Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy DOI Creative Commons
Shan Lu, Ze Mi,

Jie-Ru Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness encountered limitations. In our investigation, we unveil non-dose-dependent type of behavior regarding Salmonella’s therapeutic impact and reveal the regulatory role neutrophils in diminishing efficacy this. While colonization within tumors recruits substantial neutrophil population, these predominantly polarize into pro-tumor N2 phenotype, elevating PD-L1 expression fostering an immunosuppressive milieu tumor microenvironment. order to bypass this challenge, introduce MnO2 nanoparticles engineered activate STING pathway. Harnessing pathway stimulate IFN-β secretion prompts shift polarization from N1 phenotype. This strategic repolarization remodels immune microenvironment, making infiltration activation CD8+ T cells possible. Through orchestrated mechanisms, combined employment attains synergistic enhancement anti-tumor efficacy, achieving complete inhibition growth 20 days impressive 80% survival rate 40 days, with no discernible signs significant adverse effects. Our study not only unveils crucial in vivo constraints obstructing therapy but also sets out innovative strategy augment efficacy. These findings pave way for advancements cell-based centered on leveraging potential neutrophils.

Language: Английский

Microbial Protective Shells: A powerful tool for enhancing the bioremediation of environmental contaminants DOI
Lijuan Hao, Ziwei Zhao,

Yong Shi

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116781 - 116781

Published: April 1, 2025

Language: Английский

Citations

0
Calcium-based nanomaterials for cancer therapy DOI
Yan Huang, Bingchang Zhang, Mengqi Chen

et al.

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(24), P. 10650 - 10676

Published: June 1, 2024

Language: Английский

Citations

3
Immunotherapy revolutionizing brain metastatic cancer treatment: personalized strategies for transformative outcomes DOI Creative Commons
Ting Li,

Shichen Sun,

Yubing Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Brain metastatic cancer poses a significant clinical challenge, with limited treatment options and poor prognosis for patients. In recent years, immunotherapy has emerged as promising strategy addressing brain metastases, offering distinct advantages over conventional treatments. This review explores the evolving landscape of tumor in context cancer, focusing on intricate interplay between microenvironment (TME) immunotherapeutic approaches. By elucidating complex interactions within TME, including role immune cells, cytokines, extracellular matrix components, this highlights potential to reshape paradigm metastases. Leveraging checkpoint inhibitors, cellular immunotherapies, personalized strategies, holds promise overcoming challenges posed by blood-brain barrier immunosuppressive Through comprehensive analysis current research findings future directions, underscores transformative impact management new insights opportunities precise therapeutic interventions.

Language: Английский

Citations

3
Personalized nanovaccines for treating solid cancer metastases DOI Creative Commons
Feng Tang, Jia Hu,

Jirui Wen

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 28, 2024

Cancer vaccines have garnered attention as a potential treatment for cancer metastases. Nevertheless, the clinical response rate to remains < 30%. Nanoparticles stabilize and improve antigen recognition presentation, resulting in high tumor penetration or accumulation, effective co-distribution of drugs secondary lymphatic system, adaptable adjuvant administration. Such vaccine-like nanomedicines ability eradicate primary tumors well prevent eliminate This review examines state-of-the-art nanocarriers developed deliver metastases, including synthetic, semi-biogenic, biogenic nanosystems. Moreover, it highlights physical pharmacological properties that enhance their anti-metastasis efficiency. also addresses combination nanovaccines with immunotherapy target various steps metastatic cascade, drawing insights from preclinical studies. The concludes critical analysis challenges frameworks linked translation nanovaccines.

Language: Английский

Citations

3
Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized Metered-Dose Inhalers: A Shell Stabilization Strategy Inspired by Biomineralization DOI Open Access

Yeqi Huang,

Ziyao Chang,

Yue Gao

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3261 - 3261

Published: March 13, 2024

Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application pMDIs has hindered by low stability, i.e., tendency aggregation liposome lipid bilayer in hydrophobic propellant medium brittleness under high mechanical forces. Biomineralization is an evolutionary mechanism that organisms use resist harsh external environments nature, providing support protection effects. Inspired such a concept, this paper proposes shell stabilization strategy (SSS) solve problem stability pMDIs. Depending on material used, SSS can be classified into biomineralization (biomineralized using calcium, silicon, manganese, titanium, gadolinium, etc.) biomineralization-like (composite with protein), layer-by-layer (LbL) assembly (multiple shells structured diverse materials). This work evaluated potential reviewing studies formation deposited or similar structures. It also covered useful synthesis strategies active molecules/functional groups for modification. We aimed put forward new insights promote shed some light translation relevant products.

Language: Английский

Citations

2
Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems DOI
Peng Gao, Zhenyu Duan, Gang Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: Aug. 1, 2024

Bacterial-derived micro-/nanomedicine has garnered considerable attention in anticancer therapy, owing to the unique natural features of bacteria, including specific targeting ability, immunogenic benefits, physicochemical modifiability, and biotechnological editability. Besides, bacterial components have also been explored as promising drug delivery vehicles. Harnessing these features, cutting-edge biotechnologies applied attenuated tumor-targeting bacteria with properties or functions for potent effective cancer treatment, strategies gene-editing genetic circuits. Further, advent bacteria-inspired micro-/nanorobots mimicking artificial systems furnished fresh perspectives formulating developing highly efficient systems. Focusing on advantages this review delves into advances bacteria-derived treatment recent years, which experienced a process from living entities Meanwhile, summary relative clinical trials is provided primary challenges impeding their application are discussed. Furthermore, future directions suggested combat cancer.

Language: Английский

Citations

2
Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy DOI Creative Commons
Shan Lu, Ze Mi,

Jie-Ru Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness encountered limitations. In our investigation, we unveil non-dose-dependent type of behavior regarding Salmonella’s therapeutic impact and reveal the regulatory role neutrophils in diminishing efficacy this. While colonization within tumors recruits substantial neutrophil population, these predominantly polarize into pro-tumor N2 phenotype, elevating PD-L1 expression fostering an immunosuppressive milieu tumor microenvironment. order to bypass this challenge, introduce MnO2 nanoparticles engineered activate STING pathway. Harnessing pathway stimulate IFN-β secretion prompts shift polarization from N1 phenotype. This strategic repolarization remodels immune microenvironment, making infiltration activation CD8+ T cells possible. Through orchestrated mechanisms, combined employment attains synergistic enhancement anti-tumor efficacy, achieving complete inhibition growth 20 days impressive 80% survival rate 40 days, with no discernible signs significant adverse effects. Our study not only unveils crucial in vivo constraints obstructing therapy but also sets out innovative strategy augment efficacy. These findings pave way for advancements cell-based centered on leveraging potential neutrophils.

Language: Английский

Citations

0