Journal of Hepatocellular Carcinoma,
Journal Year:
2024,
Volume and Issue:
Volume 11, P. 2241 - 2256
Published: Nov. 1, 2024
Hepatocellular
carcinoma
is
the
fifth
leading
cancer
in
related
diseases
most
commonly
men
and
women.
The
curative
treatments
of
liver
are
short-listed,
associated
with
toxicities
therapeutically.
Emerging
nanotechnologies
exhibited
possibility
to
treat
or
target
cancer.
Over
years,
phytosome
solid
lipid
nanoparticles,
gold,
silver,
liposomes,
phospholipid
nanoparticles
have
been
produced
for
therapy,
some
evidence
their
effectiveness
has
established.
Ideas
limited
laboratory
scale,
order
develop
active
targeting
nanomedicine
clinical
aspects,
they
must
be
extended
a
larger
scale.
Thus,
current
review
focuses
on
previously
presently
published
research
creation
phytosomal
nanocarriers
treatment
hepatocellular
carcinoma.
In
(HCC),
nanotherapeutics
improve
targeted
delivery
bioavailability
phytochemicals
tumor
cells,
thereby
reducing
systemic
toxicity
increasing
therapeutic
efficacy.
address
intricate
molecular
processes
implicated
HCC,
this
strategy
essential.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Eliminating
cancer
stem
cells
(CSCs)
is
essential
for
the
effective
treatment
of
triple-negative
breast
(TNBC).
This
study
synthesized
Au@cerium-zinc
composite
core@shell
nanoparticles
(Au@Zn/CeO)
that
were
subsequently
conjugated
with
Escherichia
coli
(E.
coli)
to
create
engineered
bacterium
AZCE,
which
was
then
combined
microneedle
carriers
and
freeze-dried
obtain
AZCE-MN.
Upon
implantation
into
TNBC
tumors,
inherent
properties
E.
facilitate
AZCE
penetrate
extracellular
matrix
break
through
basement
membrane,
enabling
delivery
AZC
CSCs-enriched
regions
deep
within
tumor.
The
released
Zn2+
induces
mitochondrial
dysfunction
amplifies
reactive
oxygen
species
(ROS)
production.
redox
cycling
between
Ce3+/Ce4+
effectively
depleted
glutathione,
further
increased
ROS
generation.
Under
near-infrared
laser
irradiation,
Au
nanorods
initiated
photothermal
therapy,
ablating
CSCs
while
amplifying
catalytic
reactions
ionic
effects.
microneedle-mediated
bacteria
improved
nanodrug
penetration
in
tumor
tissues,
providing
new
insights
clinical
treatment.
Microbial Biotechnology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 1, 2025
Using
synthetic
biology
techniques,
bacteria
have
been
engineered
to
serve
as
microrobots
for
diagnosing
diseases
and
delivering
treatments.
These
can
be
used
individually
or
in
combination
microbial
consortia.
The
components
within
these
consortia
complement
each
other,
enhancing
diagnostic
accuracy
providing
synergistic
effects
that
improve
treatment
efficacy.
application
of
therapies
cancer,
intestinal
diseases,
metabolic
disorders
underscores
their
significant
potential.
impact
on
the
host's
native
microbiota
is
crucial,
microbes
modulate
interact
with
environment,
influencing
outcomes
overall
health.
Despite
numerous
advancements,
challenges
remain.
include
ensuring
long-term
survival
safety
bacteria,
developing
new
chassis
gene
editing
techniques
non-model
strains,
minimising
potential
toxicity,
understanding
bacterial
interactions
host
microbiota.
This
mini-review
examines
current
state
disease
diagnosis
treatment,
highlighting
challenges,
future
directions
this
promising
field.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 24, 2024
Cancer
is
measured
as
a
major
threat
to
human
life
and
leading
cause
of
death.
Millions
cancer
patients
die
every
year,
although
burgeoning
number
researchers
have
been
making
tremendous
efforts
develop
medicine
fight
against
cancer.
Owing
the
complexity
heterogeneity
cancer,
lack
ability
treat
deep
tumor
tissues,
high
toxicity
normal
cells,
it
complicates
therapy
However,
bacterial
derivative-mediated
drug
delivery
has
raised
interest
in
overcoming
restrictions
conventional
chemotherapy.
In
this
review,
we
show
various
examples
tumor-targeting
bacteria
derivatives
for
anticancer
drugs.
This
review
also
describes
advantages
limitations
delivering
treatment
drugs
under
regulated
conditions
employing
these
their
membrane
vesicles.
study
highlights
substantial
potential
clinical
translation
bacterial-based
carriers,
improve
work
with
other
modalities,
provide
more
powerful,
dependable,
distinctive
therapy.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 18, 2025
Comprehensive
Summary
Artificial
cell
wall
(ACW)
referring
to
active
functional
cellular
nano‐coatings
is
capable
of
providing
more
cell‐shell
synergic
and
cooperative
properties
than
conventional
single
nanoencapsulation
(SCNE).
With
the
development
SCNE,
issues
cytocompatibility,
degradability,
etc
.,
have
already
been
improved
successively.
However,
further
emphasis
on
cooperativity
between
itself
its
shell
still
missing
paying
attention
functions
hybrids.
Recent
research
proved
that
construction
nano‐coating
cells
not
only
needs
satisfy
functionalization
cells,
but
also
necessary
empower
interact
with
other
environments.
