Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3983 - 4000

Published: May 13, 2024

With the escalating prevalence of global heat waves, stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms injury, stroke-induced damage is characterized by cytotoxicity and heightened inflammation, directly contributing elevated mortality rates. While clinical assessments have identified bilirubin levels as indicative Kupffer cell dysfunction, their specific correlation with injury remains unclear. Our hypothesis proposes involvement ferroptosis during stroke, initiating IL-1

Language: Английский

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Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases

Circulation Research, Journal Year: 2024, Volume and Issue: 135(1), P. 222 - 260

Published: June 20, 2024

Cardiometabolic disease has become a major health burden worldwide, with sharply increasing prevalence but highly limited therapeutic interventions. Emerging evidence revealed that arachidonic acid derivatives and pathway factors link metabolic disorders to cardiovascular risks intimately participate in the progression severity of cardiometabolic diseases. In this review, we systemically summarized updated biological functions pathways diseases, mainly focusing on heart failure, hypertension, atherosclerosis, nonalcoholic fatty liver disease, obesity, diabetes. We further discussed cellular molecular mechanisms pathway–mediated regulation diseases highlighted emerging clinical advances improve these pathological conditions by targeting metabolites factors.

Language: Английский

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Association between aspirin use and the risk of incident nonalcoholic fatty liver disease

European Journal of Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Lipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in onset progression metabolic dysfunction-associated steatotic liver disease (MASLD). Factors augment lipophagy have identified as MASLD therapeutic development. TMEM55B key regulator positioning which critical lysosome fusion with autophagosome, but less studied. Here, we demonstrate inhibition murine models accelerates progression. In cellular models, deficiency enhances lipophagy, leading to increased fatty acid release from lysosomes mitochondria simultaneously impairs mitophagy, causing an accumulation dysfunctional mitochondria. This imbalance leads oxidative stress, worsening MASLD. These findings underscore importance metabolism suggest augmenting may exacerbate context mitochondrial dysfunction.

Language: Английский

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Gut microbiota of miR‐30a‐5p‐deleted mice aggravate high‐fat diet‐induced hepatic steatosis by regulating arachidonic acid metabolic pathway

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Language: Английский

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Polygoni Cuspidati Rhizoma et Radix extract activates TFEB and alleviates hepatic steatosis by promoting autophagy

Life Sciences, Journal Year: 2024, Volume and Issue: 359, P. 123158 - 123158

Published: Oct. 23, 2024

Language: Английский

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