Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122481 - 122481
Published: Jan. 22, 2024
Language: Английский
ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1464 - 1484
Published: Jan. 10, 2023
Effective drug delivery and prevention of postoperative recurrence are significant challenges for current glioblastoma (GBM) treatment. Poor is mainly due to the presence blood–brain barrier (BBB), primarily resistance GBM cells chemotherapeutic drugs an immunosuppressive microenvironment. Herein, a biomimetic nanodrug platform based on endogenous exosomes that could efficiently target brain without targeting modifications co-deliver pure nanomicelles immune adjuvants safe efficient chemo-immunotherapy against prepared. Inspired by self-assembly technology small molecules, tanshinone IIA (TanIIA) glycyrrhizic acid (GL), which inhibitors signal transducers activators transcription 3 from traditional Chinese medicine (TCM), self-assembled form TanIIA-GL (TGM). Endogenous serum selected coat nanomicelles, CpG oligonucleotides, agonists Toll-like receptor 9, anchored exosome membrane obtain loaded with TCM (CpG-EXO/TGM). Our results demonstrate CpG-EXO/TGM can bind free transferrin in blood, prolong blood circulation, maintain intact structures when traversing BBB cells. In microenvironment, strong anti-GBM effect attributed two factors: (i) highly uptake sufficient intracellular release induce apoptosis (ii) stimulation dendritic cell maturation induction tumor-associated macrophages polarization oligonucleotides generate responses. Further research found not only produce better efficacy combination temozolomide but also prevent recurrence.
Language: Английский
Citations
122
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: July 14, 2023
Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.
Language: Английский
Citations
103
Progress in Materials Science, Journal Year: 2023, Volume and Issue: 134, P. 101070 - 101070
Published: Jan. 16, 2023
Language: Английский
Citations
86
Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(12), P. 1908 - 1922
Published: Jan. 1, 2022
This review summarizes the research progress and applications of different types self-assembled nanodrug delivery systems, which are expected to have potential therapeutic value in field biomedicine future.
Language: Английский
Citations
72
ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12176 - 12187
Published: June 30, 2023
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration and accumulation of oxidative substance, would severely impede neurological functional recovery lead to permanent profound neurologic deficits even disability. Methylprednisolone (MP) the most commonly used clinical anti-inflammatory drug for SCI treatment, but high doses are typically required that can cause severe side effects. Here, we developed a carrier-free thioketal linked MP dimer@rutin nanoparticles (MP2-TK@RU NPs) achieve combined treatment coassembling reactive oxygen species (ROS) cleavable dimers rutin. This proposed nanodrug possesses following favorable advantages: (1) system easily accessible has drug-loading capacity, preferred pharmaceutical industry; (2) The ROS-cleavable linker increases efficiency targeted delivery site; (3) Rutin, type plant-derived natural flavonoid with good biocompatibility, anti-inflammatory, antioxidant properties, codelivered enhance therapy outcomes. obtained MP2-TK@RU NPs exhibited potent antioxidative properties both in vitro vivo, demonstrating superior locomotor function neuroprotective efficacy rats SCI. anticipated provide promising therapeutic strategy treatment.
Language: Английский
Citations
47
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 18, 2024
Abstract Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune tolerance, immunosuppressive environment, tumor heterogeneity, escape, and other factors, the efficacy of immunotherapy been limited with its application very small population size. Energy metabolism not only affects progression but also plays a crucial role escape. Tumor cells are more metabolically active need energy nutrients maintain their growth, which causes surrounding lack glucose, oxygen, nutrients, result decreased cell activity increased cells. On hand, utilize multiple metabolic pathways, for instance, cellular respiration, oxidative phosphorylation pathways normal function. Studies have shown that there is difference expenditure resting activated states. Notably, competitive uptake glucose main cause impaired T Conversely, glutamine competition often activation most transformation CD4 + into inflammatory subtypes. Excessive metabolite lactate impairs function NK Furthermore, PGE2 inhibits response by inhibiting Th1 differentiation, B function, activation. Additionally, tumor-suppressive M1 macrophages cancer-promoting M2 influenced metabolism. Therefore, vital factor involved reconstruction microenvironment. Noteworthy does program affect antigen presentation recognition cells, own functions, ultimately leading changes Metabolic intervention can improve tumors, increase immunogenicity thereby expanding who benefit from immunotherapy. Consequently, identifying crosstalk molecules link microenvironment would be promising anti-tumor strategy. AMPK (AMP-activated protein kinase) ubiquitous serine/threonine kinase eukaryotes, serving central regulator pathways. The sequential associated signaling cascades profoundly impacts dynamic alterations bioenergetics. By modulating responses, exerts influence on development, while playing pivotal regulating AMPK-mediated facilitates recruitment (TIME), impeding tumorigenesis, progression, metastasis. AMPK, between homeostasis, bioenergetics, immunity, will impact treatment management oncology patients. That being summarized, objective review pinpoint provide guidance development strategies.
