Non‐Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning DOI Creative Commons

Ruiyuan Weng,

Yudian Xu,

Xinjie Gao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Moyamoya disease (MMD) is a progressive cerebrovascular disorder that increases the risk of intracranial ischemia and hemorrhage. Timely diagnosis intervention can significantly reduce new-onset stroke in patients with MMD. However, current diagnostic methods are invasive expensive, non-invasive using biomarkers MMD rarely reported. To address this issue, nanoparticle-enhanced laser desorption/ionization mass spectrometry (LDI MS) was employed to record serum metabolic fingerprints (SMFs) aim establishing method for Subsequently, model developed based on deep learning algorithms, which exhibited high accuracy differentiating group from HC (AUC = 0.958, 95% CI 0.911 1.000). Additionally, hierarchical clustering analysis revealed significant association between SMFs across different groups vascular cognitive impairment This approach holds promise as novel intuitive Furthermore, study may have broader implications other neurological disorders.

Language: Английский

Probiotics as modulators of gut-brain axis for cognitive development DOI Creative Commons
Akash Kumar, Bhagavathi Sundaram Sivamaruthi, Swarnima Dey

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Various microbial communities reside in the gastrointestinal tract of humans and play an important role immunity, digestion, drug metabolism, intestinal integrity, protection from pathogens. Recent studies have revealed that gut microbiota (GM) is involved communication with brain, through a bidirectional network known as gut-brain axis. This involves humoral, immunological, endocrine, neural pathways. Gut dysbiosis negatively impacts these pathways, leading to neurological complications cognitive deficits. Both pre-clinical clinical demonstrated probiotics can restore healthy GM, reduce pH, inflammation pathogenic microbes gut. Additionally, improve cell-to-cell signaling increase blood-brain-derived neurotrophic factors. Probiotics emerge potential approach for preventing managing Despite promising findings, safety concerns possible risks probiotic usage must be closely monitored addressed. review article provides brief overview significance health.

Language: Английский

Citations

11
The Role of the Gut Microbiota in Neurodegenerative Diseases DOI Creative Commons

Arshilin Philip Mani,

Balamuralikrishnan Balasubramanian,

Linsha A. Mali

et al.

Microbiology Research, Journal Year: 2024, Volume and Issue: 15(2), P. 489 - 507

Published: April 5, 2024

The human gut has a rich and dynamic microbial population that plays an important role in many physiological activities. This review explores the complex interaction between microbiota health, with emphasis on its effect neurodegenerative illnesses. makeup of microbiome impact brain function through gut–brain axis is highlighted. Dysbiosis, characterized by changes microbiota’s composition, been linked to development diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis. A Bidirectional communication stomach takes place via variety channels, including neurotransmitters metabolites generated bacteria. We investigate processes which dysbiosis causes neuroinflammation, oxidative stress, neuronal damage, drive disease development. Potential therapeutic approaches focus microbiota, antibiotics, probiotics, prebiotics, fecal transplantation, are reviewed, promising preclinical clinical findings. Overall, this study emphasizes relevance illnesses, well need understand target gut-brain for future treatment options.

Language: Английский

Citations

10
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease DOI Open Access
Mona Abdelhamid, Scott Counts, Chunyu Zhou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

Citations

1
The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage DOI Creative Commons
Yihui Wang,

Wen-Cao Liu,

Jianing Zhang

et al.

Brain Hemorrhages, Journal Year: 2024, Volume and Issue: 5(3), P. 117 - 130

Published: Feb. 15, 2024

Blood-brain barrier (BBB) damage is a major pathological change after intracerebral hemorrhage (ICH) and both the cause result of brain edema inflammatory response post-ICH. Cerebral immune cells (CICs), including microglia, pericytes, astrocytes play crucial role in protection BBB ICH. Recent evidence suggests that peripheral (PICs) also an important protection, edema, neurological function impairment. Therefore, regulating interactions between glial expected to alleviate ICH-induced damage. In this review, we first introduce CICs, endothelial (ECs), oligodendrocytes (OLs), PICs ICH, focusing on their polarization response. Next, specifically discuss crosstalk CICs PICs, such as brain-spleen axis brain-gut Finally, suggest cells, and, meningeal lymphatic system may be potential targets for alleviating some molecular strategies ICH by modulating ECs, PICs.

