Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy DOI Creative Commons
Shan Lu, Ze Mi,

Jie-Ru Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness encountered limitations. In our investigation, we unveil non-dose-dependent type of behavior regarding Salmonella’s therapeutic impact and reveal the regulatory role neutrophils in diminishing efficacy this. While colonization within tumors recruits substantial neutrophil population, these predominantly polarize into pro-tumor N2 phenotype, elevating PD-L1 expression fostering an immunosuppressive milieu tumor microenvironment. order to bypass this challenge, introduce MnO2 nanoparticles engineered activate STING pathway. Harnessing pathway stimulate IFN-β secretion prompts shift polarization from N1 phenotype. This strategic repolarization remodels immune microenvironment, making infiltration activation CD8+ T cells possible. Through orchestrated mechanisms, combined employment attains synergistic enhancement anti-tumor efficacy, achieving complete inhibition growth 20 days impressive 80% survival rate 40 days, with no discernible signs significant adverse effects. Our study not only unveils crucial in vivo constraints obstructing therapy but also sets out innovative strategy augment efficacy. These findings pave way for advancements cell-based centered on leveraging potential neutrophils.

Language: Английский

Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment DOI Creative Commons

Chaoxiong Wu,

Qingyu Yu,

Chenlu Huang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

Citations

20
Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives DOI
Lijun Fu, Qing‐Yu He, Xiaoyang Lu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Abstract Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order further enhance the safety, efficacy, clinical translation potential bacterial therapy, endow bacteria with additional functions, modifications or engineering surfaces emerged as a current research hotspot. This review systematically summarizes primary methods strategies for surface modification engineering, including chemical alteration, physical modification, bio‐modification. Subsequently, it is delve into roles these techniques enhancing immunotherapy, such improving immunotherapeutic efficacy reducing toxic side effects, elucidate underlying mechanisms. Finally, challenges faced this field are deeply explored, solutions future presented. work offers comprehensive overview advancements new generation implications bacterial‐based immunotherapy.

Language: Английский

Citations

15
Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances DOI

Gaoli Niu,

Hong Wang, Yanhong Zhai

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

Citations

8
Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy DOI Creative Commons
Shan Lu, Ze Mi, Peng Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 27, 2024

Abstract Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness encountered limitations. In our investigation, we unveil non-dose-dependent type of behavior regarding ’s therapeutic impact and reveal the regulatory role neutrophils in diminishing efficacy this. While colonization within tumors recruits substantial neutrophil population, these predominantly polarize into pro-tumor N2 phenotype, elevating PD-L1 expression fostering an immunosuppressive milieu tumor microenvironment. order to bypass this challenge, introduce MnO 2 nanoparticles engineered activate STING pathway. Harnessing pathway stimulate IFN-β secretion prompts shift polarization from N1 phenotype. This strategic repolarization remodels immune microenvironment, making infiltration activation CD8 + T cells possible. Through orchestrated mechanisms, combined employment attains synergistic enhancement anti-tumor efficacy, achieving complete inhibition growth 20 days impressive 80% survival rate 40 days, with no discernible signs significant adverse effects. Our study not only unveils crucial vivo constraints obstructing therapy but also sets out innovative strategy augment efficacy. These findings pave way for advancements cell-based centered on leveraging potential neutrophils. Graphical

Language: Английский

Citations

7
Biomineralization strategy: from material manufacturing to biological regulation DOI Creative Commons

Kexin Qin,

Zitong Zheng,

Jie Wang

et al.

Giant, Journal Year: 2024, Volume and Issue: 19, P. 100317 - 100317

Published: July 4, 2024

Biomineralization plays an important role in various physiological activities both nature and living organisms. Organisms regulate the crystal nucleation, phase, growth kinetics of inorganic phases through organic regulation, forming minerals with multi-level order, thereby playing a biological support, protection, metabolic regulation. Unlike general minerals, biominerals are subtly regulated by organisms (such as small molecules, peptides, proteins, nucleic acids) complex environments, possessing characteristics becoming part It can be seen that process biomineralization is not only manufacturing biomaterials, but also using materials to themselves. The biomimetic strategy based on achieve huge transformation from preparation functional composite materials. In this review, we briefly introduce structures inspired itself, emphasize relationship between biomineralization. We explore their mechanisms. At same time, series self-cleaning hydrophobic materials, artificial spider silk fibers, mother pearl like humidity responsive bioprinting materials) synthesized strategies biomanufacturing were systematically elucidated. And brief discussion was given synthesis new organisms, such repair hard tissues, coat vaccines improve thermal stability during transportation drug delivery efficiency vivo, constructing organelles demand. Finally, article summarizes current opportunities challenges biomineralization, providing further feasible guidance for future material regulation life.

Language: Английский

Citations

6
The application of bacteria-nanomaterial hybrids in antitumor therapy DOI Creative Commons

Susu Xiao,

Min Mu,

Chenqian Feng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 4, 2024

Language: Английский

Citations

6
Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies DOI Creative Commons
Zhuangzhuang Shi, Zhaoming Li,

Mingzhi Zhang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

Citations

6
Engineered cytomembrane nanovesicles trigger in situ storm of engineered extracellular vesicles for cascade tumor penetration and immune microenvironment remodeling DOI
Fei Sun, Shipeng Ning,

Xiaoyuan Fan

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102604 - 102604

Published: Dec. 19, 2024

Language: Английский

Citations

5
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy DOI
Zhen Zhang, Xu Chen, Ningqiang Gong

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 993 - 1005

Published: Feb. 1, 2025

Language: Английский

Citations

0
Pathogen-targeting biomineralized bacterial outer membrane vesicles for eradicating both intracellular and extracellular Staphylococcus aureus DOI
Xiaohong Yang, Gongming Shi, Zihua Lin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113702 - 113702

Published: April 1, 2025

Language: Английский

Citations

0