Biomaterials Advances, Journal Year: 2022, Volume and Issue: 139, P. 213039 - 213039
Published: July 21, 2022
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 458 - 474
Published: April 6, 2024
Language: Английский
Citations
8
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)
Published: Jan. 7, 2024
Abstract Immune checkpoint blockade (ICB) therapy has emerged as a promising approach in clinical oncology. For brain metastases, the presence of robust blood–brain barrier (BBB) and potential immune‐related adverse events (irAEs) pose significant challenges. Here, multistage‐responsive antibody‐delivery strategy is developed for non‐small cell lung cancer (NSCLC) with ultra‐pH sensitivity borate bonds. The nanoformulation (MB‐aPDL1) able to maintain “silent state” health tissue, cross BBB/BTB by GLUT1‐mediated transcytosis, release functionalized aPDL1 responsively, promote tumor‐anchoring. In vivo tumor region, MB‐aPDL1 rapidly releases activated BPA 6 ‐aPDL1, which successfully anchors cells improves efficiency ICB therapy. two studies show growth inhibition from an encouraging cure rate 20% NSCLC due enhanced immune response tumor, commendably less behavioral reactions liver damage. Taken together, this holds substantial application treatment metastases.
Language: Английский
Citations
7
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(3), P. 032001 - 032001
Published: Feb. 22, 2024
Sodium nitroprusside (SNP), U.S approved drug has been used in clinical emergency as a hypertensive for more than decade. It is well established its various biomedical applications such angiogenesis, wound healing, neurological disorders including anti-microbial etc. Apart from that, SNP have considered excellent materials use anti-cancer agent because of behavior NO-donor. Recent reports suggest that incorporation metals SNP/encapsulation metal nanoparticles (metal analogues) shows better therapeutic activity. Although there are numerous available regarding the biological and metal-based analogue nanoparticles, unfortunately not single comprehensive review which highlights activity derivative analogues detail along with future perspective. To this end, present article focuses recent development analogues, their plausible mechanism action, current status. Furthermore, perspectives challenges these also discussed. Overall, represents new perspective area cancer nanomedicine will attract wider spectrum scientific community.
Language: Английский
Citations
7
Molecular Pharmaceutics, Journal Year: 2021, Volume and Issue: 18(7), P. 2694 - 2702
Published: June 10, 2021
Brain metastases from breast cancer are the most frequent brain metastasis in women, which often difficult to be surgically removed due multifocal and infiltrative intracranial growth patterns. Cytotoxic drugs have potent anti-breast properties. However, owing toxic side effects blood–brain barrier (BBB), these cannot fully aggressively exploited with systemic administration hence very limited application for metastases. In this study, hyaluronidase-activated prodrug hyaluronic-doxorubicin (hDOX) was assembled by BBB metastatic dual-targeting nanoparticles (NPs), were constructed based on transcytosis-targeting peptide hyaluronic acid co-modified poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxy-l-lysine). hDOX showed enzyme-recovered DNA insertion, selective cytotoxicity cells rather than astrocytes, efficient loading into NPs. hDOX@NPs displayed ability of dually targeting significantly extended median survival time mice cancer. Based improvements, delivery tactic may serve as an important direction drug therapy against
Language: Английский
Citations
33
Biomaterials Advances, Journal Year: 2022, Volume and Issue: 139, P. 213039 - 213039
Published: July 21, 2022
Language: Английский
Citations
28