Language: Английский

Citations

5
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability DOI
Xiaoling Zhang, Weihong Du, Shuxia Qian

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(11), P. 2241 - 2252

Published: June 20, 2024

Language: Английский

Citations

5
Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis DOI Open Access
Shupeng Liu,

Yinyun Deng,

Hui Liu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2433 - 2433

Published: July 26, 2024

Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore relationship between intake aging-related phenotypes. employed Mendelian randomization (MR) select genetic variants associated with from large genomic databases, ensuring independence pleiotropy-free nature these instrumental variables (IVs), calculated F-statistic evaluate strength IVs. The validity estimates was assessed through sensitivity analyses various MR methods (MR-Egger, weighted median, inverse-variance (IVW), simple mode, mode), MR-Egger regression intercept used test for pleiotropy bias Cochran's Q heterogeneity results. findings reveal a positive consumers DNA methylation PhenoAge acceleration, suggesting increased may accelerate biological aging process. Specifically, lamb is found effect mitochondrial copy number, while processed consumption shows negative telomere length. No significant were observed other intake. highlights impact processing cooking meat's role in enhancing our understanding how their preparation affect process, providing theoretical basis dietary strategies at delaying quality life.

Language: Английский

Citations

5
Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids DOI Creative Commons
Hui Shen,

Chaoxu Zhang,

Qian Zhang

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 6, 2024

Chronic ethanol exposure (CEE) is recognized as an important risk factor for depression, and the gut-brain axis has emerged a key mechanism underlying chronic exposure-induced anxiety depression-like behaviors. Short-chain fatty acids (SCFAs), which are metabolites generated by gut microbiota from insoluble dietary fiber, exert protective roles on central nervous system, including reduction of neuroinflammation. However, link between microbial disturbances caused exposure, production SCFAs, behaviors remains unclear. Initially, 90-day model was established, followed fecal transplantation model, supplemented with SCFAs via gavage. Anxiety were determined open field test, forced swim elevated plus-maze. Serum intestinal levels quantified using GC-MS. Changes in related indicators, barrier, inflammation, neuroinflammation, neurotrophy, nerve damage, detected Western blotting, immunofluorescence, Nissl staining. disrupted homeostasis, reduced led to Recipient mice transplanted that had been affected exhibited impaired structure function, low activation compromised blood-brain neurotrophic defects, alterations GABA Notably, negative effects observed these recipient significantly alleviated through supplementation SCFAs. not only mitigate damage function but also alleviate various lesions such reduce behaviors, triggered adding more support serve bridge brain.

Language: Английский

Citations

4
Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease DOI

Simranjit Kaur,

Deepali Kumari,

Manoj P. Dandekar

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Unlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders DOI
Geetika Garg,

Anchal Trisal,

Abhishek Kumar Singh

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy DOI Open Access
Paraskevi Ioannou,

Elias Katsoulieris,

Nikolaos A. Afratis

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3621 - 3621

Published: April 11, 2025

Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix (ECM) remodeling, regulating a wide range of cellular and immune processes both homeostatic pathological conditions. Host–microbiota interactions play critical role maintaining ECM balance; however, during dysbiosis, this regulation is disrupted, leading to compromised barrier integrity, pathogen translocation into circulation, the development systemic diseases cancer. This review highlights bidirectional relationship between MMP expression/activity microbiota emphasizing tissue-specific alterations activity that contribute disease progression. In addition, it integrates interdisciplinary evidence illustrate MMP-dependent mechanisms underlying various pathologies associated with oral gut microbiome including long-range effects through gut–skin gut–brain axes. Thus, introduces emerging field MatrixBiome, which explores complex ECM, microbiota, host tissues. Finally, also outlines therapeutic strategies modulate levels, either indirectly microbiome-targeted approaches (e.g., prebiotics, probiotics, postbiotics) or directly using inhibitors, offering promising avenues for future clinical interventions.

Language: Английский

Citations

0