinopathy, particularly regeneration, thereby improving patient outcomes. Continuous advancements nanotechnology being applied regenerate lost or damaged eye tissues treat loss blindness caused degenerative diseases. These approaches be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, other essential substances; ii) nanoscaffolds providing biocompatible support; iii) nanocomposites enhancing functionality primary stem cells. The aim this comprehensive review is present current understanding a focus perspective functions nanomaterials.
Language: Английский
Citations
2
JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 486 - 520
Published: Feb. 10, 2025
Tetrahedral framework nucleic acids (tFNAs) represent a promising advancement in acid nanotechnology due to their unique structural properties, high biocompatibility, and multifaceted biomedical applications. Constructed through one-pot annealing method, four single-stranded DNAs self-assemble into stable, three-dimensional tetrahedral nanostructures with enhanced mechanical robustness physiological stability, resisting enzymatic degradation. Their ability permeate mammalian cells without transfection agents, coupled modifiable surfaces, positions tFNAs as versatile carriers for drug gene delivery systems. The tFNA-based platforms exhibit superior therapeutic efficacy, including antioxidative anti-inflammatory effects, alongside efficient cellular uptake tissue penetration. These features underpin role precision medicine, enabling targeted of diverse agents such synthetic compounds, peptides, acids. Additionally, demonstrate significant potential regenerative immune modulation, antibacterial strategies, oncology. By addressing challenges translational integration, stand poised accelerate the development research clinical applications, fostering novel therapies enhancing outcomes across wide spectrum diseases. This Perspective thoroughly details attributes applications critically evaluates tFNAs' potential, outlining inherent implementation exploring solutions these obstacles.
Language: Английский
Citations
2