Language: Английский
Citations
19
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 1195 - 1218
Published: March 1, 2023
Abstract: Malignant tumor, the leading cause of death worldwide, poses a serious threat to human health. For decades, natural product has been proven be an essential source for novel anticancer drug discovery. Shikonin (SHK), molecule separated from root Lithospermum erythrorhizon , shows great potential in therapy. However, its further clinical application is significantly restricted by poor bioavailability, adverse effects, and non-selective toxicity. With development nanotechnology, nano delivery systems have emerged as promising strategies improve bioavailability enhance therapeutic efficacy drugs. To overcome shortcoming SHK, various such liposomes, polymeric micelles, nanoparticles, nanogels, nanoemulsions, were developed achieve efficient enhanced antitumor effects. Herein, this review summarizes pharmacological activities pharmacokinetics SHK. Additionally, latest progress SHK nanomedicines cancer therapy outlined, focusing on long circulation, tumor targeting ability, microenvironment responsive release, nanosystem-mediated combination Finally, challenges prospects future are spotlighted. Graphical Keywords: shikonin, therapy, pharmacokinetics, nanomedicine,
Language: Английский
Citations
37
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures and dynamics of can be affected by a variety non-covalent interactions, so it is essential to ensure the self-assembly process at atomic level. Molecular (MD) simulation key technology link microcosm macroscale. Along with rapid development computational power methods, scientists could simulate specific intermolecular interactions. Thus, some experimental observations explained microscopic level synthesis would have traces follow. This review not only outlines concept, basic principle, parameter setting MD simulation, but also highlights recent progress for self-assembled nanomedicine. In addition, physicochemical parameters structure interaction between various assembled molecules under are discussed. Therefore, this will help advanced novice researchers quickly zoom on fundamental information gather thought-provoking ideas advance subfield
Language: Английский
Citations
30
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1712 - 1712
Published: June 12, 2023
Photodynamic diagnostics (PDD) and photodynamic therapy (PDT) are well-established medical technologies used for the diagnosis treatment of malignant neoplasms. They rely on use photosensitizers, light oxygen to visualize or eliminate cancer cells. This review demonstrates recent advancements in these modalities with nanotechnology, including quantum dots as innovative photosensitizers energy donors, liposomes micelles. Additionally, this literature explores combination PDT radiotherapy, chemotherapy, immunotherapy, surgery treating various The article also focuses latest achievements PDD enhancements, which seem be very promising field oncology.
Language: Английский
Citations
28
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 22, 2023
Breast cancer (BC) is the most frequently diagnosed malignant tumor among women in world. BC heterogeneous with different subtypes including luminal A-like, B-like (HER2-/HER2+), HER2 enriched, and triple-negative BC. The therapeutic strategies surgery, chemotherapy, radiotherapy, targeted therapy, endocrine therapy are well developed commonly used treatment of However, some adverse effects these conventional treatments limited their wide application clinical. Therefore, it necessary to develop more safe efficient individualized Nanomedicine, as promising strategy for controlled drug delivery, widely multiple aspects therapy. Importantly, accumulative evidences show that nanomedicine has achieved good outcomes a huge amount patients benefited from related treatments. In this review, we summarized discussed major problems occurred during administration potential roles promoting efficacy by overcoming obstacles current
Language: Английский
Citations
27