Free Radical Biology and Medicine,
Journal Year:
2022,
Volume and Issue:
190, P. 75 - 93
Published: July 31, 2022
NRF2
(Nuclear
factor
E2
p45‐related
2)
is
a
stress
responsive
transcription
lending
cells
resilience
against
oxidative,
xenobiotic,
and
also
nutrient
or
proteotoxic
insults.
AMPK
(AMP-activated
kinase),
considered
as
prime
regulator
of
cellular
energy
homeostasis,
not
only
tunes
metabolism
to
provide
the
cell
at
any
time
with
sufficient
ATP
building
blocks,
but
controls
redox
balance
inflammation.
Due
observed
overlapping
responses
upon
activation
common
stressors
impinging
on
both
signaling,
it
plausible
assume
that
signaling
may
interdepend
cooperate
readjust
homeostasis.
After
short
introduction
two
players
this
narrative
review
paints
current
picture
how
might
interact
molecular
level,
highlights
their
possible
crosstalk
in
selected
examples
pathophysiology
bioactivity
drugs
phytochemicals.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(6), P. 2483 - 2509
Published: Feb. 15, 2023
New
drug
discovery
is
under
growing
pressure
to
satisfy
the
demand
from
a
wide
range
of
domains,
especially
pharmaceutical
industry
and
healthcare
services.
Assessment
efficacy
safety
prior
human
clinical
trials
crucial
part
development,
which
deserves
greater
emphasis
reduce
cost
time
in
discovery.
Recent
advances
microfabrication
tissue
engineering
have
given
rise
organ-on-a-chip,
an
Current Issues in Molecular Biology,
Journal Year:
2022,
Volume and Issue:
44(7), P. 3156 - 3165
Published: July 9, 2022
Mitochondria
are
generally
considered
the
powerhouse
of
cell,
a
small
subcellular
organelle
that
produces
most
cellular
energy
in
form
adenosine
triphosphate
(ATP).
In
addition,
mitochondria
involved
various
biological
functions,
such
as
biosynthesis,
lipid
metabolism,
oxidative
phosphorylation,
cell
signal
transduction,
and
apoptosis.
Mitochondrial
dysfunction
is
manifested
different
aspects,
like
increased
mitochondrial
reactive
oxygen
species
(ROS),
DNA
(mtDNA)
damage,
(ATP)
synthesis
disorder,
abnormal
mitophagy,
well
changes
morphology
structure.
related
to
occurrence
development
chronic
liver
diseases,
including
hepatocellular
carcinoma
(HCC),
viral
hepatitis,
drug-induced
injury
(DILI),
alcoholic
fatty
(AFL),
non-alcoholic
(NAFL).
this
review,
we
summarize
discuss
role
mechanisms
disease,
focusing
on
discussing
some
latest
studies
disease.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3067 - 3067
Published: Feb. 4, 2023
Acute
liver
injury
(ALI)
is
a
globally
important
public
health
issue
that,
when
severe,
rapidly
progresses
to
acute
failure,
seriously
compromising
the
life
safety
of
patients.
The
pathogenesis
ALI
defined
by
massive
cell
death
in
liver,
which
triggers
cascade
immune
responses.
Studies
have
shown
that
aberrant
activation
nod-like
receptor
protein
3
(NLRP3)
inflammasome
plays
an
role
various
types
and
NLRP3
causes
programmed
(PCD),
these
effectors
can
turn
regulate
activation.
This
indicates
inextricably
linked
PCD.
In
this
review,
we
summarize
PCD
(APAP,
ischemia
reperfusion,
CCl4,
alcohol,
Con
A,
LPS/D-GalN
induced
ALI)
analyze
underlying
mechanisms
provide
references
for
future
relevant
studies.
Biochemical Pharmacology,
Journal Year:
2024,
Volume and Issue:
228, P. 116056 - 116056
Published: Feb. 11, 2024
Liver
injury
and
acute
liver
failure
caused
by
an
acetaminophen
(APAP)
overdose
is
a
significant
clinical
problem
in
western
countries.
With
the
introduction
of
mouse
model
APAP
hepatotoxicity
1970
s,
fundamental
mechanisms
cell
death
were
discovered.
This
included
recognition
that
part
dose
metabolized
cytochrome
P450
generating
reactive
metabolite
detoxified
glutathione.
After
partial
depletion
glutathione,
will
covalently
bind
to
sulfhydryl
groups
proteins,
which
initiating
event
toxicity.
insight
led
N-acetyl-L-cysteine,
glutathione
precursor,
as
antidote
against
clinic.
Despite
substantial
progress
our
understanding
pathomechanisms
over
last
decades
viable
new
antidotes
only
emerged
recently.
review
discuss
background,
action,
prospects
existing
FDA-approved
N-acetylcysteine,
several
drug
candidates
under
development
[4-methylpyrazole
(fomepizole),
calmangafodipir]
examples
additional
therapeutic
targets
(Nrf2
activators)
regeneration
promoting
agents
(thrombopoietin
mimetics,
adenosine
A2B
receptor
agonists,
Wharton's
Jelly
mesenchymal
stem
cells).
Although
there
are
clear
limitations
certain
approaches,
reason
be
optimistic.
The
pathophysiology
consideration
drugs
for
recent
years.
Based
on
currently
available
information,
it
likely
this
result
could
used
adjunct
treatment
N-acetylcysteine.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(4), P. 1413 - 1435
Published: Jan. 1, 2024
Caspase-11
detection
of
intracellular
lipopolysaccharide
mediates
non-canonical
pyroptosis,
which
could
result
in
inflammatory
damage
and
organ
lesions
various
diseases
such
as
sepsis.Our
research
found
that
lactate
from
the
microenvironment
acetaminophen-induced
acute
liver
injury
increased
levels,
enhanced
gasdermin
D
activation
accelerated
macrophage
lead
to
exacerbation
injury.Further
experiments
unveiled
inhibits
ubiquitination
by
reducing
its
binding
NEDD4,
a
negative
regulator
Caspase-11.We
also
identified
lactates
regulated
NEDD4
K33
lactylation,
protein
interactions
between
NEDD4.Moreover,
restraining
lactylation
reduces
pyroptosis
macrophages
ameliorates
injury.Our
work
links
exquisite
regulation
inflammasome,
provides
basis
for
targeting
signaling
combat
Caspase-11-mediated
injury.