This
indicates
SCNEs
are
tending
be
“active”
participate
in
metabolic
process
gradually
develop
stage
ACWs.
review
provided
a
reasonable
description
artificial
wall,
realization
this
concept
requires
cooperativity,
self‐adaption
fluxionality.
Then,
methodologies
constructing
ACWs
were
discussed.
Finally,
applications
summarized
accompanied
by
potential
outlook
given
fields.
Key
Scientists
Within
recent
ten
years,
fabricating
biocompatible
surface
for
cyto‐protection
rapidly
developed.
For
example,
Rawil
F.
Fakhrullin
Yuri
M.
Lvov
developed
‘layer‐by‐layer’
strategy
construct
‘face‐lifting’
micro‐organisms.
Afterwards,
Choi
introduced
‘artificial
spore’
which
thin
tough
encapsulations.
At
same
time,
Tsukruk
hydrogel‐based
terms
2013.
In
2016,
Tang
reported
biomimetic
mineralization
can
used
improve
modify
metabolism
processes
cells.
More
advanced,
Qu
Hawker
separately
way
introduce
manganese
dioxide
nanozymes
in‐situ
‐grafting
polymers
realize
responsive
effects
towards
regulation
2017.
2018,
Huang
showed
generate
type
heritable
based
situ
self‐assembly
coacervate
micro‐droplets
around
yeast
2019,
Jeffrey
nanoparticles
adopted
exoskeletons
outside
endow
new
forming
‘supracells’.
put
forward
concepts
‘active
shell’
‘dynamic
indicated
nanoencapsulations
was
beginning
transition
control
fate
degradable
walls
2020
an
intracellular
method
regulate
algae
promote
hydrogen
production.
Based
his
previous
research,
focused
introducing
fabrication
wall’.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Preoperative
neoadjuvant
radio‐chemotherapy
is
a
cornerstone
in
the
treatment
of
low
rectal
cancer,
yet
its
effectiveness
can
be
limited
by
insensitivity
some
patients,
profoundly
impacting
their
quality
life.
Through
preliminary
research,
it
found
that
TREM2
+
macrophages
play
pivotal
role
non‐responsiveness
to
immunotherapy.
To
address
this
challenge,
novel
ionizing
radiation‐responsive
delivery
system
developed
for
precise
expression
anti‐TREM2
single‐chain
antibody
fragments
(scFv)
using
an
engineered
probiotic,
Escherichia
coli
Nissle
1917
(EcN),
modulate
The
released
scFv
precisely
targeted
and
delivered
tumor
site
via
EcN
outer
membrane
vesicles
(OMVs),
thereby
reversing
immunosuppressive
microenvironment
enhancing
therapeutic
efficiency
when
used
combination
with
αPD‐L1
immune
checkpoint
inhibitor.
Additionally,
these
bacteria
further
modified
enhance
intestinal
colonization
capabilities
through
oral
administration,
regulating
gut
microbiota
metabolic
byproducts.
Consequently,
drug
based
on
not
only
introduces
promising
new
option
cancer
but
also
showcases
potential
finely
tune
responses
within
intricate
microenvironment,
paving
way
innovative
strategies
radio‐immunotherapy.
Chimeric
antigen
receptor
(CAR)
immune
cell
therapies
have
revolutionized
oncology,
particularly
in
hematological
malignancies,
yet
their
efficacy
against
solid
tumors
remains
limited
due
to
challenges
such
as
dense
stromal
barriers
and
immunosuppressive
microenvironments.
With
advancements
nanobiotechnology,
researchers
developed
various
strategies
methods
enhance
the
CAR
tumor
treatment.
In
this
Review,
we
first
outline
structure
mechanism
of
CAR-T
(T,
T
cell),
CAR-NK
(NK,
natural
killer),
CAR-M
(M,
macrophage)
deeply
analyze
potential
these
cells
treatment
they
face.
Next,
explore
how
biomaterials
can
optimize
treatments
by
improving
microenvironment,
controlling
release,
promoting
infiltration,
enhancing
efficacy.
Finally,
summarize
current
solutions,
emphasize
effective
combination
therapy,
look
forward
its
future
clinical
application
strategies.
This
Review
provides
important
theoretical
perspectives
practical
guidance
for
development
more
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 27, 2024
Tumor
vaccines
stand
at
the
vanguard
of
tumor
immunotherapy,
demonstrating
significant
potential
and
promise
in
recent
years.
While
have
achieved
breakthroughs
treatment
cancer,
they
still
encounter
numerous
challenges,
including
improving
immunogenicity
expanding
scope
vaccine
application.
As
natural
immune
activators,
bacterial
components
offer
inherent
advantages
vaccines.
Bacterial
membrane
components,
with
their
safer
profile,
easy
extraction,
purification,
engineering,
along
diverse
array
activate
system
improve
efficacy.
This
review
systematically
summarizes
mechanism
action
therapeutic
effects
membranes
its
derivatives
(including
vesicles
hybrid
biomaterials)
Subsequently,
authors
delve
into
preparation
based
on
biomaterials.
Following
this,
outer
are
elucidated,
mechanisms
explained.
Moreover,
combination
therapy
analyzed.
Last,
challenges
trends
this
field
discussed.
comprehensive
analysis
aims
to
a
more
informed
reference
scientific
foundation
for
design
implementation
membrane-based
