Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114176 - 114176
Published: Aug. 30, 2024
Language: Английский
National Science Review, Journal Year: 2024, Volume and Issue: 11(8)
Published: June 26, 2024
ABSTRACT Periodontitis involves hyperactivated stromal cells that recruit immune cells, exacerbating inflammation. This study presents an ATP-responsive metal–organic framework (Mg/Zn-MOF) designed for periodontitis treatment, utilizing ion interference to modulate responses and prevent tissue destruction. Addressing the challenges of synergistic effects targeted delivery faced by traditional immunomodulatory nanomaterials, Mg/Zn-MOF system is activated extracellular ATP—a pivotal molecule in pathology—ensuring release. Magnesium zinc ions released from synergistically inhibit membrane pore formation attenuating Gasdermin D (GSDMD) expression activation. action curtails pyroptosis, lactate dehydrogenase IL-1β release, thwarting onset inflammatory cascades. Mechanistically, intervenes both NLRP3/Caspase-1/GSDMD Caspase-11/GSDMD pathways mitigate pyroptosis. In vivo assessments confirm its effectiveness diminishing cell infiltration preserving collagen integrity, thereby safeguarding against periodontal damage bone loss. investigation highlights promise ion-interference strategies immunotherapy, representing a significant stride developing therapeutic approaches.
Language: Английский
Citations
10
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)
Published: July 23, 2024
The bis-(diethyldithiocarbamate)-copper (CuET), the disulfiram (DSF)-Cu complex, has exhibited noteworthy anti-tumor property. However, its efficacy is compromised due to inadequate oxidative conditions and limitation of bioavailable copper. Because CuET can inactivate valosin-containing protein (VCP), a bioinformatic pan-cancer analysis VCP first conducted in this study identify as promising anticancer drug for diverse cancer types. Then, based on action mechanism, nanocomposite copper oxide (CuO) designed fabricated utilizing bovine serum albumin (BSA) template (denoted CuET-CuO@BSA, CCB). CCB manifests peroxidase (POD)-mimicking activity oxidize tumor endogenous H
Language: Английский
Citations
5
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Pyroptosis, a specialized cell death mechanism crucial in cancer therapy, is distinct from apoptosis and primary necrosis. It linked to inflammation reactive oxygen species, particularly peroxynitrite (ONOO-), which implicated disease. Monitoring pyroptosis challenging due its connection with cellular polarity the tumor environment. In this research, we developed near-infrared probe, PBQI, highly sensitive responsive ONOO- fluctuations. PBQI targets mitochondria lipid droplets, enabling real-time tracking of pyroptosis-associated subcellular alterations. was found differentiate between normal cells during triggered by cisplatin metformin. To mitigate pyroptosis-induced inflammation, disulfiram used as an inhibitor, significantly alleviating excessive inflammation. This study highlights PBQI's utility studying interplay polarity, ONOO-, pyroptosis, contributes development more targeted therapies that optimize pyroptosis's antitumor benefits while minimizing inflammatory side effects.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Abstract Macrophage‐mediated inflammatory responses including pyroptosis are involved in the pathogenesis of sepsis and acute lung injury (ALI), for which there currently no effective therapeutic treatments. The natural product (+)‐Balasubramide is an eight‐membered lactam compound extracted from leaves Sri Lanka plant Clausena Indica has shown anti‐inflammatory activities, but its poor pharmacokinetic properties limit further application ALI. In this study, a (+)3C‐20 discovered with improved both activity series derivatives. exhibits markedly enhanced inhibitory effect against LPS‐induced expressions pro‐inflammatory factors mouse macrophages human PBMCs ALI patients shows preferable tissue distribution mice. remarkably attenuates through tissue‐specific actions. Mechanistically, chemical proteomics study that directly binds to mitochondrial VDAC1 inhibits oligomerization block mtDNA release, preventing NLRP3 inflammasome activation. These findings identify as novel inhibitor promising potential associated inflammation.
Language: Английский
Citations
2
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114176 - 114176
Published: Aug. 30, 2024
Language: Английский
Citations
1