Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 169 - 184
Published: June 24, 2023
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 7890 - 7906
Published: March 6, 2024
Ferroptosis is a vital driver of pathophysiological consequences Alzheimer's disease (AD). High-efficiency pharmacological inhibition ferroptosis requires comprehensive coordination diverse abnormal intracellular events, which an urgent problem and great challenge for its application in AD treatment. Herein, triphenylphosphonium-modified quercetin-derived smart nanomedicine (TQCN) developed multipronged anti-ferroptosis therapy AD. Taking advantage the favorable brain-targeting mitochondria-locating properties, TQCN can efficiently chelate iron through phytopolyphenol-mediated spontaneous self-assemble into metal-phenolic nanocomplexes situ, exerting escalating exogenous offensive effects to attenuate overload induced free radical burst. Meanwhile, Nrf2 signaling-mediated endogenous defensive system reconstituted restore metabolism homeostasis represented by export storage enhance cytoprotective antioxidant cascades lipid peroxidation detoxification. Benefiting from multifaceted regulation pathogenic processes triggering ferroptosis, treatment ameliorate various neurodegenerative manifestations associated with brain deposition rescue severe cognitive decline mice. This work displays promise situ self-assembled phytopolyphenol-coordinated intelligent nanotherapeutics as advanced candidates against ferroptosis-driven progression.
Language: Английский
Citations
20
Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 317 - 317
Published: April 26, 2024
Rare earth elements (REEs) are a new type of material resource which have attracted significant attention in recent years. REEs emerged as essential metals modern-day technology due to their unique functions. The long-term, large-scale mining and utilization rare earths has caused serious environmental pollution constitutes global health issue, raised concerns regarding the safety human health. However, toxicity profile suspended particulate matter environment, interacts with body, remains largely unknown. Studies shown that can enter body through variety pathways, leading organ system dysfunctions changes genetics, epigenetics, signaling pathways. Through an extensive literature search critical analysis, we provide comprehensive overview available evidence, identify knowledge gaps, make recommendations for future research directions.
Language: Английский
Citations
20
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
10
Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101443 - 101443
Published: Jan. 5, 2025
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.
Language: Английский
Citations
4
Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138
Published: Jan. 28, 2025
Language: Английский
Citations
3
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(12), P. 4032 - 4044
Published: May 7, 2021
Insurmountable blood‒brain barrier (BBB) and complex pathological features are the key factors affecting treatment of Alzheimer's disease (AD). Poor accumulation drugs in lesion sites undesired effectiveness simply reducing Aβ deposition or TAU protein need to be resolved urgently. Herein, a nanocleaner is designed with rapamycin-loaded ROS-responsive PLGA core surface modification KLVFF peptide acid-cleavable DAG [R@(ox-PLGA)-KcD]. can enhance targeting internalization effect towards neurovascular unit endothelial cells AD lesions, subsequently detach from response acidic microenvironment endosomes promote transcytosis into brain parenchyma. Then exposed capture carry microglia, attenuating Aβ-induced neurotoxicity. Strikingly, rapamycin, an autophagy promoter, rapidly liberated high ROS level lesions improve degradation normalize inflammatory condition. This design altogether accelerates alleviates oxidative stress excessive response. Collectively, our finding offers strategy target precisely multi-pronged therapies for clearing toxic proteins modulating microenvironment, achieve efficient therapy.
Language: Английский
Citations
63
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 835 - 835
Published: April 11, 2022
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder. Most existing treatments only provide symptomatic solutions. Here, we introduce currently available commercial drugs new therapeutics, including repositioned drugs, to treat AD. Despite tremendous efforts, targeting the hallmarks of AD show limited efficacy. Challenges in treating are partly caused by difficulties penetrating blood-brain barrier (BBB). Recently, nanoparticle (NP)-based systems have shown promising potential as precision medicines that can effectively penetrate BBB enhance ability numerous drugs. describe how NPs enter brain crossing, avoiding, or disrupting BBB. In addition, overview action microenvironment for treatment Diverse systems, liposomes, micelles, polymeric NPs, solid-lipid inorganic been investigated NP drug loading relieve symptoms, target hallmarks, moieties diagnose We also highlight NP-based immunotherapy, which has recently gained special attention a option disrupt progression. Overall, this review focuses on represent innovative strategies understand pathogenesis suggests diagnostic modalities cure
Language: Английский
Citations
63
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(2), P. 517 - 541
Published: Oct. 13, 2022
Attributed to the miniaturized body size and active mobility, micro- nanomotors (MNMs) have demonstrated tremendous potential for medical applications. However, from bench bedside, massive efforts are needed address critical issues, such as cost-effective fabrication, on-demand integration of multiple functions, biocompatibility, biodegradability, controlled propulsion in vivo navigation. Herein, we summarize advances biomedical MNMs reported past two decades, with particular emphasis on design, propulsion, navigation, abilities biological barriers penetration, biosensing, diagnosis, minimally invasive surgery targeted cargo delivery. Future perspectives challenges discussed well. This review can lay foundation future direction MNMs, pushing one step forward road achieving practical theranostics using MNMs.
Language: Английский
Citations
61
Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(7), P. 1415 - 1455
Published: March 31, 2022
Abstract Limited drug delivery to the brain is one of major reasons for high failure rates central nervous system (CNS) candidates. The blood–brain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing enzymes a main player in brain, restricting entrance drugs other xenobiotics. Current knowledge about uptake transporters expressed at BBB parenchymal cells has been used CNS via targeting transporters. Although many transporter-utilizing (pro)drugs nanocarriers have developed improve their success rate translation from preclinical development humans negligible. In present review, we provide systematic summary current progress brain. addition, applied pharmacokinetic concepts evaluation limitations gaps investigation nanocarriers. Finally, give recommendations rational systems based on principles.
Language: Английский
Citations
57
Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(7), P. 897 - 897
Published: July 20, 2022
The earliest example of in vivo expression exogenous mRNA is by direct intramuscular injection mice without the aid a delivery vehicle. current state art for therapeutic nucleic acid lipid nanoparticles (LNP), which are composed cholesterol, helper lipid, PEGylated and an ionizable amine-containing lipid. liver primary organ LNP accumulation following intravenous administration also observed to varying degrees subcutaneous routes. Delivery hepatocytes has potential, but there many disease indications that would benefit from non-hepatic tissue cell population targeting, such as cancer, neurological, cardiovascular infectious diseases. This review will concentrate on efforts develop next generation tissue-targeted constructs acids.
Language: Английский
Citations
54