Recent advances in the bench-to-bedside translation of cancer nanomedicines DOI Creative Commons
Yang Liu, Yinchao Zhang, Huikai Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(1), P. 97 - 122

Published: Dec. 14, 2024

Cancer remains a complex and challenging medical problem, driving extensive research efforts. Despite significant progress in understanding its genetic molecular aspects, the quest for effective treatments continues. Nanomedicines have shown great potential revolutionizing cancer treatment by offering targeted controlled drug delivery, reducing side effects, improving patient outcomes. Accordingly, nanomedicines been focus of development clinical translation. As September 2024, search on ClinicalTrials.gov website using term "nanoparticles" revealed numerous ongoing planned trials. Motivated recent advances field, this review explores current frontier nanomedicine. supported chemotherapy, phototherapy sonodynamic therapy, nucleic acid immunotherapy. However, translating into practice has challenged interactions between nanoparticles biological systems, variable permeability retention tumors, safety concerns, difficulty achieving issues with scaling up manufacturing. Perspectives addressing these challenges are offered. Future opportunities nanomedicines, including modifying tumor microenvironment, integrating artificial intelligence big data, targeting new areas, also discussed. This underscores to revolutionize from standpoint.

Language: Английский

A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks DOI
Ali Khorasani, Seyed Morteza Naghib

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

Citations

2
Immunoregulatory role of exosomal circRNAs in the tumor microenvironment DOI Creative Commons
Changsheng Lv,

Jinhao Chen,

Yuxiang Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 17, 2025

As cancer incidence and mortality rates rise, there is an urgent need to develop effective immunotherapy strategies. Circular RNA (circRNA), a newly identified type of non-coding RNA, abundant within cells can be released via exosomes, facilitating communication between cells. Studies have demonstrated that exosomal circRNAs alter the tumor microenvironment modulate immune responses by influencing functions T cells, natural killer (NK) macrophages, thereby enabling tumors evade system. Moreover, show potential as diagnostic biomarkers therapeutic targets for cancer. This review summarizes regulatory roles in their applications progression treatment, highlighting promise improving immunotherapy. Future research should concentrate on understanding mechanisms key developing targeted methods.

Language: Английский

Citations

1
Circular RNAs modulate cancer drug resistance: advances and challenges DOI Open Access

Jinghan Hua,

Zhe Wang, Xiangfei Cheng

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Acquired drug resistance is a main factor contributing to cancer therapy failure and high mortality, highlighting the necessity develop novel intervention targets. Circular RNAs (circRNAs), an abundant class of RNA molecules with closed loop structure, possess characteristics including stability, which provide unique advantages in clinical application. Growing evidence indicates that aberrantly expressed circRNAs are associated against various treatments, targeted therapy, chemotherapy, radiotherapy, immunotherapy. Therefore, targeting these aberrant may offer strategy improve efficiency therapy. Herein, we present summary most recently studied their regulatory roles on resistance. With advances artificial intelligence (AI)-based bioinformatics algorithms, could emerge as promising biomarkers targets

Language: Английский

Citations

0
Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles DOI Creative Commons
Lai Li, Yun Su, Cong Hu

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

ABSTRACT Extracellular vesicles (EVs) are essential for host–pathogen interactions, mediating processes such as immune modulation and pathogen survival. Pathogen‐derived EVs hold significant diagnostic potential because of their unique cargo, offering a wealth biomarkers. In this review, we first discuss the roles derived from various pathogens in interactions summarize latest advancements detection based on EVs. Then, highlight innovative strategies, including novel aggregate materials machine learning approaches, enhancing EV analysis. Finally, challenges field future directions advancing EV‐based diagnostics, aiming to translate these insights into clinical applications.

Language: Английский

Citations

0
Healing beyond tradition: Advanced regenerative therapies for joint-related sports injuries DOI

Mingze Du,

Yue Gu, Tianhao Xu

et al.

The Innovation Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100132 - 100132

Published: Jan. 1, 2025

<p>Sports injuries are one of the most common diseases, and repair regeneration joint soft tissues (ligaments, tendons, cartilage, etc.) involved in them challenging. Traditional treatment strategies, such as drugs, physical therapy, surgery, difficult to achieve tissue reconstruction natural physiological functions. Regenerative medicine offers promising solutions, including biotherapy, engineering, prosthesis or organ transplantation. These approaches aim regenerate damaged tissues, reduce recovery time, improve functional outcomes. Stem cells from different sources their constructed organoids, novel biomaterials, 3D printing other innovative technologies have been used. Individual variability, uncertain long-term efficacy, high costs remain obstacles for clinical application. Further research is needed explore molecular mechanisms underlying regenerative therapies orchestrate biological, chemical factors.</p>

Language: Английский

Citations

0
Recent advances in the bench-to-bedside translation of cancer nanomedicines DOI Creative Commons
Yang Liu, Yinchao Zhang, Huikai Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(1), P. 97 - 122

Published: Dec. 14, 2024

Cancer remains a complex and challenging medical problem, driving extensive research efforts. Despite significant progress in understanding its genetic molecular aspects, the quest for effective treatments continues. Nanomedicines have shown great potential revolutionizing cancer treatment by offering targeted controlled drug delivery, reducing side effects, improving patient outcomes. Accordingly, nanomedicines been focus of development clinical translation. As September 2024, search on ClinicalTrials.gov website using term "nanoparticles" revealed numerous ongoing planned trials. Motivated recent advances field, this review explores current frontier nanomedicine. supported chemotherapy, phototherapy sonodynamic therapy, nucleic acid immunotherapy. However, translating into practice has challenged interactions between nanoparticles biological systems, variable permeability retention tumors, safety concerns, difficulty achieving issues with scaling up manufacturing. Perspectives addressing these challenges are offered. Future opportunities nanomedicines, including modifying tumor microenvironment, integrating artificial intelligence big data, targeting new areas, also discussed. This underscores to revolutionize from standpoint.

Language: Английский

Citations

1